Gold-Nanoparticle Hybrid Nanostructures for Multimodal Cancer Therapy
With the urgent need for bio-nanomaterials to improve the currently available cancer treatments, gold nanoparticle (GNP) hybrid nanostructures are rapidly rising as promising multimodal candidates for cancer therapy. Gold nanoparticles (GNPs) have been hybridized with several nanocarriers, including...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , |
| التنسيق: | article |
| منشور في: |
2022
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/11073/25039 |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513441583071232 |
|---|---|
| author | Ali, Amaal Abdulraqeb |
| author2 | Abuwatfa, Waad Hussein Al-Sayah, Mohammad Husseini, Ghaleb |
| author2_role | author author author |
| author_facet | Ali, Amaal Abdulraqeb Abuwatfa, Waad Hussein Al-Sayah, Mohammad Husseini, Ghaleb |
| author_role | author |
| dc.creator.none.fl_str_mv | Ali, Amaal Abdulraqeb Abuwatfa, Waad Hussein Al-Sayah, Mohammad Husseini, Ghaleb |
| dc.date.none.fl_str_mv | 2022-10-24T04:43:28Z 2022-10-24T04:43:28Z 2022 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Ali, A.A.; Abuwatfa, W.H.; Al-Sayah, M.H.; Husseini, G.A. Gold-Nanoparticle Hybrid Nanostructures for Multimodal Cancer Therapy. Nanomaterials 2022, 12, 3706. https://doi.org/10.3390/nano12203706 2079-4991 http://hdl.handle.net/11073/25039 10.3390/nano12203706 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | MDPI |
| dc.relation.none.fl_str_mv | https://doi.org/10.3390/nano12203706 |
| dc.subject.none.fl_str_mv | Gold-nanoparticle hybrid nanostructures Multimodal therapy Photothermal therapy Triggered drug delivery |
| dc.title.none.fl_str_mv | Gold-Nanoparticle Hybrid Nanostructures for Multimodal Cancer Therapy |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | With the urgent need for bio-nanomaterials to improve the currently available cancer treatments, gold nanoparticle (GNP) hybrid nanostructures are rapidly rising as promising multimodal candidates for cancer therapy. Gold nanoparticles (GNPs) have been hybridized with several nanocarriers, including liposomes and polymers, to achieve chemotherapy, photothermal therapy, radiotherapy, and imaging using a single composite. The GNP nanohybrids used for targeted chemotherapy can be designed to respond to external stimuli such as heat or internal stimuli such as intratumoral pH. Despite their promise for multimodal cancer therapy, there are currently no reviews summarizing the current status of GNP nanohybrid use for cancer theragnostics. Therefore, this review fulfills this gap in the literature by providing a critical analysis of the data available on the use of GNP nanohybrids for cancer treatment with a specific focus on synergistic approaches (i.e., triggered drug release, photothermal therapy, and radiotherapy). It also highlights some of the challenges that hinder the clinical translation of GNP hybrid nanostructures from bench to bedside. Future studies that could expedite the clinical progress of GNPs, as well as the future possibility of improving GNP nanohybrids for cancer theragnostics, are also summarized. |
| format | article |
| id | aus_34dbead2cf38fd6c2124b4b57bae3e37 |
| identifier_str_mv | Ali, A.A.; Abuwatfa, W.H.; Al-Sayah, M.H.; Husseini, G.A. Gold-Nanoparticle Hybrid Nanostructures for Multimodal Cancer Therapy. Nanomaterials 2022, 12, 3706. https://doi.org/10.3390/nano12203706 2079-4991 10.3390/nano12203706 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/25039 |
| publishDate | 2022 |
| publisher.none.fl_str_mv | MDPI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Gold-Nanoparticle Hybrid Nanostructures for Multimodal Cancer TherapyAli, Amaal AbdulraqebAbuwatfa, Waad HusseinAl-Sayah, MohammadHusseini, GhalebGold-nanoparticle hybrid nanostructuresMultimodal therapyPhotothermal therapyTriggered drug deliveryWith the urgent need for bio-nanomaterials to improve the currently available cancer treatments, gold nanoparticle (GNP) hybrid nanostructures are rapidly rising as promising multimodal candidates for cancer therapy. Gold nanoparticles (GNPs) have been hybridized with several nanocarriers, including liposomes and polymers, to achieve chemotherapy, photothermal therapy, radiotherapy, and imaging using a single composite. The GNP nanohybrids used for targeted chemotherapy can be designed to respond to external stimuli such as heat or internal stimuli such as intratumoral pH. Despite their promise for multimodal cancer therapy, there are currently no reviews summarizing the current status of GNP nanohybrid use for cancer theragnostics. Therefore, this review fulfills this gap in the literature by providing a critical analysis of the data available on the use of GNP nanohybrids for cancer treatment with a specific focus on synergistic approaches (i.e., triggered drug release, photothermal therapy, and radiotherapy). It also highlights some of the challenges that hinder the clinical translation of GNP hybrid nanostructures from bench to bedside. Future studies that could expedite the clinical progress of GNPs, as well as the future possibility of improving GNP nanohybrids for cancer theragnostics, are also summarized.Dana Gas Endowed Chair for Chemical EngineeringAmerican University of SharjahSheikh Hamdan Award for Medical SciencesFriends of Cancer Patients (FoCP)MDPI2022-10-24T04:43:28Z2022-10-24T04:43:28Z2022Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfAli, A.A.; Abuwatfa, W.H.; Al-Sayah, M.H.; Husseini, G.A. Gold-Nanoparticle Hybrid Nanostructures for Multimodal Cancer Therapy. Nanomaterials 2022, 12, 3706. https://doi.org/10.3390/nano122037062079-4991http://hdl.handle.net/11073/2503910.3390/nano12203706en_UShttps://doi.org/10.3390/nano12203706oai:repository.aus.edu:11073/250392024-08-22T12:04:59Z |
| spellingShingle | Gold-Nanoparticle Hybrid Nanostructures for Multimodal Cancer Therapy Ali, Amaal Abdulraqeb Gold-nanoparticle hybrid nanostructures Multimodal therapy Photothermal therapy Triggered drug delivery |
| status_str | publishedVersion |
| title | Gold-Nanoparticle Hybrid Nanostructures for Multimodal Cancer Therapy |
| title_full | Gold-Nanoparticle Hybrid Nanostructures for Multimodal Cancer Therapy |
| title_fullStr | Gold-Nanoparticle Hybrid Nanostructures for Multimodal Cancer Therapy |
| title_full_unstemmed | Gold-Nanoparticle Hybrid Nanostructures for Multimodal Cancer Therapy |
| title_short | Gold-Nanoparticle Hybrid Nanostructures for Multimodal Cancer Therapy |
| title_sort | Gold-Nanoparticle Hybrid Nanostructures for Multimodal Cancer Therapy |
| topic | Gold-nanoparticle hybrid nanostructures Multimodal therapy Photothermal therapy Triggered drug delivery |
| url | http://hdl.handle.net/11073/25039 |