Threshold Functions for Modeling Gene Regulatory Networks
A Master of Science thesis in Mathematics by Hadeel Ali Kittaneh entitled, “Threshold Functions for Modeling Gene Regulatory Networks”, submitted in June 2024. Thesis advisor is Dr. Abdul Salam Jarrah. Soft copy is available (Thesis, Completion Certificate, Approval Signatures, and AUS Archives Cons...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| التنسيق: | doctoralThesis |
| منشور في: |
2024
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://hdl.handle.net/11073/25627 |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513443746283520 |
|---|---|
| author | Kittaneh, Hadeel Ali |
| author_facet | Kittaneh, Hadeel Ali |
| author_role | author |
| dc.contributor.none.fl_str_mv | Jarrah, Abdul Salam |
| dc.creator.none.fl_str_mv | Kittaneh, Hadeel Ali |
| dc.date.none.fl_str_mv | 2024-09-25T09:15:48Z 2024-09-25T09:15:48Z 2024-06 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | 29.232-2024.04 https://hdl.handle.net/11073/25627 |
| dc.language.none.fl_str_mv | en_US |
| dc.subject.none.fl_str_mv | Threshold Function Threshold Boolean Network Boolean Network Gene Regulatory Network Attractors Fixed point Limit cycle |
| dc.title.none.fl_str_mv | Threshold Functions for Modeling Gene Regulatory Networks |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/doctoralThesis |
| description | A Master of Science thesis in Mathematics by Hadeel Ali Kittaneh entitled, “Threshold Functions for Modeling Gene Regulatory Networks”, submitted in June 2024. Thesis advisor is Dr. Abdul Salam Jarrah. Soft copy is available (Thesis, Completion Certificate, Approval Signatures, and AUS Archives Consent Form). |
| format | doctoralThesis |
| id | aus_2d50ad5fd567374c0d9b8490aa53339b |
| identifier_str_mv | 29.232-2024.04 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/25627 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Threshold Functions for Modeling Gene Regulatory NetworksKittaneh, Hadeel AliThreshold FunctionThreshold Boolean NetworkBoolean NetworkGene Regulatory NetworkAttractorsFixed pointLimit cycleA Master of Science thesis in Mathematics by Hadeel Ali Kittaneh entitled, “Threshold Functions for Modeling Gene Regulatory Networks”, submitted in June 2024. Thesis advisor is Dr. Abdul Salam Jarrah. Soft copy is available (Thesis, Completion Certificate, Approval Signatures, and AUS Archives Consent Form).In this thesis, we explore the properties of threshold functions with a unique updating rule and their relevance to gene regulatory models. We conduct a comparative analysis between Threshold Boolean Networks (TBNs) and Random Boolean Networks, focusing on variations in the number of inputs per gene. This analysis helps us understand how input connectivity influences network stability and phase transitions. We also investigate the dynamics and robustness of TBNs, emphasizing fixed interaction rules characteristic of genetic systems, unlike previous studies that use annealed approximations. Furthermore, we propose a new approach to assess the robustness of these networks, addressing the issue of multiple attractors in threshold Boolean networks. Our findings enhance the understanding of threshold Boolean functions and their applications in modeling gene regulatory networks.College of Arts and SciencesDepartment of Mathematics and StatisticsMaster of Science in Mathematics (MSMTH)Jarrah, Abdul Salam2024-09-25T09:15:48Z2024-09-25T09:15:48Z2024-06info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisapplication/pdf29.232-2024.04https://hdl.handle.net/11073/25627en_USoai:repository.aus.edu:11073/256272025-11-11T07:05:36Z |
| spellingShingle | Threshold Functions for Modeling Gene Regulatory Networks Kittaneh, Hadeel Ali Threshold Function Threshold Boolean Network Boolean Network Gene Regulatory Network Attractors Fixed point Limit cycle |
| status_str | publishedVersion |
| title | Threshold Functions for Modeling Gene Regulatory Networks |
| title_full | Threshold Functions for Modeling Gene Regulatory Networks |
| title_fullStr | Threshold Functions for Modeling Gene Regulatory Networks |
| title_full_unstemmed | Threshold Functions for Modeling Gene Regulatory Networks |
| title_short | Threshold Functions for Modeling Gene Regulatory Networks |
| title_sort | Threshold Functions for Modeling Gene Regulatory Networks |
| topic | Threshold Function Threshold Boolean Network Boolean Network Gene Regulatory Network Attractors Fixed point Limit cycle |
| url | https://hdl.handle.net/11073/25627 |