Scaffold‑based 3D cell culture models in cancer research
Three-dimensional (3D) cell cultures have emerged as valuable tools in cancer research, offering significant advantages over traditional two-dimensional (2D) cell culture systems. In 3D cell cultures, cancer cells are grown in an environment that more closely mimics the 3D architecture and complexit...
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2024
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| Online Access: | http://hdl.handle.net/11073/25433 |
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| _version_ | 1864513443734749184 |
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| author | Abuwatfa, Waad Hussein |
| author2 | Pitt, William G. Husseini, Ghaleb |
| author2_role | author author |
| author_facet | Abuwatfa, Waad Hussein Pitt, William G. Husseini, Ghaleb |
| author_role | author |
| dc.creator.none.fl_str_mv | Abuwatfa, Waad Hussein Pitt, William G. Husseini, Ghaleb |
| dc.date.none.fl_str_mv | 2024-01-29T06:30:50Z 2024-01-29T06:30:50Z 2024 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Abuwatfa, W.H., Pitt, W.G. & Husseini, G.A. Scaffold-based 3D cell culture models in cancer research. J Biomed Sci 31, 7 (2024). https://doi.org/10.1186/s12929-024-00994-y 1423-0127 http://hdl.handle.net/11073/25433 10.1186/s12929-024-00994-y |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | Springer Nature |
| dc.relation.none.fl_str_mv | https://doi.org/10.1186/s12929-024-00994-y |
| dc.subject.none.fl_str_mv | Three-dimensional (3D) cell culture Scaffolds Hydrogels Decellularized tissues Microfluidics Extracellular matrix (ECM) |
| dc.title.none.fl_str_mv | Scaffold‑based 3D cell culture models in cancer research |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Three-dimensional (3D) cell cultures have emerged as valuable tools in cancer research, offering significant advantages over traditional two-dimensional (2D) cell culture systems. In 3D cell cultures, cancer cells are grown in an environment that more closely mimics the 3D architecture and complexity of in vivo tumors. This approach has revolutionized cancer research by providing a more accurate representation of the tumor microenvironment (TME) and enabling the study of tumor behavior and response to therapies in a more physiologically relevant context. One of the key benefits of 3D cell culture in cancer research is the ability to recapitulate the complex interactions between cancer cells and their surrounding stroma. Tumors consist not only of cancer cells but also various other cell types, including stromal cells, immune cells, and blood vessels. These models bridge traditional 2D cell cultures and animal models, offering a cost-effective, scalable, and ethical alternative for preclinical research. As the field advances, 3D cell cultures are poised to play a pivotal role in understanding cancer biology and accelerating the development of effective anticancer therapies. This review article highlights the key advantages of 3D cell cultures, progress in the most common scaffold-based culturing techniques, pertinent literature on their applications in cancer research, and the ongoing challenges. |
| format | article |
| id | aus_41022abc7a2fe97d17909c673c09adff |
| identifier_str_mv | Abuwatfa, W.H., Pitt, W.G. & Husseini, G.A. Scaffold-based 3D cell culture models in cancer research. J Biomed Sci 31, 7 (2024). https://doi.org/10.1186/s12929-024-00994-y 1423-0127 10.1186/s12929-024-00994-y |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/25433 |
| publishDate | 2024 |
| publisher.none.fl_str_mv | Springer Nature |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Scaffold‑based 3D cell culture models in cancer researchAbuwatfa, Waad HusseinPitt, William G.Husseini, GhalebThree-dimensional (3D) cell cultureScaffoldsHydrogelsDecellularized tissuesMicrofluidicsExtracellular matrix (ECM)Three-dimensional (3D) cell cultures have emerged as valuable tools in cancer research, offering significant advantages over traditional two-dimensional (2D) cell culture systems. In 3D cell cultures, cancer cells are grown in an environment that more closely mimics the 3D architecture and complexity of in vivo tumors. This approach has revolutionized cancer research by providing a more accurate representation of the tumor microenvironment (TME) and enabling the study of tumor behavior and response to therapies in a more physiologically relevant context. One of the key benefits of 3D cell culture in cancer research is the ability to recapitulate the complex interactions between cancer cells and their surrounding stroma. Tumors consist not only of cancer cells but also various other cell types, including stromal cells, immune cells, and blood vessels. These models bridge traditional 2D cell cultures and animal models, offering a cost-effective, scalable, and ethical alternative for preclinical research. As the field advances, 3D cell cultures are poised to play a pivotal role in understanding cancer biology and accelerating the development of effective anticancer therapies. This review article highlights the key advantages of 3D cell cultures, progress in the most common scaffold-based culturing techniques, pertinent literature on their applications in cancer research, and the ongoing challenges.American University of SharjahAl-Jalila FoundationAl Qasimi FoundationPatient’s Friends Committee-SharjahBiosciences and Bioengineering Research InstituteGCC Co-Fund ProgramTakamul programSheikh Hamdan Award for Medical SciencesDana Gas Endowed Chair for Chemical EngineeringTechnology Innovation Pioneer (TIP)Springer Nature2024-01-29T06:30:50Z2024-01-29T06:30:50Z2024Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfAbuwatfa, W.H., Pitt, W.G. & Husseini, G.A. Scaffold-based 3D cell culture models in cancer research. J Biomed Sci 31, 7 (2024). https://doi.org/10.1186/s12929-024-00994-y1423-0127http://hdl.handle.net/11073/2543310.1186/s12929-024-00994-yen_UShttps://doi.org/10.1186/s12929-024-00994-yoai:repository.aus.edu:11073/254332024-08-22T12:06:01Z |
| spellingShingle | Scaffold‑based 3D cell culture models in cancer research Abuwatfa, Waad Hussein Three-dimensional (3D) cell culture Scaffolds Hydrogels Decellularized tissues Microfluidics Extracellular matrix (ECM) |
| status_str | publishedVersion |
| title | Scaffold‑based 3D cell culture models in cancer research |
| title_full | Scaffold‑based 3D cell culture models in cancer research |
| title_fullStr | Scaffold‑based 3D cell culture models in cancer research |
| title_full_unstemmed | Scaffold‑based 3D cell culture models in cancer research |
| title_short | Scaffold‑based 3D cell culture models in cancer research |
| title_sort | Scaffold‑based 3D cell culture models in cancer research |
| topic | Three-dimensional (3D) cell culture Scaffolds Hydrogels Decellularized tissues Microfluidics Extracellular matrix (ECM) |
| url | http://hdl.handle.net/11073/25433 |