Modeling the Effects of Chemotherapy and Immunotherapy on Tumor Growth
Mathematical modeling has been used to simulate the interaction of chemotherapy and immunotherapy drugs intervention with the dynamics of tumor cells growth. This work studies the interaction of cells in the immune system, such as the natural killer, dendritic, and cytotoxic CD8+ T cells, with chemo...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , , , |
| التنسيق: | article |
| منشور في: |
2021
|
| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/11073/21581 |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513443755720705 |
|---|---|
| author | El Haout, Sara |
| author2 | Fatani, Maymunah Abu Farha, Nadia Khalil Mohammad AlSawaftah, Nour Majdi Mortula, Maruf Husseini, Ghaleb |
| author2_role | author author author author author |
| author_facet | El Haout, Sara Fatani, Maymunah Abu Farha, Nadia Khalil Mohammad AlSawaftah, Nour Majdi Mortula, Maruf Husseini, Ghaleb |
| author_role | author |
| dc.creator.none.fl_str_mv | El Haout, Sara Fatani, Maymunah Abu Farha, Nadia Khalil Mohammad AlSawaftah, Nour Majdi Mortula, Maruf Husseini, Ghaleb |
| dc.date.none.fl_str_mv | 2021-12-06T04:58:52Z 2021-12-06T04:58:52Z 2021 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | El Haout, S., Fatani, M., Abu Farha, N., AlSawaftah, N., Mortula, M., and Husseini, G. (2021). Modeling the Effects of Chemotherapy and Immunotherapy on Tumor Growth. Journal of Biomedical Nanotechnology,17(xx). doi:10.1166/jbn.2021.3214 1550-7041 http://hdl.handle.net/11073/21581 10.1166/jbn.2021.3214 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | American Scientific Publishers |
| dc.relation.none.fl_str_mv | https://doi:10.1166/jbn.2021.3214 |
| dc.subject.none.fl_str_mv | Tumor Growth Cancer Chemotherapy Immunotherapy Ordinary Differential Equation |
| dc.title.none.fl_str_mv | Modeling the Effects of Chemotherapy and Immunotherapy on Tumor Growth |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Mathematical modeling has been used to simulate the interaction of chemotherapy and immunotherapy drugs intervention with the dynamics of tumor cells growth. This work studies the interaction of cells in the immune system, such as the natural killer, dendritic, and cytotoxic CD8+ T cells, with chemotherapy. Four different cases were considered in the simulation: no drug intervention, independent interventions (either chemotherapy or immunotherapy), and combined interventions of chemotherapy and immunotherapy. The system of ordinary differential equations was initially solved using the Runge-Kutta method and compared with two additional methods: the Explicit Euler and Heun’s methods. Results showed that the combined intervention is more effective compared to the other cases. In addition, when compared with Runge-Kutta, the Heun’s method presented a better accuracy than the Explicit Euler technique. The proposed mathematical model can be used as a tool to improve cancer treatments and targeted therapy. |
| format | article |
| id | aus_35496335379fab2e13b3bdb046b01d16 |
| identifier_str_mv | El Haout, S., Fatani, M., Abu Farha, N., AlSawaftah, N., Mortula, M., and Husseini, G. (2021). Modeling the Effects of Chemotherapy and Immunotherapy on Tumor Growth. Journal of Biomedical Nanotechnology,17(xx). doi:10.1166/jbn.2021.3214 1550-7041 10.1166/jbn.2021.3214 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/21581 |
| publishDate | 2021 |
| publisher.none.fl_str_mv | American Scientific Publishers |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Modeling the Effects of Chemotherapy and Immunotherapy on Tumor GrowthEl Haout, SaraFatani, MaymunahAbu Farha, Nadia Khalil MohammadAlSawaftah, Nour MajdiMortula, MarufHusseini, GhalebTumor GrowthCancerChemotherapyImmunotherapyOrdinary Differential EquationMathematical modeling has been used to simulate the interaction of chemotherapy and immunotherapy drugs intervention with the dynamics of tumor cells growth. This work studies the interaction of cells in the immune system, such as the natural killer, dendritic, and cytotoxic CD8+ T cells, with chemotherapy. Four different cases were considered in the simulation: no drug intervention, independent interventions (either chemotherapy or immunotherapy), and combined interventions of chemotherapy and immunotherapy. The system of ordinary differential equations was initially solved using the Runge-Kutta method and compared with two additional methods: the Explicit Euler and Heun’s methods. Results showed that the combined intervention is more effective compared to the other cases. In addition, when compared with Runge-Kutta, the Heun’s method presented a better accuracy than the Explicit Euler technique. The proposed mathematical model can be used as a tool to improve cancer treatments and targeted therapy.American University of SharjahSheikh Hamdan Award for Medical SciencesAmerican Scientific Publishers2021-12-06T04:58:52Z2021-12-06T04:58:52Z2021Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfEl Haout, S., Fatani, M., Abu Farha, N., AlSawaftah, N., Mortula, M., and Husseini, G. (2021). Modeling the Effects of Chemotherapy and Immunotherapy on Tumor Growth. Journal of Biomedical Nanotechnology,17(xx). doi:10.1166/jbn.2021.32141550-7041http://hdl.handle.net/11073/2158110.1166/jbn.2021.3214en_UShttps://doi:10.1166/jbn.2021.3214oai:repository.aus.edu:11073/215812024-08-22T12:08:42Z |
| spellingShingle | Modeling the Effects of Chemotherapy and Immunotherapy on Tumor Growth El Haout, Sara Tumor Growth Cancer Chemotherapy Immunotherapy Ordinary Differential Equation |
| status_str | publishedVersion |
| title | Modeling the Effects of Chemotherapy and Immunotherapy on Tumor Growth |
| title_full | Modeling the Effects of Chemotherapy and Immunotherapy on Tumor Growth |
| title_fullStr | Modeling the Effects of Chemotherapy and Immunotherapy on Tumor Growth |
| title_full_unstemmed | Modeling the Effects of Chemotherapy and Immunotherapy on Tumor Growth |
| title_short | Modeling the Effects of Chemotherapy and Immunotherapy on Tumor Growth |
| title_sort | Modeling the Effects of Chemotherapy and Immunotherapy on Tumor Growth |
| topic | Tumor Growth Cancer Chemotherapy Immunotherapy Ordinary Differential Equation |
| url | http://hdl.handle.net/11073/21581 |