Dual-Targeting and Stimuli-Triggered Liposomal Drug Delivery in Cancer Treatment
The delivery of chemotherapeutics to solid tumors using smart drug delivery systems (SDDSs) takes advantage of the unique physiology of tumors (i.e., disordered structure, leaky vasculature, abnormal extracellular matrix (ECM), and limited lymphatic drainage) to deliver anti-cancer drugs with reduce...
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2021
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| Online Access: | http://hdl.handle.net/11073/21492 |
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| _version_ | 1864513443787177984 |
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| author | AlSawaftah, Nour Majdi |
| author2 | Pitt, William G. Husseini, Ghaleb |
| author2_role | author author |
| author_facet | AlSawaftah, Nour Majdi Pitt, William G. Husseini, Ghaleb |
| author_role | author |
| dc.creator.none.fl_str_mv | AlSawaftah, Nour Majdi Pitt, William G. Husseini, Ghaleb |
| dc.date.none.fl_str_mv | 2021-06-02T12:47:30Z 2021-06-02T12:47:30Z 2021 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in ACS Pharmacology & Translational Science, ©2021 American Chemical Society after peer review. To access the final edited and published work see https://doi.org/10.1021/acsptsci.1c00066 2575-9108 http://hdl.handle.net/11073/21492 10.1021/acsptsci.1c00066 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | American Chemical Society |
| dc.relation.none.fl_str_mv | https://doi.org/10.1021/acsptsci.1c00066 |
| dc.subject.none.fl_str_mv | Cancer Nanocarrier Targeted delivery Liposomes Active targeting Stimulus |
| dc.title.none.fl_str_mv | Dual-Targeting and Stimuli-Triggered Liposomal Drug Delivery in Cancer Treatment |
| dc.type.none.fl_str_mv | Peer-Reviewed Preprint info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | The delivery of chemotherapeutics to solid tumors using smart drug delivery systems (SDDSs) takes advantage of the unique physiology of tumors (i.e., disordered structure, leaky vasculature, abnormal extracellular matrix (ECM), and limited lymphatic drainage) to deliver anti-cancer drugs with reduced systemic side effects. Liposomes are the most promising of such SDDSs and have been well investigated for cancer therapy. To improve the specificity, bioavailability and anti-cancer efficacy of liposomes at the diseased sites, other strategies such as targeting ligands and stimulus-sensitive liposomes have been developed. This review highlights relevant surface functionalization techniques and stimuli-mediated drug release for enhanced delivery of anti-cancer agents at tumor sites, with a special focus on dual functionalization and design of multi-stimuli responsive liposomes. |
| format | article |
| id | aus_40cba9901c8d523ff0304208b48510b2 |
| identifier_str_mv | This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in ACS Pharmacology & Translational Science, ©2021 American Chemical Society after peer review. To access the final edited and published work see https://doi.org/10.1021/acsptsci.1c00066 2575-9108 10.1021/acsptsci.1c00066 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/21492 |
| publishDate | 2021 |
| publisher.none.fl_str_mv | American Chemical Society |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Dual-Targeting and Stimuli-Triggered Liposomal Drug Delivery in Cancer TreatmentAlSawaftah, Nour MajdiPitt, William G.Husseini, GhalebCancerNanocarrierTargeted deliveryLiposomesActive targetingStimulusThe delivery of chemotherapeutics to solid tumors using smart drug delivery systems (SDDSs) takes advantage of the unique physiology of tumors (i.e., disordered structure, leaky vasculature, abnormal extracellular matrix (ECM), and limited lymphatic drainage) to deliver anti-cancer drugs with reduced systemic side effects. Liposomes are the most promising of such SDDSs and have been well investigated for cancer therapy. To improve the specificity, bioavailability and anti-cancer efficacy of liposomes at the diseased sites, other strategies such as targeting ligands and stimulus-sensitive liposomes have been developed. This review highlights relevant surface functionalization techniques and stimuli-mediated drug release for enhanced delivery of anti-cancer agents at tumor sites, with a special focus on dual functionalization and design of multi-stimuli responsive liposomes.American University of SharjahAl-Jalila FoundationAl Qasimi FoundationPatient's Friends Committee-SharjahBiosciences and Bioengineering Research InstituteDana Gas Endowed Chair for Chemical EngineeringAmerican Chemical Society2021-06-02T12:47:30Z2021-06-02T12:47:30Z2021Peer-ReviewedPreprintinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfThis document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in ACS Pharmacology & Translational Science, ©2021 American Chemical Society after peer review. To access the final edited and published work see https://doi.org/10.1021/acsptsci.1c000662575-9108http://hdl.handle.net/11073/2149210.1021/acsptsci.1c00066en_UShttps://doi.org/10.1021/acsptsci.1c00066oai:repository.aus.edu:11073/214922024-08-22T12:06:04Z |
| spellingShingle | Dual-Targeting and Stimuli-Triggered Liposomal Drug Delivery in Cancer Treatment AlSawaftah, Nour Majdi Cancer Nanocarrier Targeted delivery Liposomes Active targeting Stimulus |
| status_str | publishedVersion |
| title | Dual-Targeting and Stimuli-Triggered Liposomal Drug Delivery in Cancer Treatment |
| title_full | Dual-Targeting and Stimuli-Triggered Liposomal Drug Delivery in Cancer Treatment |
| title_fullStr | Dual-Targeting and Stimuli-Triggered Liposomal Drug Delivery in Cancer Treatment |
| title_full_unstemmed | Dual-Targeting and Stimuli-Triggered Liposomal Drug Delivery in Cancer Treatment |
| title_short | Dual-Targeting and Stimuli-Triggered Liposomal Drug Delivery in Cancer Treatment |
| title_sort | Dual-Targeting and Stimuli-Triggered Liposomal Drug Delivery in Cancer Treatment |
| topic | Cancer Nanocarrier Targeted delivery Liposomes Active targeting Stimulus |
| url | http://hdl.handle.net/11073/21492 |