Recent advances on the anti-cancer properties of Nigella sativa, a widely used food additive
The use of naturally-occurring agents to regulate tumorigenesis is on the rise. Several herbal extracts, pure plant-derived active constituents, and food additives have been reported to possess potent anti-cancer properties and cancer-ameliorating effects. The wide-range anti-cancer effects of Nigel...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | |
| التنسيق: | article |
| منشور في: |
2016
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/11073/25049 |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513436700901376 |
|---|---|
| author | Majdalawieh, Amin |
| author2 | Fayyad, Muneera W. |
| author2_role | author |
| author_facet | Majdalawieh, Amin Fayyad, Muneera W. |
| author_role | author |
| dc.creator.none.fl_str_mv | Majdalawieh, Amin Fayyad, Muneera W. |
| dc.date.none.fl_str_mv | 2016 2022-10-25T07:35:00Z 2022-10-25T07:35:00Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Amin F. Majdalawieh, Muneera W. Fayyad, Recent advances on the anti-cancer properties of Nigella sativa, a widely used food additive, Journal of Ayurveda and Integrative Medicine, Volume 7, Issue 3, 2016, Pages 173-180, ISSN 0975-9476, https://doi.org/10.1016/j.jaim.2016.07.004. 0976-2809 http://hdl.handle.net/11073/25049 10.1016/j.jaim.2016.07.004 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.relation.none.fl_str_mv | https://doi.org/10.1016/j.jaim.2016.07.004 |
| dc.subject.none.fl_str_mv | Nigella sativa Anti-cancer Apoptosis Cytotoxicity NK cytotoxic activity |
| dc.title.none.fl_str_mv | Recent advances on the anti-cancer properties of Nigella sativa, a widely used food additive |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | The use of naturally-occurring agents to regulate tumorigenesis is on the rise. Several herbal extracts, pure plant-derived active constituents, and food additives have been reported to possess potent anti-cancer properties and cancer-ameliorating effects. The wide-range anti-cancer effects of Nigella sativa, also known as black seed or black cumin, have been extensively studied using different in vitro and in vivo models. Here, we provide a comprehensive, analytical review of the reported anti-cancer properties of N. sativa seed extracts. This review focuses on analyzing experimental findings related to the ability of N. sativa to exert anti-proliferative, pro-apoptotic, anti-oxidant, cytotoxic, anti-mutagenic, anti-metastatic, and NK cytotoxic activity enhancing effects against various primary cancer cells and cancer cell lines. Moreover, we underline the molecular mechanisms of action and the signal transduction pathways implicated in the suppression of tumorigenesis by N. sativa. The major signaling pathway utilized by N. sativa to manifest its anti-cancer activity is the iNOS signaling pathway. This review underscores the recent developments that highlight an effective therapeutic potential of N. sativa to suppress tumor development, reduce tumor incidence, and ameliorate carcinogenesis. In sum, experimental findings reported in the last two decades strongly suggest that N. sativa fractions could serve, alone or in combination with known chemotherapeutic drugs, as effective agents to control tumor initiation, growth, and metastasis, and hence, treatment of a wide range of cancers. |
| format | article |
| id | aus_2ae1c673d9d898d41a0a24075652012d |
| identifier_str_mv | Amin F. Majdalawieh, Muneera W. Fayyad, Recent advances on the anti-cancer properties of Nigella sativa, a widely used food additive, Journal of Ayurveda and Integrative Medicine, Volume 7, Issue 3, 2016, Pages 173-180, ISSN 0975-9476, https://doi.org/10.1016/j.jaim.2016.07.004. 0976-2809 10.1016/j.jaim.2016.07.004 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/25049 |
| publishDate | 2016 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Recent advances on the anti-cancer properties of Nigella sativa, a widely used food additiveMajdalawieh, AminFayyad, Muneera W.Nigella sativaAnti-cancerApoptosisCytotoxicityNK cytotoxic activityThe use of naturally-occurring agents to regulate tumorigenesis is on the rise. Several herbal extracts, pure plant-derived active constituents, and food additives have been reported to possess potent anti-cancer properties and cancer-ameliorating effects. The wide-range anti-cancer effects of Nigella sativa, also known as black seed or black cumin, have been extensively studied using different in vitro and in vivo models. Here, we provide a comprehensive, analytical review of the reported anti-cancer properties of N. sativa seed extracts. This review focuses on analyzing experimental findings related to the ability of N. sativa to exert anti-proliferative, pro-apoptotic, anti-oxidant, cytotoxic, anti-mutagenic, anti-metastatic, and NK cytotoxic activity enhancing effects against various primary cancer cells and cancer cell lines. Moreover, we underline the molecular mechanisms of action and the signal transduction pathways implicated in the suppression of tumorigenesis by N. sativa. The major signaling pathway utilized by N. sativa to manifest its anti-cancer activity is the iNOS signaling pathway. This review underscores the recent developments that highlight an effective therapeutic potential of N. sativa to suppress tumor development, reduce tumor incidence, and ameliorate carcinogenesis. In sum, experimental findings reported in the last two decades strongly suggest that N. sativa fractions could serve, alone or in combination with known chemotherapeutic drugs, as effective agents to control tumor initiation, growth, and metastasis, and hence, treatment of a wide range of cancers.Elsevier2022-10-25T07:35:00Z2022-10-25T07:35:00Z2016Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfAmin F. Majdalawieh, Muneera W. Fayyad, Recent advances on the anti-cancer properties of Nigella sativa, a widely used food additive, Journal of Ayurveda and Integrative Medicine, Volume 7, Issue 3, 2016, Pages 173-180, ISSN 0975-9476, https://doi.org/10.1016/j.jaim.2016.07.004.0976-2809http://hdl.handle.net/11073/2504910.1016/j.jaim.2016.07.004en_UShttps://doi.org/10.1016/j.jaim.2016.07.004oai:repository.aus.edu:11073/250492024-08-22T12:00:26Z |
| spellingShingle | Recent advances on the anti-cancer properties of Nigella sativa, a widely used food additive Majdalawieh, Amin Nigella sativa Anti-cancer Apoptosis Cytotoxicity NK cytotoxic activity |
| status_str | publishedVersion |
| title | Recent advances on the anti-cancer properties of Nigella sativa, a widely used food additive |
| title_full | Recent advances on the anti-cancer properties of Nigella sativa, a widely used food additive |
| title_fullStr | Recent advances on the anti-cancer properties of Nigella sativa, a widely used food additive |
| title_full_unstemmed | Recent advances on the anti-cancer properties of Nigella sativa, a widely used food additive |
| title_short | Recent advances on the anti-cancer properties of Nigella sativa, a widely used food additive |
| title_sort | Recent advances on the anti-cancer properties of Nigella sativa, a widely used food additive |
| topic | Nigella sativa Anti-cancer Apoptosis Cytotoxicity NK cytotoxic activity |
| url | http://hdl.handle.net/11073/25049 |