Immunomodulatory and Anti-Inflammatory Effects of Berberine in Lung Tissue and its Potential Application in Prophylaxis and Treatment of COVID-19
Natural products with known safety profiles are a promising source for the discovery of new drug leads. Berberine presents an example of one such phytochemical that has been extensively studied for its anti-inflammatory and immunomodulatory properties against myriads of diseases, ranging from respir...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , |
| التنسيق: | article |
| منشور في: |
2022
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/11073/25041 |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513442912665600 |
|---|---|
| author | Majdalawieh, Amin |
| author2 | Yousef, Sarah M. Abu-Yousef, Imad Nasrallah, Gheyath K. |
| author2_role | author author author |
| author_facet | Majdalawieh, Amin Yousef, Sarah M. Abu-Yousef, Imad Nasrallah, Gheyath K. |
| author_role | author |
| dc.creator.none.fl_str_mv | Majdalawieh, Amin Yousef, Sarah M. Abu-Yousef, Imad Nasrallah, Gheyath K. |
| dc.date.none.fl_str_mv | 2022-10-24T05:32:14Z 2022-10-24T05:32:14Z 2022 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Amin F. Majdalawieh, Sarah M. Yousef, Imad A. Abu-Yousef, Gheyath K. Nasrallah. Immunomodulatory and Anti-Inflammatory Effects of Berberine in Lung Tissue and its Potential Application in Prophylaxis and Treatment of COVID-19. Front. Biosci. (Landmark Ed) 2022, 27(5), 166. https://doi.org/10.31083/j.fbl2705166 2768-6698 http://hdl.handle.net/11073/25041 10.31083/j.fbl2705166 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | IMR Press |
| dc.relation.none.fl_str_mv | https://doi.org/10.31083/j.fbl2705166 |
| dc.subject.none.fl_str_mv | Berberine COVID-19 SARS-CoV-2 Anti-inflammatory Immunomodulatory Cytokine storm Th1/Th2 balance |
| dc.title.none.fl_str_mv | Immunomodulatory and Anti-Inflammatory Effects of Berberine in Lung Tissue and its Potential Application in Prophylaxis and Treatment of COVID-19 |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Natural products with known safety profiles are a promising source for the discovery of new drug leads. Berberine presents an example of one such phytochemical that has been extensively studied for its anti-inflammatory and immunomodulatory properties against myriads of diseases, ranging from respiratory disorders to viral infections. A growing body of research supports the pluripotent therapeutic role berberine may play against the dreaded disease COVID-19. The exact pathophysiological features of COVID-19 are yet to be elucidated. However, compelling evidence suggests inflammation and immune dysregulations as major features of this disease. Being a potent immunomodulatory and anti-inflammatory agent, berberine may prove to be useful for the prevention and treatment of COVID-19. This review aims to revisit the pharmacological anti-inflammatory and immunomodulatory benefits of berberine on a multitude of respiratory infections, which like COVID-19, are known to adversely affect the airways and lungs. We speculate that berberine may help alleviate COVID-19 via preventing cytokine storm, restoring Th1/Th2 balance, and enhancing cell-mediated immunity. Furthermore, the role this promising phytochemical plays on other important inflammatory mediators involved in respiratory disorders will be underscored. We further highlight the role of berberine against COVID-19 by underscoring direct evidence from in silico, in vitro, and in vivo studies suggesting the inhibitory potential berberine may play against three critical SARS-CoV-2 targets, namely main protease, spike protein, and angiotensin-converting enzyme 2 receptor. Further preclinical and clinical trials are certainly required to further substantiate the efficacy and potency of berberine against COVID-19 in humans. |
| format | article |
| id | aus_40c9dd3303f442f166f9b32d3700780e |
| identifier_str_mv | Amin F. Majdalawieh, Sarah M. Yousef, Imad A. Abu-Yousef, Gheyath K. Nasrallah. Immunomodulatory and Anti-Inflammatory Effects of Berberine in Lung Tissue and its Potential Application in Prophylaxis and Treatment of COVID-19. Front. Biosci. (Landmark Ed) 2022, 27(5), 166. https://doi.org/10.31083/j.fbl2705166 2768-6698 10.31083/j.fbl2705166 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/25041 |
