Control of cardiac alternans by mechanical and electrical feedback
A persistent alternation in the cardiac action potential duration has been linked to the onset of ventricular arrhythmia, which may lead to sudden cardiac death. A coupling between these cardiac alternans and the intracellular calcium dynamics has also been identified in previous studies. In this pa...
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2014
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| Online Access: | http://hdl.handle.net/11073/16637 |
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| _version_ | 1864513437176954880 |
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| author | Yapari, Felicia |
| author2 | Deshpande, Dipen Belhamadia, Youssef Dubljevic, Stevan |
| author2_role | author author author |
| author_facet | Yapari, Felicia Deshpande, Dipen Belhamadia, Youssef Dubljevic, Stevan |
| author_role | author |
| dc.creator.none.fl_str_mv | Yapari, Felicia Deshpande, Dipen Belhamadia, Youssef Dubljevic, Stevan |
| dc.date.none.fl_str_mv | 2014 2020-02-27T07:25:14Z 2020-02-27T07:25:14Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | 2470-0053 http://hdl.handle.net/11073/16637 10.1103/PhysRevE.90.012706 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | American Physical Society |
| dc.relation.none.fl_str_mv | https://doi.org/10.1103/PhysRevE.90.012706 |
| dc.title.none.fl_str_mv | Control of cardiac alternans by mechanical and electrical feedback |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | A persistent alternation in the cardiac action potential duration has been linked to the onset of ventricular arrhythmia, which may lead to sudden cardiac death. A coupling between these cardiac alternans and the intracellular calcium dynamics has also been identified in previous studies. In this paper, the system of PDEs describing the small amplitude of alternans and the alternation of peak intracellular Ca2+ are stabilized by optimal boundary and spatially distributed actuation. A simulation study demonstrating the successful annihilation of both alternans on a one-dimensional cable of cardiac cells by utilizing the full-state feedback controller is presented. Complimentary to these studies, a three variable Nash-Panfilov model is used to investigate alternans annihilation via mechanical (or stretch) perturbations. The coupled model includes the active stress which defines the mechanical properties of the tissue and is utilized in the feedback algorithm as an independent input from the pacing based controller realization in alternans annihilation. Simulation studies of both control methods demonstrate that the proposed methods can successfully annihilate alternans in cables that are significantly longer than 1 cm, thus overcoming the limitations of earlier control efforts. |
| format | article |
| id | aus_27141aa1adbb24939d896bd67c257303 |
| identifier_str_mv | 2470-0053 10.1103/PhysRevE.90.012706 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/16637 |
| publishDate | 2014 |
| publisher.none.fl_str_mv | American Physical Society |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
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| spelling | Control of cardiac alternans by mechanical and electrical feedbackYapari, FeliciaDeshpande, DipenBelhamadia, YoussefDubljevic, StevanA persistent alternation in the cardiac action potential duration has been linked to the onset of ventricular arrhythmia, which may lead to sudden cardiac death. A coupling between these cardiac alternans and the intracellular calcium dynamics has also been identified in previous studies. In this paper, the system of PDEs describing the small amplitude of alternans and the alternation of peak intracellular Ca2+ are stabilized by optimal boundary and spatially distributed actuation. A simulation study demonstrating the successful annihilation of both alternans on a one-dimensional cable of cardiac cells by utilizing the full-state feedback controller is presented. Complimentary to these studies, a three variable Nash-Panfilov model is used to investigate alternans annihilation via mechanical (or stretch) perturbations. The coupled model includes the active stress which defines the mechanical properties of the tissue and is utilized in the feedback algorithm as an independent input from the pacing based controller realization in alternans annihilation. Simulation studies of both control methods demonstrate that the proposed methods can successfully annihilate alternans in cables that are significantly longer than 1 cm, thus overcoming the limitations of earlier control efforts.American Physical Society2020-02-27T07:25:14Z2020-02-27T07:25:14Z2014Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdf2470-0053http://hdl.handle.net/11073/1663710.1103/PhysRevE.90.012706en_UShttps://doi.org/10.1103/PhysRevE.90.012706oai:repository.aus.edu:11073/166372024-08-22T12:01:38Z |
| spellingShingle | Control of cardiac alternans by mechanical and electrical feedback Yapari, Felicia |
| status_str | publishedVersion |
| title | Control of cardiac alternans by mechanical and electrical feedback |
| title_full | Control of cardiac alternans by mechanical and electrical feedback |
| title_fullStr | Control of cardiac alternans by mechanical and electrical feedback |
| title_full_unstemmed | Control of cardiac alternans by mechanical and electrical feedback |
| title_short | Control of cardiac alternans by mechanical and electrical feedback |
| title_sort | Control of cardiac alternans by mechanical and electrical feedback |
| url | http://hdl.handle.net/11073/16637 |