A Variational Bayesian-Based Correntropy Cubature Kalman Filter for Drug Release Estimation Using a Second-Order Model
Ultrasound-triggered liposomes designed for specific targeting show promise as a drug delivery system, with the potential to enhance the effectiveness of chemotherapy while minimizing related side effects in clinical settings. This paper aims to model the drug release rate of seven targeted liposome...
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2025
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| Online Access: | https://hdl.handle.net/11073/33246 |
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| _version_ | 1864513431874306048 |
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| author | Sarkis, Samer S. |
| author2 | Ismail, Sherif Wadi, Ali Abdel-Hafez, Mamoun Husseini, Ghaleb |
| author2_role | author author author author |
| author_facet | Sarkis, Samer S. Ismail, Sherif Wadi, Ali Abdel-Hafez, Mamoun Husseini, Ghaleb |
| author_role | author |
| dc.creator.none.fl_str_mv | Sarkis, Samer S. Ismail, Sherif Wadi, Ali Abdel-Hafez, Mamoun Husseini, Ghaleb |
| dc.date.none.fl_str_mv | 2025 2026-03-10T09:54:33Z 2026-03-10T09:54:33Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | S. S. Sarkis, S. Ismail, A. Wadi, M. F. Abdel-Hafez and G. A. Husseini, "A Variational Bayesian-Based Correntropy Cubature Kalman Filter for Drug Release Estimation Using a Second-Order Model," in IEEE Transactions on NanoBioscience, doi: 10.1109/TNB.2025.3641838. 1558-2639 https://hdl.handle.net/11073/33246 10.1109/TNB.2025.3641838 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | IEEE |
| dc.relation.none.fl_str_mv | https://doi.org/10.1109/TNB.2025.3641838 |
| dc.subject.none.fl_str_mv | Chemotherapy drug delivery systems Ultrasound Calcein release Online estimation Extended Kalman Filter Cubature Kalman Filter Variational Bayesian-Based Correntropy Cubature Kalman Filter |
| dc.title.none.fl_str_mv | A Variational Bayesian-Based Correntropy Cubature Kalman Filter for Drug Release Estimation Using a Second-Order Model |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Ultrasound-triggered liposomes designed for specific targeting show promise as a drug delivery system, with the potential to enhance the effectiveness of chemotherapy while minimizing related side effects in clinical settings. This paper aims to model the drug release rate of seven targeted liposomes using a second-order discrete equation rather than the previously used first-order equation. By modeling the rate as second-order, different variants of the Kalman Filter can be applied to estimate the drug release rate. After modeling the equations and fitting the data to a second-order model, the Kalman filter variants, including the Extended Kalman Filter (EKF), Cubature Kalman Filter (CKF), and the Variational Bayesian-Based Correntropy Cubature Kalman Filter (VBMCCKF), were used to estimate the drug release rate. By applying those variants, we can see that the VBMCCKF yields the best tracking performance, combining the VBKF’s adaptive estimation of measurement noise with the MCCKF’s setting of the filter gain to a very small value when an abnormal measurement is found. As a result, the VBMCCKF yielded the lowest Mean Squared Error (MSE) and Root Mean Squared Error (RMSE). |
| format | article |
| id | aus_51e86d7b0543a5a9167565fa60060246 |
| identifier_str_mv | S. S. Sarkis, S. Ismail, A. Wadi, M. F. Abdel-Hafez and G. A. Husseini, "A Variational Bayesian-Based Correntropy Cubature Kalman Filter for Drug Release Estimation Using a Second-Order Model," in IEEE Transactions on NanoBioscience, doi: 10.1109/TNB.2025.3641838. 1558-2639 10.1109/TNB.2025.3641838 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/33246 |
| publishDate | 2025 |
| publisher.none.fl_str_mv | IEEE |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | A Variational Bayesian-Based Correntropy Cubature Kalman Filter for Drug Release Estimation Using a Second-Order ModelSarkis, Samer S.Ismail, SherifWadi, AliAbdel-Hafez, MamounHusseini, GhalebChemotherapy drug delivery systemsUltrasoundCalcein releaseOnline estimationExtended Kalman FilterCubature Kalman FilterVariational Bayesian-Based Correntropy Cubature Kalman FilterUltrasound-triggered liposomes designed for specific targeting show promise as a drug delivery system, with the potential to enhance the effectiveness of chemotherapy while minimizing related side effects in clinical settings. This paper aims to model the drug release rate of seven targeted liposomes using a second-order discrete equation rather than the previously used first-order equation. By modeling the rate as second-order, different variants of the Kalman Filter can be applied to estimate the drug release rate. After modeling the equations and fitting the data to a second-order model, the Kalman filter variants, including the Extended Kalman Filter (EKF), Cubature Kalman Filter (CKF), and the Variational Bayesian-Based Correntropy Cubature Kalman Filter (VBMCCKF), were used to estimate the drug release rate. By applying those variants, we can see that the VBMCCKF yields the best tracking performance, combining the VBKF’s adaptive estimation of measurement noise with the MCCKF’s setting of the filter gain to a very small value when an abnormal measurement is found. As a result, the VBMCCKF yielded the lowest Mean Squared Error (MSE) and Root Mean Squared Error (RMSE).Friends of Cancer Patients (FoCP)Sheikh Hamdan Award for Medical SciencesAmerican University of SharjahDana Gas Endowed Chair for Chemical EngineeringIEEE2026-03-10T09:54:33Z2026-03-10T09:54:33Z2025Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfS. S. Sarkis, S. Ismail, A. Wadi, M. F. Abdel-Hafez and G. A. Husseini, "A Variational Bayesian-Based Correntropy Cubature Kalman Filter for Drug Release Estimation Using a Second-Order Model," in IEEE Transactions on NanoBioscience, doi: 10.1109/TNB.2025.3641838.1558-2639https://hdl.handle.net/11073/3324610.1109/TNB.2025.3641838en_UShttps://doi.org/10.1109/TNB.2025.3641838oai:repository.aus.edu:11073/332462026-03-11T05:27:07Z |
| spellingShingle | A Variational Bayesian-Based Correntropy Cubature Kalman Filter for Drug Release Estimation Using a Second-Order Model Sarkis, Samer S. Chemotherapy drug delivery systems Ultrasound Calcein release Online estimation Extended Kalman Filter Cubature Kalman Filter Variational Bayesian-Based Correntropy Cubature Kalman Filter |
| status_str | publishedVersion |
| title | A Variational Bayesian-Based Correntropy Cubature Kalman Filter for Drug Release Estimation Using a Second-Order Model |
| title_full | A Variational Bayesian-Based Correntropy Cubature Kalman Filter for Drug Release Estimation Using a Second-Order Model |
| title_fullStr | A Variational Bayesian-Based Correntropy Cubature Kalman Filter for Drug Release Estimation Using a Second-Order Model |
| title_full_unstemmed | A Variational Bayesian-Based Correntropy Cubature Kalman Filter for Drug Release Estimation Using a Second-Order Model |
| title_short | A Variational Bayesian-Based Correntropy Cubature Kalman Filter for Drug Release Estimation Using a Second-Order Model |
| title_sort | A Variational Bayesian-Based Correntropy Cubature Kalman Filter for Drug Release Estimation Using a Second-Order Model |
| topic | Chemotherapy drug delivery systems Ultrasound Calcein release Online estimation Extended Kalman Filter Cubature Kalman Filter Variational Bayesian-Based Correntropy Cubature Kalman Filter |
| url | https://hdl.handle.net/11073/33246 |