Combined and Single Doxorubicin/Naproxen Drug Loading and Dual-Responsive pH/Ultrasound Release from Flexible Metal-Organic Framework Nanocarriers
In this study, the flexible aluminum-based MIL-53(Al) metal-organic framework was loaded with doxorubicin (DOX) and naproxen (NAP) and was examined as a promising pH/ultrasound dual-responsive drug delivery system. The two drugs were encapsulated in MIL-53(Al) individually to produce the DOX@MIL-53(...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , |
| التنسيق: | article |
| منشور في: |
2022
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/11073/24292 |
| الوسوم: |
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| _version_ | 1864513433398935552 |
|---|---|
| author | Karami, Abdollah |
| author2 | Ahmed, Ahmed H.S Sabouni, Rana Husseini, Ghaleb Paul, Vinod |
| author2_role | author author author author |
| author_facet | Karami, Abdollah Ahmed, Ahmed H.S Sabouni, Rana Husseini, Ghaleb Paul, Vinod |
| author_role | author |
| dc.creator.none.fl_str_mv | Karami, Abdollah Ahmed, Ahmed H.S Sabouni, Rana Husseini, Ghaleb Paul, Vinod |
| dc.date.none.fl_str_mv | 2022-09-27T06:03:39Z 2022-09-27T06:03:39Z 2022 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Karami, A.; Ahmed, A.; Sabouni, R.; Husseini, G.; Paul, V. Combined and Single Doxorubicin/Naproxen Drug Loading and Dual-Responsive pH/Ultrasound Release from Flexible Metal-Organic Framework Nanocarriers. Journal of Biomedical Nanotechnology, 2022, Vol. 18, 1–12. https://doi.org/10.1166/jbn.2022.3381. 1550-7041 http://hdl.handle.net/11073/24292 10.1166/jbn.2022.3381 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | American Scientific Publishers |
| dc.relation.none.fl_str_mv | https://doi.org/10.1166/jbn.2022.3381 |
| dc.subject.none.fl_str_mv | Metal-Organic Frameworks (MOFs) Drug Delivery Drug Codelivery Ultrasound Triggered Release Stimuli-Responsive Nanocarriers Doxorubicin Naproxen MIL-53(Al) |
| dc.title.none.fl_str_mv | Combined and Single Doxorubicin/Naproxen Drug Loading and Dual-Responsive pH/Ultrasound Release from Flexible Metal-Organic Framework Nanocarriers |
| dc.type.none.fl_str_mv | Peer-Reviewed Postprint info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | In this study, the flexible aluminum-based MIL-53(Al) metal-organic framework was loaded with doxorubicin (DOX) and naproxen (NAP) and was examined as a promising pH/ultrasound dual-responsive drug delivery system. The two drugs were encapsulated in MIL-53(Al) individually to produce the DOX@MIL-53(Al) and NAP@MIL-53(Al) nanocarriers. They were also encapsulated as a dual-drug formulation to produce the DOX* +NAP*@MIL-53(Al) nanocarrier. The MOF nanoparticles were characterized using the Scanning Electron Microscopy (SEM), X-ray diffraction (XRD), Fourier Trans- form Infrared spectroscopy (FTIR), and Dynamic Light Scattering (DLS) techniques. In the case of the DOX@MIL, the nanocarriers’ drug Encapsulation Efficiency (EE) and Encapsulation Capacity (EC) were 92% and 16 wt.%, respectively, whereas, in the case of NAP@MIL-53(Al), the average NAP EE and EC were around 97.7% and 8.5 wt.%, respectively. On the other hand, in the DOX* +NAP*@MIL-53(Al) nanoparticles, the average DOX* EE and EC were 38.9% and 6.22 wt.%, respectively, while for NAP*, the average EE and EC were 70.2% and 4.49 wt.%, respectively. In vitro release experiments demonstrated the good pH and Ultrasound (US) dual-responsiveness of these nanocarriers, with a maximum US-triggered DOX and NAP release, at a pH level of 7.4, of approximately 53% and 95%, respectively. In comparison, the measured release was around 90% and 36% at pH 5.3 for DOX and NAP, respectively. In the case of the dual-drug formulation, the nanocarrier displayed similar pH/US dual-responsive behavior. Finally, the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) results confirmed the biocompatibility and low cytotoxicity of MIL-53(Al) at concentrations up to 1000 µg/ml. |
| format | article |
| id | aus_598aaa177232383b028efdf4a062e73a |
| identifier_str_mv | Karami, A.; Ahmed, A.; Sabouni, R.; Husseini, G.; Paul, V. Combined and Single Doxorubicin/Naproxen Drug Loading and Dual-Responsive pH/Ultrasound Release from Flexible Metal-Organic Framework Nanocarriers. Journal of Biomedical Nanotechnology, 2022, Vol. 18, 1–12. https://doi.org/10.1166/jbn.2022.3381. 1550-7041 10.1166/jbn.2022.3381 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/24292 |