| publishDate | 2022 |
| publisher.none.fl_str_mv | IMR Press |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Immunomodulatory and Anti-Inflammatory Effects of Berberine in Lung Tissue and its Potential Application in Prophylaxis and Treatment of COVID-19Majdalawieh, AminYousef, Sarah M.Abu-Yousef, ImadNasrallah, Gheyath K.BerberineCOVID-19SARS-CoV-2Anti-inflammatoryImmunomodulatoryCytokine stormTh1/Th2 balanceNatural products with known safety profiles are a promising source for the discovery of new drug leads. Berberine presents an example of one such phytochemical that has been extensively studied for its anti-inflammatory and immunomodulatory properties against myriads of diseases, ranging from respiratory disorders to viral infections. A growing body of research supports the pluripotent therapeutic role berberine may play against the dreaded disease COVID-19. The exact pathophysiological features of COVID-19 are yet to be elucidated. However, compelling evidence suggests inflammation and immune dysregulations as major features of this disease. Being a potent immunomodulatory and anti-inflammatory agent, berberine may prove to be useful for the prevention and treatment of COVID-19. This review aims to revisit the pharmacological anti-inflammatory and immunomodulatory benefits of berberine on a multitude of respiratory infections, which like COVID-19, are known to adversely affect the airways and lungs. We speculate that berberine may help alleviate COVID-19 via preventing cytokine storm, restoring Th1/Th2 balance, and enhancing cell-mediated immunity. Furthermore, the role this promising phytochemical plays on other important inflammatory mediators involved in respiratory disorders will be underscored. We further highlight the role of berberine against COVID-19 by underscoring direct evidence from in silico, in vitro, and in vivo studies suggesting the inhibitory potential berberine may play against three critical SARS-CoV-2 targets, namely main protease, spike protein, and angiotensin-converting enzyme 2 receptor. Further preclinical and clinical trials are certainly required to further substantiate the efficacy and potency of berberine against COVID-19 in humans.IMR Press2022-10-24T05:32:14Z2022-10-24T05:32:14Z2022Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfAmin F. Majdalawieh, Sarah M. Yousef, Imad A. Abu-Yousef, Gheyath K. Nasrallah. Immunomodulatory and Anti-Inflammatory Effects of Berberine in Lung Tissue and its Potential Application in Prophylaxis and Treatment of COVID-19. Front. Biosci. (Landmark Ed) 2022, 27(5), 166. https://doi.org/10.31083/j.fbl27051662768-6698http://hdl.handle.net/11073/2504110.31083/j.fbl2705166en_UShttps://doi.org/10.31083/j.fbl2705166oai:repository.aus.edu:11073/250412024-08-22T12:00:13Z |
| spellingShingle | Immunomodulatory and Anti-Inflammatory Effects of Berberine in Lung Tissue and its Potential Application in Prophylaxis and Treatment of COVID-19 Majdalawieh, Amin Berberine COVID-19 SARS-CoV-2 Anti-inflammatory Immunomodulatory Cytokine storm Th1/Th2 balance |
| status_str | publishedVersion |
| title | Immunomodulatory and Anti-Inflammatory Effects of Berberine in Lung Tissue and its Potential Application in Prophylaxis and Treatment of COVID-19 |
| title_full | Immunomodulatory and Anti-Inflammatory Effects of Berberine in Lung Tissue and its Potential Application in Prophylaxis and Treatment of COVID-19 |
| title_fullStr | Immunomodulatory and Anti-Inflammatory Effects of Berberine in Lung Tissue and its Potential Application in Prophylaxis and Treatment of COVID-19 |
| title_full_unstemmed | Immunomodulatory and Anti-Inflammatory Effects of Berberine in Lung Tissue and its Potential Application in Prophylaxis and Treatment of COVID-19 |
| title_short | Immunomodulatory and Anti-Inflammatory Effects of Berberine in Lung Tissue and its Potential Application in Prophylaxis and Treatment of COVID-19 |
| title_sort | Immunomodulatory and Anti-Inflammatory Effects of Berberine in Lung Tissue and its Potential Application in Prophylaxis and Treatment of COVID-19 |
| topic | Berberine COVID-19 SARS-CoV-2 Anti-inflammatory Immunomodulatory Cytokine storm Th1/Th2 balance |
| url | http://hdl.handle.net/11073/25041 |