Transferrin‑modifed liposomes triggered with ultrasound to treat HeLa cells
Targeted liposomes are designed to target specific receptors overexpressed on the surfaces of cancer cells. This technique ensures site-specific drug delivery to reduce undesirable side effects while enhancing the efficiency of the encapsulated therapeutics. Upon reaching the tumor site, these lipos...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , |
| التنسيق: | article |
| منشور في: |
2021
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| الوصول للمادة أونلاين: | http://hdl.handle.net/11073/21491 |
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| _version_ | 1864513441591459840 |
|---|---|
| author | AlSawaftah, Nour Majdi |
| author2 | Awad, Nahid S. Paul, Vinod Kawak, Paul S. Al-Sayah, Mohammad Husseini, Ghaleb |
| author2_role | author author author author author |
| author_facet | AlSawaftah, Nour Majdi Awad, Nahid S. Paul, Vinod Kawak, Paul S. Al-Sayah, Mohammad Husseini, Ghaleb |
| author_role | author |
| dc.creator.none.fl_str_mv | AlSawaftah, Nour Majdi Awad, Nahid S. Paul, Vinod Kawak, Paul S. Al-Sayah, Mohammad Husseini, Ghaleb |
| dc.date.none.fl_str_mv | 2021-05-30T05:36:10Z 2021-05-30T05:36:10Z 2021 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | AlSawaftah, N. M., Awad, N. S., Paul, V., Kawak, P. S., Al-Sayah, M. H., Husseini, G. A. (2021). Transferrin‑modifed liposomes triggered with ultrasound to treat HeLa cells. Scientific Reports. https://doi.org/10.1038/s41598-021-90349-6 2045-2322 http://hdl.handle.net/11073/21491 10.1038/s41598-021-90349-6 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | Nature |
| dc.relation.none.fl_str_mv | https://doi.org/10.1038/s41598-021-90349-6 |
| dc.title.none.fl_str_mv | Transferrin‑modifed liposomes triggered with ultrasound to treat HeLa cells |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Targeted liposomes are designed to target specific receptors overexpressed on the surfaces of cancer cells. This technique ensures site-specific drug delivery to reduce undesirable side effects while enhancing the efficiency of the encapsulated therapeutics. Upon reaching the tumor site, these liposomes can be triggered to release their content in a controlled manner using ultrasound (US). In this study, drug release from pegylated calcein-loaded liposomes modified with transferrin (Tf) and triggered with US was evaluated. Low-frequency ultrasound at 20-kHz using three different power densities (6.2 mW/cm2, 9 mW/cm2 and 10 mW/cm2) was found to increase calcein release. In addition, transferrin-conjugated pegylated liposomes (Tf-PEG liposomes) were found to be more sonosensitive compared to the non-targeted (control) liposomes. Calcein uptake by HeLa cells was found to be significantly higher with the Tf-PEG liposomes compared to the non-targeted control liposomes. This uptake was further enhanced following the exposure to low-frequency ultrasound (at 35 kHz). These findings show that targeted liposomes triggered with US have promising potential as a safe and effective drug delivery platform. |
| format | article |
| id | aus_3bc96dc7768b1530efb78c2270f7d506 |
| identifier_str_mv | AlSawaftah, N. M., Awad, N. S., Paul, V., Kawak, P. S., Al-Sayah, M. H., Husseini, G. A. (2021). Transferrin‑modifed liposomes triggered with ultrasound to treat HeLa cells. Scientific Reports. https://doi.org/10.1038/s41598-021-90349-6 2045-2322 10.1038/s41598-021-90349-6 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/21491 |
| publishDate | 2021 |
| publisher.none.fl_str_mv | Nature |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Transferrin‑modifed liposomes triggered with ultrasound to treat HeLa cellsAlSawaftah, Nour MajdiAwad, Nahid S.Paul, VinodKawak, Paul S.Al-Sayah, MohammadHusseini, GhalebTargeted liposomes are designed to target specific receptors overexpressed on the surfaces of cancer cells. This technique ensures site-specific drug delivery to reduce undesirable side effects while enhancing the efficiency of the encapsulated therapeutics. Upon reaching the tumor site, these liposomes can be triggered to release their content in a controlled manner using ultrasound (US). In this study, drug release from pegylated calcein-loaded liposomes modified with transferrin (Tf) and triggered with US was evaluated. Low-frequency ultrasound at 20-kHz using three different power densities (6.2 mW/cm2, 9 mW/cm2 and 10 mW/cm2) was found to increase calcein release. In addition, transferrin-conjugated pegylated liposomes (Tf-PEG liposomes) were found to be more sonosensitive compared to the non-targeted (control) liposomes. Calcein uptake by HeLa cells was found to be significantly higher with the Tf-PEG liposomes compared to the non-targeted control liposomes. This uptake was further enhanced following the exposure to low-frequency ultrasound (at 35 kHz). These findings show that targeted liposomes triggered with US have promising potential as a safe and effective drug delivery platform.American University of SharjahPatient's Friends Committee-SharjahAl-Jalila FoundationAl Qasimi FoundationTechnology Innovation Pioneer (TIP) Healthcare AwardsDana Gas Endowed Chair for Chemical EngineeringNature2021-05-30T05:36:10Z2021-05-30T05:36:10Z2021Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfAlSawaftah, N. M., Awad, N. S., Paul, V., Kawak, P. S., Al-Sayah, M. H., Husseini, G. A. (2021). Transferrin‑modifed liposomes triggered with ultrasound to treat HeLa cells. Scientific Reports. https://doi.org/10.1038/s41598-021-90349-62045-2322http://hdl.handle.net/11073/2149110.1038/s41598-021-90349-6en_UShttps://doi.org/10.1038/s41598-021-90349-6oai:repository.aus.edu:11073/214912024-08-22T12:04:59Z |
| spellingShingle | Transferrin‑modifed liposomes triggered with ultrasound to treat HeLa cells AlSawaftah, Nour Majdi |
| status_str | publishedVersion |
| title | Transferrin‑modifed liposomes triggered with ultrasound to treat HeLa cells |
| title_full | Transferrin‑modifed liposomes triggered with ultrasound to treat HeLa cells |
| title_fullStr | Transferrin‑modifed liposomes triggered with ultrasound to treat HeLa cells |
| title_full_unstemmed | Transferrin‑modifed liposomes triggered with ultrasound to treat HeLa cells |
| title_short | Transferrin‑modifed liposomes triggered with ultrasound to treat HeLa cells |
| title_sort | Transferrin‑modifed liposomes triggered with ultrasound to treat HeLa cells |
| url | http://hdl.handle.net/11073/21491 |