Ultrasonic Drug Delivery Using Micelles and Liposomes
The encapsulation of drugs in nanocarriers revolutionized research in drug delivery, especially in cancer chemotherapeutics. Several nanosystems have been developed including liposomes, polymeric micelles, dendrimers, solid lipid nanoparticles, and others. The surface of nanocarriers can be modified...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , |
| التنسيق: | bookPart |
| منشور في: |
2016
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/11073/21326 |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513434543980544 |
|---|---|
| author | Martins, Ana M. |
| author2 | Ahmed, Salma E. Vitor, Rute F. Husseini, Ghaleb |
| author2_role | author author author |
| author_facet | Martins, Ana M. Ahmed, Salma E. Vitor, Rute F. Husseini, Ghaleb |
| author_role | author |
| dc.creator.none.fl_str_mv | Martins, Ana M. Ahmed, Salma E. Vitor, Rute F. Husseini, Ghaleb |
| dc.date.none.fl_str_mv | 2016 2021-02-04T06:18:25Z 2021-02-04T06:18:25Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Martins A.M., Elgaili S.A., Vitor R.F., Husseini G.A. (2015) Ultrasonic Drug Delivery Using Micelles and Liposomes. In: Ashokkumar M. (eds) Handbook of Ultrasonics and Sonochemistry. Springer, Singapore. https://doi.org/10.1007/978-981-287-470-2_29-1 9789812874702 http://hdl.handle.net/11073/21326 10.1007/978-981-287-470-2_29-1 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | Springer |
| dc.relation.none.fl_str_mv | https://doi.org/10.1007/978-981-287-470-2_29-1 |
| dc.subject.none.fl_str_mv | Drug delivery systems (DDS) Pluronic® Polymeric micelles Triggered release Ultrasound (US) |
| dc.title.none.fl_str_mv | Ultrasonic Drug Delivery Using Micelles and Liposomes |
| dc.type.none.fl_str_mv | Postprint info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/bookPart |
| description | The encapsulation of drugs in nanocarriers revolutionized research in drug delivery, especially in cancer chemotherapeutics. Several nanosystems have been developed including liposomes, polymeric micelles, dendrimers, solid lipid nanoparticles, and others. The surface of nanocarriers can be modified to alter their characteristics and improve their efficiency as drug delivery systems. The addition of polyethylene glycol chains, for example, increases the blood circulation time of nanocapsules and, in some cases, improves their stability. Once the structure of nanocarriers is optimized, the next logical step is to explore the feasibility of using one or several trigger mechanisms to release their therapeutic contents at the required time and space. Abundant literature is available on both internal and external trigger mechanisms in cancer drug delivery. Internal mechanisms include changes in pH, enzyme concentration, and temperature, while external mechanisms include light, magnetic/electromagnetic waves, and acoustic power. This review focuses on the utility of ultrasound and polymeric micelles in cancer drug delivery. The idea is to control the release of chemotherapeutics from micelles to cancerous cells by focusing the ultrasound waves on the diseased tissue while sparing other healthy cells in the body. Thus, the side effects of conventional chemotherapy can be minimized. |
| format | bookPart |
| id | aus_38e182fce30f1313cae900c4190449db |
| identifier_str_mv | Martins A.M., Elgaili S.A., Vitor R.F., Husseini G.A. (2015) Ultrasonic Drug Delivery Using Micelles and Liposomes. In: Ashokkumar M. (eds) Handbook of Ultrasonics and Sonochemistry. Springer, Singapore. https://doi.org/10.1007/978-981-287-470-2_29-1 9789812874702 10.1007/978-981-287-470-2_29-1 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/21326 |
| publishDate | 2016 |
| publisher.none.fl_str_mv | Springer |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Ultrasonic Drug Delivery Using Micelles and LiposomesMartins, Ana M.Ahmed, Salma E.Vitor, Rute F.Husseini, GhalebDrug delivery systems (DDS)Pluronic®Polymeric micellesTriggered releaseUltrasound (US)The encapsulation of drugs in nanocarriers revolutionized research in drug delivery, especially in cancer chemotherapeutics. Several nanosystems have been developed including liposomes, polymeric micelles, dendrimers, solid lipid nanoparticles, and others. The surface of nanocarriers can be modified to alter their characteristics and improve their efficiency as drug delivery systems. The addition of polyethylene glycol chains, for example, increases the blood circulation time of nanocapsules and, in some cases, improves their stability. Once the structure of nanocarriers is optimized, the next logical step is to explore the feasibility of using one or several trigger mechanisms to release their therapeutic contents at the required time and space. Abundant literature is available on both internal and external trigger mechanisms in cancer drug delivery. Internal mechanisms include changes in pH, enzyme concentration, and temperature, while external mechanisms include light, magnetic/electromagnetic waves, and acoustic power. This review focuses on the utility of ultrasound and polymeric micelles in cancer drug delivery. The idea is to control the release of chemotherapeutics from micelles to cancerous cells by focusing the ultrasound waves on the diseased tissue while sparing other healthy cells in the body. Thus, the side effects of conventional chemotherapy can be minimized.Springer2021-02-04T06:18:25Z2021-02-04T06:18:25Z2016Postprintinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bookPartapplication/pdfMartins A.M., Elgaili S.A., Vitor R.F., Husseini G.A. (2015) Ultrasonic Drug Delivery Using Micelles and Liposomes. In: Ashokkumar M. (eds) Handbook of Ultrasonics and Sonochemistry. Springer, Singapore. https://doi.org/10.1007/978-981-287-470-2_29-19789812874702http://hdl.handle.net/11073/2132610.1007/978-981-287-470-2_29-1en_UShttps://doi.org/10.1007/978-981-287-470-2_29-1oai:repository.aus.edu:11073/213262024-08-22T12:06:10Z |
| spellingShingle | Ultrasonic Drug Delivery Using Micelles and Liposomes Martins, Ana M. Drug delivery systems (DDS) Pluronic® Polymeric micelles Triggered release Ultrasound (US) |
| status_str | publishedVersion |
| title | Ultrasonic Drug Delivery Using Micelles and Liposomes |
| title_full | Ultrasonic Drug Delivery Using Micelles and Liposomes |
| title_fullStr | Ultrasonic Drug Delivery Using Micelles and Liposomes |
| title_full_unstemmed | Ultrasonic Drug Delivery Using Micelles and Liposomes |
| title_short | Ultrasonic Drug Delivery Using Micelles and Liposomes |
| title_sort | Ultrasonic Drug Delivery Using Micelles and Liposomes |
| topic | Drug delivery systems (DDS) Pluronic® Polymeric micelles Triggered release Ultrasound (US) |
| url | http://hdl.handle.net/11073/21326 |