Incorporating nanoparticles in 3D printed scaffolds for bone cancer therapy
The low occurrence rate of bone cancer contributes to delayed diagnosis and treatment; in addition, the surgical resection of bone tumors can cause significant bone defects, further hindering the effective treatment of the disease. 3D printing can help overcome some of these limitations by enabling...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , |
| التنسيق: | article |
| منشور في: |
2023
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/11073/25398 |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513438832656384 |
|---|---|
| author | AlSawaftah, Nour Majdi |
| author2 | Pitt, William G. Husseini, Ghaleb |
| author2_role | author author |
| author_facet | AlSawaftah, Nour Majdi Pitt, William G. Husseini, Ghaleb |
| author_role | author |
| dc.creator.none.fl_str_mv | AlSawaftah, Nour Majdi Pitt, William G. Husseini, Ghaleb |
| dc.date.none.fl_str_mv | 2023-11-07T07:08:43Z 2023-11-07T07:08:43Z 2023 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Al Sawaftah, N.; Pitt, W.; Husseini, G.; Incorporating nanoparticles in 3D printed scaffolds for bone cancer therapy, Bioprinting, Volume 36, 2023, e00322, ISSN 2405-8866, https://doi.org/10.1016/j.bprint.2023.e00322. 2405-8866 http://hdl.handle.net/11073/25398 10.1016/j.bprint.2023.e00322 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.relation.none.fl_str_mv | https://doi.org/10.1016/j.bprint.2023.e00322 |
| dc.subject.none.fl_str_mv | Bone cancer Cancer therapy Nanoparticles 3D printing Stimulus |
| dc.title.none.fl_str_mv | Incorporating nanoparticles in 3D printed scaffolds for bone cancer therapy |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | The low occurrence rate of bone cancer contributes to delayed diagnosis and treatment; in addition, the surgical resection of bone tumors can cause significant bone defects, further hindering the effective treatment of the disease. 3D printing can help overcome some of these limitations by enabling the design and fabrication of innovative scaffolds loaded with chemotherapeutics and growth factors, stimulating bone regeneration, and delivering targeted cancer treatment. Moreover, advancements in nanotechnology have opened up new possibilities for bone tissue engineering. Nanoparticles (NPs) possess size-dependent physicochemical properties. NPs can also be designed to respond to specific stimuli enhancing localized drug delivery. These unique properties can be harnessed by embedding NPs in 3D-printed scaffolds to develop multifunctional bone scaffolds with enhanced mechanical properties and drug delivery capabilities. This review evaluates the impact of incorporating NPs in 3D-printed scaffolds on bone cancer therapy and bone regeneration. First, various 3D printing techniques employed in the biomedical field are presented and explained. The article then highlights notable achievements by researchers in this area. Finally, the review discusses the current obstacles facing this technology and how they can be addressed to enable translation into clinics. |
| format | article |
| id | aus_3d0099d716653f2c311fad4b2ca97a7f |
| identifier_str_mv | Al Sawaftah, N.; Pitt, W.; Husseini, G.; Incorporating nanoparticles in 3D printed scaffolds for bone cancer therapy, Bioprinting, Volume 36, 2023, e00322, ISSN 2405-8866, https://doi.org/10.1016/j.bprint.2023.e00322. 2405-8866 10.1016/j.bprint.2023.e00322 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/25398 |
| publishDate | 2023 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
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| spelling | Incorporating nanoparticles in 3D printed scaffolds for bone cancer therapyAlSawaftah, Nour MajdiPitt, William G.Husseini, GhalebBone cancerCancer therapyNanoparticles3D printingStimulusThe low occurrence rate of bone cancer contributes to delayed diagnosis and treatment; in addition, the surgical resection of bone tumors can cause significant bone defects, further hindering the effective treatment of the disease. 3D printing can help overcome some of these limitations by enabling the design and fabrication of innovative scaffolds loaded with chemotherapeutics and growth factors, stimulating bone regeneration, and delivering targeted cancer treatment. Moreover, advancements in nanotechnology have opened up new possibilities for bone tissue engineering. Nanoparticles (NPs) possess size-dependent physicochemical properties. NPs can also be designed to respond to specific stimuli enhancing localized drug delivery. These unique properties can be harnessed by embedding NPs in 3D-printed scaffolds to develop multifunctional bone scaffolds with enhanced mechanical properties and drug delivery capabilities. This review evaluates the impact of incorporating NPs in 3D-printed scaffolds on bone cancer therapy and bone regeneration. First, various 3D printing techniques employed in the biomedical field are presented and explained. The article then highlights notable achievements by researchers in this area. Finally, the review discusses the current obstacles facing this technology and how they can be addressed to enable translation into clinics.American University of SharjahAl-Jalila FoundationAl Qasimi FoundationPatient’s Friends Committee-SharjahBiosciences and Bioengineering Research InstituteGCC Co-Fund ProgramTakamul programTechnology Innovation Pioneer (TIP) Healthcare AwardsSheikh Hamdan Award for Medical SciencesDana Gas Endowed Chair for Chemical EngineeringElsevier2023-11-07T07:08:43Z2023-11-07T07:08:43Z2023Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfAl Sawaftah, N.; Pitt, W.; Husseini, G.; Incorporating nanoparticles in 3D printed scaffolds for bone cancer therapy, Bioprinting, Volume 36, 2023, e00322, ISSN 2405-8866, https://doi.org/10.1016/j.bprint.2023.e00322.2405-8866http://hdl.handle.net/11073/2539810.1016/j.bprint.2023.e00322en_UShttps://doi.org/10.1016/j.bprint.2023.e00322oai:repository.aus.edu:11073/253982024-08-22T12:03:52Z |
| spellingShingle | Incorporating nanoparticles in 3D printed scaffolds for bone cancer therapy AlSawaftah, Nour Majdi Bone cancer Cancer therapy Nanoparticles 3D printing Stimulus |
| status_str | publishedVersion |
| title | Incorporating nanoparticles in 3D printed scaffolds for bone cancer therapy |
| title_full | Incorporating nanoparticles in 3D printed scaffolds for bone cancer therapy |
| title_fullStr | Incorporating nanoparticles in 3D printed scaffolds for bone cancer therapy |
| title_full_unstemmed | Incorporating nanoparticles in 3D printed scaffolds for bone cancer therapy |
| title_short | Incorporating nanoparticles in 3D printed scaffolds for bone cancer therapy |
| title_sort | Incorporating nanoparticles in 3D printed scaffolds for bone cancer therapy |
| topic | Bone cancer Cancer therapy Nanoparticles 3D printing Stimulus |
| url | http://hdl.handle.net/11073/25398 |