Investigation and Mathematical Modeling of Acoustic Release of Doxorubicin from Micelles
A Master of Science thesis in Chemical Engineering by Youssef Ashraf Alhariri entitled, “Investigation and Mathematical Modeling of Acoustic Release of Doxorubicin from Micelles”, submitted in May 2020. Thesis advisors is Ghaleb Husseini and Rana Sabouni. Soft copy is available (Thesis, Approval Sig...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| التنسيق: | doctoralThesis |
| منشور في: |
2020
|
| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/11073/19724 |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513443728457728 |
|---|---|
| author | Alhariri, Youssef Ashraf |
| author_facet | Alhariri, Youssef Ashraf |
| author_role | author |
| dc.contributor.none.fl_str_mv | Husseini, Ghaleb Sabouni, Rana |
| dc.creator.none.fl_str_mv | Alhariri, Youssef Ashraf |
| dc.date.none.fl_str_mv | 2020-08-25T05:15:24Z 2020-08-25T05:15:24Z 2020-05 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | 35.232-2020.25 http://hdl.handle.net/11073/19724 |
| dc.language.none.fl_str_mv | en_US |
| dc.subject.none.fl_str_mv | Cancer Micelles Targeting Moieties Pluronic P105 Folic acid |
| dc.title.none.fl_str_mv | Investigation and Mathematical Modeling of Acoustic Release of Doxorubicin from Micelles |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/doctoralThesis |
| description | A Master of Science thesis in Chemical Engineering by Youssef Ashraf Alhariri entitled, “Investigation and Mathematical Modeling of Acoustic Release of Doxorubicin from Micelles”, submitted in May 2020. Thesis advisors is Ghaleb Husseini and Rana Sabouni. Soft copy is available (Thesis, Approval Signatures, Completion Certificate, and AUS Archives Consent Form). |
| format | doctoralThesis |
| id | aus_499e9055fb29c3585544bc486ec44cc6 |
| identifier_str_mv | 35.232-2020.25 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/19724 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Investigation and Mathematical Modeling of Acoustic Release of Doxorubicin from MicellesAlhariri, Youssef AshrafCancerMicellesTargetingMoietiesPluronic P105Folic acidA Master of Science thesis in Chemical Engineering by Youssef Ashraf Alhariri entitled, “Investigation and Mathematical Modeling of Acoustic Release of Doxorubicin from Micelles”, submitted in May 2020. Thesis advisors is Ghaleb Husseini and Rana Sabouni. Soft copy is available (Thesis, Approval Signatures, Completion Certificate, and AUS Archives Consent Form).Given the growing concern over the increasing number of people diagnosed with cancer and the high prevalence of unwanted side effects associated with chemotherapy on healthy tissues, this thesis aims to provide better, safer, and more effective treatment modalities. In this work, a targeted nanocarrier is loaded with an anti-cancer drug. Results of ultrasound release experiments are used to compare the response of different micellar types to acoustic waves. The investigated micelles include non-targeted micelles, folated micelles, micelles stabilized using an interpenetrating network of N,Ndiethylacrylamide, and micelles formed using PEO-b-poly(NIPAAm-co-HEMAlactaten). Acoustic release of the chemotherapeutic drug Doxorubicin (DOX) from micelles, was investigated using both 70-kHz and 80-kHz ultrasound at the following power densities: 0.76, 2.389, 2.546, 3.540, 5.013, 5.432, and 5.914 W/cm2. Next, mathematical modeling is applied to capture drug release kinetics from these nanovehicles. The investigated models are zero-order, first-order, Higuchi, Hixon- Crowell, Korsmeyer-Peppas, Weibull, Baker-Lonsdale, and Hopfenberg. Using statistics and the rate constants deduced, the effects of temperature, power density, and micellar type on drug release were investigated. Results showed that the release from folated micelles is slightly higher compared to release from non-folated micelles. This may be due to the conjugation of the folate moiety, which renders the micelles more sensitive to ultrasound (sonosensitive), by reducing their stability. Moreover, an increase in any of the experimental variables (mechanical index, temperature, or power density) leads to an increase in the percent of drug released. Finally, the Higuchi model provided the best fit to the experimental data, which means that the acoustic data available conform to this model’s assumptions and release mechanism. In conclusion, using micelles as drug delivery carriers and ultrasound as a trigger modality may reduce the side effects associated with chemotherapy.College of EngineeringDepartment of Chemical EngineeringMaster of Science in Chemical Engineering (MSChE)Husseini, GhalebSabouni, Rana2020-08-25T05:15:24Z2020-08-25T05:15:24Z2020-05info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisapplication/pdf35.232-2020.25http://hdl.handle.net/11073/19724en_USoai:repository.aus.edu:11073/197242025-06-26T12:32:56Z |
| spellingShingle | Investigation and Mathematical Modeling of Acoustic Release of Doxorubicin from Micelles Alhariri, Youssef Ashraf Cancer Micelles Targeting Moieties Pluronic P105 Folic acid |
| status_str | publishedVersion |
| title | Investigation and Mathematical Modeling of Acoustic Release of Doxorubicin from Micelles |
| title_full | Investigation and Mathematical Modeling of Acoustic Release of Doxorubicin from Micelles |
| title_fullStr | Investigation and Mathematical Modeling of Acoustic Release of Doxorubicin from Micelles |
| title_full_unstemmed | Investigation and Mathematical Modeling of Acoustic Release of Doxorubicin from Micelles |
| title_short | Investigation and Mathematical Modeling of Acoustic Release of Doxorubicin from Micelles |
| title_sort | Investigation and Mathematical Modeling of Acoustic Release of Doxorubicin from Micelles |
| topic | Cancer Micelles Targeting Moieties Pluronic P105 Folic acid |
| url | http://hdl.handle.net/11073/19724 |