Distribution of Doxorubicin in Rats Undergoing Ultrasonic Drug Delivery
Ultrasound (US) increases efficacy of drugs delivered from micelles, but the pharmacokinetics have not been studied previously. In this study, US was used to deliver doxorubicin (Dox) sequestered in micelles in an in vivo rat model with bilateral leg tumors. One of two frequencies with identical mec...
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| مؤلفون آخرون: | , , , , |
| التنسيق: | article |
| منشور في: |
2010
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/11073/21284 |
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| _version_ | 1864513438452023296 |
|---|---|
| author | Staples, Bryant J. |
| author2 | Pitt, William G. Roeder, Beverly L. Husseini, Ghaleb Rajeev, Deepthi Schaalje, G. Bruce |
| author2_role | author author author author author |
| author_facet | Staples, Bryant J. Pitt, William G. Roeder, Beverly L. Husseini, Ghaleb Rajeev, Deepthi Schaalje, G. Bruce |
| author_role | author |
| dc.creator.none.fl_str_mv | Staples, Bryant J. Pitt, William G. Roeder, Beverly L. Husseini, Ghaleb Rajeev, Deepthi Schaalje, G. Bruce |
| dc.date.none.fl_str_mv | 2010 2021-01-26T09:03:42Z 2021-01-26T09:03:42Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Staples BJ, Pitt WG, Roeder BL, Husseini GA, Rajeev D, Schaalje GB. Distribution of doxorubicin in rats undergoing ultrasonic drug delivery. J Pharm Sci. 2010 Jul;99(7):3122-31. doi: 10.1002/jps.22088. PMID: 20166203; PMCID: PMC4533826. 0022-3549 http://hdl.handle.net/11073/21284 10.1002/jps.22088 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.relation.none.fl_str_mv | https://doi.org/10.1002/jps.22088 |
| dc.subject.none.fl_str_mv | Ultrasound Drug delivery Doxorubicin Rat tumor model Pharmacokinetics |
| dc.title.none.fl_str_mv | Distribution of Doxorubicin in Rats Undergoing Ultrasonic Drug Delivery |
| dc.type.none.fl_str_mv | Peer-Reviewed Postprint info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Ultrasound (US) increases efficacy of drugs delivered from micelles, but the pharmacokinetics have not been studied previously. In this study, US was used to deliver doxorubicin (Dox) sequestered in micelles in an in vivo rat model with bilateral leg tumors. One of two frequencies with identical mechanical index and intensity was delivered for 15 min to one tumor immediately after systemic injection of micellar Dox. Pharmacokinetics in myocardium, liver, skeletal muscle, and tumors were measured for 1 week. When applied in combination with micellar Dox, the ultrasoincated tumor had higher Dox concentrations at 30 min, compared to bilateral noninsonated controls. Initially, concentrations were highest in heart and liver, but within 24 h they decreased significantly. From 24 h to 7 days, concentrations remained highest in tumors, regardless of whether they received US or not. Comparison of insonated and noninsonated tumors showed 50% more Dox in the insonated tumor at 30 min posttreatment. Four weekly treatment produced additional Dox accumulation in the myocardium but not in liver, skeletal leg muscle, or tumors compared to single treatment. Controls showed that neither US nor the empty carrier impacted tumor growth. This study shows that US causes more release of drug at the targeted tumor. © 2010 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 99:3122–3131, 2010 |
| format | article |
| id | aus_44dd45baed86c0be577a54b2eb3d830a |
| identifier_str_mv | Staples BJ, Pitt WG, Roeder BL, Husseini GA, Rajeev D, Schaalje GB. Distribution of doxorubicin in rats undergoing ultrasonic drug delivery. J Pharm Sci. 2010 Jul;99(7):3122-31. doi: 10.1002/jps.22088. PMID: 20166203; PMCID: PMC4533826. 0022-3549 10.1002/jps.22088 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/21284 |
| publishDate | 2010 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Distribution of Doxorubicin in Rats Undergoing Ultrasonic Drug DeliveryStaples, Bryant J.Pitt, William G.Roeder, Beverly L.Husseini, GhalebRajeev, DeepthiSchaalje, G. BruceUltrasoundDrug deliveryDoxorubicinRat tumor modelPharmacokineticsUltrasound (US) increases efficacy of drugs delivered from micelles, but the pharmacokinetics have not been studied previously. In this study, US was used to deliver doxorubicin (Dox) sequestered in micelles in an in vivo rat model with bilateral leg tumors. One of two frequencies with identical mechanical index and intensity was delivered for 15 min to one tumor immediately after systemic injection of micellar Dox. Pharmacokinetics in myocardium, liver, skeletal muscle, and tumors were measured for 1 week. When applied in combination with micellar Dox, the ultrasoincated tumor had higher Dox concentrations at 30 min, compared to bilateral noninsonated controls. Initially, concentrations were highest in heart and liver, but within 24 h they decreased significantly. From 24 h to 7 days, concentrations remained highest in tumors, regardless of whether they received US or not. Comparison of insonated and noninsonated tumors showed 50% more Dox in the insonated tumor at 30 min posttreatment. Four weekly treatment produced additional Dox accumulation in the myocardium but not in liver, skeletal leg muscle, or tumors compared to single treatment. Controls showed that neither US nor the empty carrier impacted tumor growth. This study shows that US causes more release of drug at the targeted tumor. © 2010 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 99:3122–3131, 2010Elsevier2021-01-26T09:03:42Z2021-01-26T09:03:42Z2010Peer-ReviewedPostprintinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfStaples BJ, Pitt WG, Roeder BL, Husseini GA, Rajeev D, Schaalje GB. Distribution of doxorubicin in rats undergoing ultrasonic drug delivery. J Pharm Sci. 2010 Jul;99(7):3122-31. doi: 10.1002/jps.22088. PMID: 20166203; PMCID: PMC4533826.0022-3549http://hdl.handle.net/11073/2128410.1002/jps.22088en_UShttps://doi.org/10.1002/jps.22088oai:repository.aus.edu:11073/212842024-08-22T12:06:19Z |
| spellingShingle | Distribution of Doxorubicin in Rats Undergoing Ultrasonic Drug Delivery Staples, Bryant J. Ultrasound Drug delivery Doxorubicin Rat tumor model Pharmacokinetics |
| status_str | publishedVersion |
| title | Distribution of Doxorubicin in Rats Undergoing Ultrasonic Drug Delivery |
| title_full | Distribution of Doxorubicin in Rats Undergoing Ultrasonic Drug Delivery |
| title_fullStr | Distribution of Doxorubicin in Rats Undergoing Ultrasonic Drug Delivery |
| title_full_unstemmed | Distribution of Doxorubicin in Rats Undergoing Ultrasonic Drug Delivery |
| title_short | Distribution of Doxorubicin in Rats Undergoing Ultrasonic Drug Delivery |
| title_sort | Distribution of Doxorubicin in Rats Undergoing Ultrasonic Drug Delivery |
| topic | Ultrasound Drug delivery Doxorubicin Rat tumor model Pharmacokinetics |
| url | http://hdl.handle.net/11073/21284 |