Drug Release via Ultrasound-Activated Nanocarriers for Cancer Treatment: A Review
Conventional cancer chemotherapy often struggles with safely and effectively delivering anticancer therapeutics to target tissues, frequently leading to dose-limiting toxicity and suboptimal therapeutic outcomes. This has created a need for novel therapies that offer greater efficacy, enhanced safet...
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2024
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| Online Access: | https://hdl.handle.net/11073/26273 |
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| _version_ | 1864513444845191168 |
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| author | Al Refaai, Khaled Armouch |
| author2 | AlSawaftah, Nour A. Abuwatfa, Waad Husseini, Ghaleb A. |
| author2_role | author author author |
| author_facet | Al Refaai, Khaled Armouch AlSawaftah, Nour A. Abuwatfa, Waad Husseini, Ghaleb A. |
| author_role | author |
| dc.creator.none.fl_str_mv | Al Refaai, Khaled Armouch AlSawaftah, Nour A. Abuwatfa, Waad Husseini, Ghaleb A. |
| dc.date.none.fl_str_mv | 2024-10-27 2025-08-20T09:52:33Z 2025-08-20T09:52:33Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Al Refaai, K. A., AlSawaftah, N. A., Abuwatfa, W., & Husseini, G. A. (2024). Drug Release via Ultrasound-Activated Nanocarriers for Cancer Treatment: A Review. Pharmaceutics, 16(11), 1383. https://doi.org/10.3390/pharmaceutics16111383 1999-4923 https://hdl.handle.net/11073/26273 10.3390/pharmaceutics16111383 |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | MDPI |
| dc.relation.none.fl_str_mv | https://doi.org/10.3390/pharmaceutics16111383 |
| dc.rights.none.fl_str_mv | Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
| dc.subject.none.fl_str_mv | Nanocarriers Ultrasound Chemotherapy Ultrasound-induced drug release Nanomedicine Targeted drug delivery |
| dc.title.none.fl_str_mv | Drug Release via Ultrasound-Activated Nanocarriers for Cancer Treatment: A Review |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Conventional cancer chemotherapy often struggles with safely and effectively delivering anticancer therapeutics to target tissues, frequently leading to dose-limiting toxicity and suboptimal therapeutic outcomes. This has created a need for novel therapies that offer greater efficacy, enhanced safety, and improved toxicological profiles. Nanocarriers are nanosized particles specifically designed to enhance the selectivity and effectiveness of chemotherapy drugs while reducing their toxicity. A subset of drug delivery systems utilizes stimuli-responsive nanocarriers, which enable on-demand drug release, prevent premature release, and offer spatial and temporal control over drug delivery. These stimuli can be internal (such as pH and enzymes) or external (such as ultrasound, magnetic fields, and light). This review focuses on the mechanics of ultrasound-induced drug delivery and the various nanocarriers used in conjunction with ultrasound. It will also provide a comprehensive overview of key aspects related to ultrasound-induced drug delivery, including ultrasound parameters and the biological effects of ultrasound waves. |
| format | article |
| id | aus_508ae1331a5376fa9a4e2a5aa5a0ecc8 |
| identifier_str_mv | Al Refaai, K. A., AlSawaftah, N. A., Abuwatfa, W., & Husseini, G. A. (2024). Drug Release via Ultrasound-Activated Nanocarriers for Cancer Treatment: A Review. Pharmaceutics, 16(11), 1383. https://doi.org/10.3390/pharmaceutics16111383 1999-4923 10.3390/pharmaceutics16111383 |
| language_invalid_str_mv | en |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/26273 |
| publishDate | 2024 |
| publisher.none.fl_str_mv | MDPI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
| spelling | Drug Release via Ultrasound-Activated Nanocarriers for Cancer Treatment: A ReviewAl Refaai, Khaled ArmouchAlSawaftah, Nour A.Abuwatfa, WaadHusseini, Ghaleb A.NanocarriersUltrasoundChemotherapyUltrasound-induced drug releaseNanomedicineTargeted drug deliveryConventional cancer chemotherapy often struggles with safely and effectively delivering anticancer therapeutics to target tissues, frequently leading to dose-limiting toxicity and suboptimal therapeutic outcomes. This has created a need for novel therapies that offer greater efficacy, enhanced safety, and improved toxicological profiles. Nanocarriers are nanosized particles specifically designed to enhance the selectivity and effectiveness of chemotherapy drugs while reducing their toxicity. A subset of drug delivery systems utilizes stimuli-responsive nanocarriers, which enable on-demand drug release, prevent premature release, and offer spatial and temporal control over drug delivery. These stimuli can be internal (such as pH and enzymes) or external (such as ultrasound, magnetic fields, and light). This review focuses on the mechanics of ultrasound-induced drug delivery and the various nanocarriers used in conjunction with ultrasound. It will also provide a comprehensive overview of key aspects related to ultrasound-induced drug delivery, including ultrasound parameters and the biological effects of ultrasound waves.Dana Gas Endowed Chair for Chemical Engineering, American University of Sharjah Faculty Research Grants (FRG20-L-E48, FRG22-C-E08)Sheikh Hamdan Award for Medical Sciences MRG/18/2020Friends of Cancer Patients (FoCP)MDPI2025-08-20T09:52:33Z2025-08-20T09:52:33Z2024-10-27Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfAl Refaai, K. A., AlSawaftah, N. A., Abuwatfa, W., & Husseini, G. A. (2024). Drug Release via Ultrasound-Activated Nanocarriers for Cancer Treatment: A Review. Pharmaceutics, 16(11), 1383. https://doi.org/10.3390/pharmaceutics161113831999-4923https://hdl.handle.net/11073/2627310.3390/pharmaceutics16111383enhttps://doi.org/10.3390/pharmaceutics16111383Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/oai:repository.aus.edu:11073/262732025-08-20T18:27:32Z |
| spellingShingle | Drug Release via Ultrasound-Activated Nanocarriers for Cancer Treatment: A Review Al Refaai, Khaled Armouch Nanocarriers Ultrasound Chemotherapy Ultrasound-induced drug release Nanomedicine Targeted drug delivery |
| status_str | publishedVersion |
| title | Drug Release via Ultrasound-Activated Nanocarriers for Cancer Treatment: A Review |
| title_full | Drug Release via Ultrasound-Activated Nanocarriers for Cancer Treatment: A Review |
| title_fullStr | Drug Release via Ultrasound-Activated Nanocarriers for Cancer Treatment: A Review |
| title_full_unstemmed | Drug Release via Ultrasound-Activated Nanocarriers for Cancer Treatment: A Review |
| title_short | Drug Release via Ultrasound-Activated Nanocarriers for Cancer Treatment: A Review |
| title_sort | Drug Release via Ultrasound-Activated Nanocarriers for Cancer Treatment: A Review |
| topic | Nanocarriers Ultrasound Chemotherapy Ultrasound-induced drug release Nanomedicine Targeted drug delivery |
| url | https://hdl.handle.net/11073/26273 |