Tumor vasculature vs tumor cell targeting: Understanding the latest trends in using functional nanoparticles for cancer treatment
Delivering drugs to tumors using nanoparticles (NPs) has shown promising potential in promoting targeted drug delivery of antineoplastic agents to enhance their efficiency while reducing the associated systemic toxicity. This review highlights the different types of NPs and the physiological charact...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , |
| التنسيق: | article |
| منشور في: |
2023
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/11073/25146 |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513435867283456 |
|---|---|
| author | Awad, Nahid S. |
| author2 | Salkho, Najla Abuwatfa, Waad Hussein Paul, Vinod AlSawaftah, Nour Majdi Husseini, Ghaleb |
| author2_role | author author author author author |
| author_facet | Awad, Nahid S. Salkho, Najla Abuwatfa, Waad Hussein Paul, Vinod AlSawaftah, Nour Majdi Husseini, Ghaleb |
| author_role | author |
| dc.creator.none.fl_str_mv | Awad, Nahid S. Salkho, Najla Abuwatfa, Waad Hussein Paul, Vinod AlSawaftah, Nour Majdi Husseini, Ghaleb |
| dc.date.none.fl_str_mv | 2023-02-27T06:35:39Z 2023-02-27T06:35:39Z 2023 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Awad, N.; Salkho, N.; Abuwatfa, W.; Paul, V.; AlSawaftah, N.; Husseini, G. Tumor vasculature VS tumor cell targeting: Understanding the latest trends in using functional nanoparticles for cancer treatment. OpenNano, 2023, 100136, ISSN 2352-9520, https://doi.org/10.1016/j.onano.2023.100136 2352-9520 http://hdl.handle.net/11073/25146 10.1016/j.onano.2023.100136 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.relation.none.fl_str_mv | https://doi.org/10.1016/j.onano.2023.100136 |
| dc.subject.none.fl_str_mv | Tumor vasculature Cell targeting Tumor Nanoparticles Cancer treatment |
| dc.title.none.fl_str_mv | Tumor vasculature vs tumor cell targeting: Understanding the latest trends in using functional nanoparticles for cancer treatment |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Delivering drugs to tumors using nanoparticles (NPs) has shown promising potential in promoting targeted drug delivery of antineoplastic agents to enhance their efficiency while reducing the associated systemic toxicity. This review highlights the different types of NPs and the physiological characteristics of the tumor microenvironment (TME), and the mechanisms undertaken to safely deliver drugs to specific lesions. We review the principles and latest developments in the field of targeted NPs designed to target tumor vasculature compared to those designed to target cancer cells and their correlation with the TME. We discuss the advantages and limitations of each targeted drug delivery mechanism and future directions aiming to maximize their potential. |
| format | article |
| id | aus_2fd6f6fddff3760ac2d51a393e232cd0 |
| identifier_str_mv | Awad, N.; Salkho, N.; Abuwatfa, W.; Paul, V.; AlSawaftah, N.; Husseini, G. Tumor vasculature VS tumor cell targeting: Understanding the latest trends in using functional nanoparticles for cancer treatment. OpenNano, 2023, 100136, ISSN 2352-9520, https://doi.org/10.1016/j.onano.2023.100136 2352-9520 10.1016/j.onano.2023.100136 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/25146 |
| publishDate | 2023 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Tumor vasculature vs tumor cell targeting: Understanding the latest trends in using functional nanoparticles for cancer treatmentAwad, Nahid S.Salkho, NajlaAbuwatfa, Waad HusseinPaul, VinodAlSawaftah, Nour MajdiHusseini, GhalebTumor vasculatureCell targetingTumor NanoparticlesCancer treatmentDelivering drugs to tumors using nanoparticles (NPs) has shown promising potential in promoting targeted drug delivery of antineoplastic agents to enhance their efficiency while reducing the associated systemic toxicity. This review highlights the different types of NPs and the physiological characteristics of the tumor microenvironment (TME), and the mechanisms undertaken to safely deliver drugs to specific lesions. We review the principles and latest developments in the field of targeted NPs designed to target tumor vasculature compared to those designed to target cancer cells and their correlation with the TME. We discuss the advantages and limitations of each targeted drug delivery mechanism and future directions aiming to maximize their potential.American University of SharjahAlJalila FoundationAl Qasimi FoundationPatient’s Friends Committee of SharjahBiosciences and Bioengineering Research InstituteGCC Co-Fund ProgramTakamul programTechnology Innovation Pioneer (TIP) Healthcare AwardsSheikh Hamdan Award for Medical SciencesDana Gas Endowed Chair for Chemical EngineeringMaterial Science and Engineering Ph.D. program at AUSElsevier2023-02-27T06:35:39Z2023-02-27T06:35:39Z2023Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfAwad, N.; Salkho, N.; Abuwatfa, W.; Paul, V.; AlSawaftah, N.; Husseini, G. Tumor vasculature VS tumor cell targeting: Understanding the latest trends in using functional nanoparticles for cancer treatment. OpenNano, 2023, 100136, ISSN 2352-9520, https://doi.org/10.1016/j.onano.2023.1001362352-9520http://hdl.handle.net/11073/2514610.1016/j.onano.2023.100136en_UShttps://doi.org/10.1016/j.onano.2023.100136oai:repository.aus.edu:11073/251462024-08-22T12:04:36Z |
| spellingShingle | Tumor vasculature vs tumor cell targeting: Understanding the latest trends in using functional nanoparticles for cancer treatment Awad, Nahid S. Tumor vasculature Cell targeting Tumor Nanoparticles Cancer treatment |
| status_str | publishedVersion |
| title | Tumor vasculature vs tumor cell targeting: Understanding the latest trends in using functional nanoparticles for cancer treatment |
| title_full | Tumor vasculature vs tumor cell targeting: Understanding the latest trends in using functional nanoparticles for cancer treatment |
| title_fullStr | Tumor vasculature vs tumor cell targeting: Understanding the latest trends in using functional nanoparticles for cancer treatment |
| title_full_unstemmed | Tumor vasculature vs tumor cell targeting: Understanding the latest trends in using functional nanoparticles for cancer treatment |
| title_short | Tumor vasculature vs tumor cell targeting: Understanding the latest trends in using functional nanoparticles for cancer treatment |
| title_sort | Tumor vasculature vs tumor cell targeting: Understanding the latest trends in using functional nanoparticles for cancer treatment |
| topic | Tumor vasculature Cell targeting Tumor Nanoparticles Cancer treatment |
| url | http://hdl.handle.net/11073/25146 |