| publishDate | 2022 |
| publisher.none.fl_str_mv | American Scientific Publishers |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Combined and Single Doxorubicin/Naproxen Drug Loading and Dual-Responsive pH/Ultrasound Release from Flexible Metal-Organic Framework NanocarriersKarami, AbdollahAhmed, Ahmed H.SSabouni, RanaHusseini, GhalebPaul, VinodMetal-Organic Frameworks (MOFs)Drug DeliveryDrug CodeliveryUltrasoundTriggered ReleaseStimuli-Responsive NanocarriersDoxorubicinNaproxenMIL-53(Al)In this study, the flexible aluminum-based MIL-53(Al) metal-organic framework was loaded with doxorubicin (DOX) and naproxen (NAP) and was examined as a promising pH/ultrasound dual-responsive drug delivery system. The two drugs were encapsulated in MIL-53(Al) individually to produce the DOX@MIL-53(Al) and NAP@MIL-53(Al) nanocarriers. They were also encapsulated as a dual-drug formulation to produce the DOX* +NAP*@MIL-53(Al) nanocarrier. The MOF nanoparticles were characterized using the Scanning Electron Microscopy (SEM), X-ray diffraction (XRD), Fourier Trans- form Infrared spectroscopy (FTIR), and Dynamic Light Scattering (DLS) techniques. In the case of the DOX@MIL, the nanocarriers’ drug Encapsulation Efficiency (EE) and Encapsulation Capacity (EC) were 92% and 16 wt.%, respectively, whereas, in the case of NAP@MIL-53(Al), the average NAP EE and EC were around 97.7% and 8.5 wt.%, respectively. On the other hand, in the DOX* +NAP*@MIL-53(Al) nanoparticles, the average DOX* EE and EC were 38.9% and 6.22 wt.%, respectively, while for NAP*, the average EE and EC were 70.2% and 4.49 wt.%, respectively. In vitro release experiments demonstrated the good pH and Ultrasound (US) dual-responsiveness of these nanocarriers, with a maximum US-triggered DOX and NAP release, at a pH level of 7.4, of approximately 53% and 95%, respectively. In comparison, the measured release was around 90% and 36% at pH 5.3 for DOX and NAP, respectively. In the case of the dual-drug formulation, the nanocarrier displayed similar pH/US dual-responsive behavior. Finally, the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) results confirmed the biocompatibility and low cytotoxicity of MIL-53(Al) at concentrations up to 1000 µg/ml.American University of SharjahAmerican Scientific Publishers2022-09-27T06:03:39Z2022-09-27T06:03:39Z2022Peer-ReviewedPostprintinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfKarami, A.; Ahmed, A.; Sabouni, R.; Husseini, G.; Paul, V. Combined and Single Doxorubicin/Naproxen Drug Loading and Dual-Responsive pH/Ultrasound Release from Flexible Metal-Organic Framework Nanocarriers. Journal of Biomedical Nanotechnology, 2022, Vol. 18, 1–12. https://doi.org/10.1166/jbn.2022.3381.1550-7041http://hdl.handle.net/11073/2429210.1166/jbn.2022.3381en_UShttps://doi.org/10.1166/jbn.2022.3381oai:repository.aus.edu:11073/242922024-08-22T12:05:06Z |
| spellingShingle | Combined and Single Doxorubicin/Naproxen Drug Loading and Dual-Responsive pH/Ultrasound Release from Flexible Metal-Organic Framework Nanocarriers Karami, Abdollah Metal-Organic Frameworks (MOFs) Drug Delivery Drug Codelivery Ultrasound Triggered Release Stimuli-Responsive Nanocarriers Doxorubicin Naproxen MIL-53(Al) |
| status_str | publishedVersion |
| title | Combined and Single Doxorubicin/Naproxen Drug Loading and Dual-Responsive pH/Ultrasound Release from Flexible Metal-Organic Framework Nanocarriers |
| title_full | Combined and Single Doxorubicin/Naproxen Drug Loading and Dual-Responsive pH/Ultrasound Release from Flexible Metal-Organic Framework Nanocarriers |
| title_fullStr | Combined and Single Doxorubicin/Naproxen Drug Loading and Dual-Responsive pH/Ultrasound Release from Flexible Metal-Organic Framework Nanocarriers |
| title_full_unstemmed | Combined and Single Doxorubicin/Naproxen Drug Loading and Dual-Responsive pH/Ultrasound Release from Flexible Metal-Organic Framework Nanocarriers |
| title_short | Combined and Single Doxorubicin/Naproxen Drug Loading and Dual-Responsive pH/Ultrasound Release from Flexible Metal-Organic Framework Nanocarriers |
| title_sort | Combined and Single Doxorubicin/Naproxen Drug Loading and Dual-Responsive pH/Ultrasound Release from Flexible Metal-Organic Framework Nanocarriers |
| topic | Metal-Organic Frameworks (MOFs) Drug Delivery Drug Codelivery Ultrasound Triggered Release Stimuli-Responsive Nanocarriers Doxorubicin Naproxen MIL-53(Al) |
| url | http://hdl.handle.net/11073/24292 |