The Use of Ultrasound and Micelles in Cancer Treatment
The high toxicity of potent chemotherapeutic drugs like Doxorubicin (Dox) limits the therapeutic window in which they can be applied. This window can be expanded by controlling the drug delivery in both space and time such that non-targeted tissues are not adversely affected. Recent research has sho...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | |
| التنسيق: | article |
| منشور في: |
2008
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/11073/19733 |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513435906080768 |
|---|---|
| author | Husseini, Ghaleb |
| author2 | Pitt, William G. |
| author2_role | author |
| author_facet | Husseini, Ghaleb Pitt, William G. |
| author_role | author |
| dc.creator.none.fl_str_mv | Husseini, Ghaleb Pitt, William G. |
| dc.date.none.fl_str_mv | 2008 2020-08-27T10:37:44Z 2020-08-27T10:37:44Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Husseini, G. A., & Pitt, W. G. (2008). The use of ultrasound and micelles in cancer treatment. Journal of Nanoscience and Nanotechnology, 8(5), 2205–2215. https://doi.org/10.1166/jnn.2008.225 1533-4880 http://hdl.handle.net/11073/19733 10.1166/jnn.2008.225 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | American Scientific Publishers |
| dc.relation.none.fl_str_mv | https://doi.org/10.1166/jnn.2008.225 |
| dc.subject.none.fl_str_mv | Targeted Delivery Polymeric Micelles Ultrasound Drug Delivery Cancer |
| dc.title.none.fl_str_mv | The Use of Ultrasound and Micelles in Cancer Treatment |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | The high toxicity of potent chemotherapeutic drugs like Doxorubicin (Dox) limits the therapeutic window in which they can be applied. This window can be expanded by controlling the drug delivery in both space and time such that non-targeted tissues are not adversely affected. Recent research has shown that ultrasound (US) can be used to control the release of Dox and other hydrophobic drugs from polymeric micelles in both time and space. It has also been shown using an in vivo rat tumor model that Dox activity can be enhanced by ultrasound in one region, while in an adjacent region there is little or no effect of the drug. In this article, we review the in vivo and in vitro research being conducted in the area of using ultrasound to enhance and target micellar drug delivery to cancerous tissues. Additionally, we summarize our previously published mathematical models that attempt to represent the release and re-encapsulation phenomena of Dox from Pluronic® P105 micelles upon the application of ultrasound. The potential benefits of such controlled chemotherapy compels a thorough investigation of the role of ultrasound (US) and the mechanisms by which USaccomplishes drug release and/or enhances drug potency. Therefore we will summarize our findings related to the mechanism involved in acoustically activated micellar drug delivery to tumors. |
| format | article |
| id | aus_63c73cdc6c2bedc55f474db0da8cff02 |
| identifier_str_mv | Husseini, G. A., & Pitt, W. G. (2008). The use of ultrasound and micelles in cancer treatment. Journal of Nanoscience and Nanotechnology, 8(5), 2205–2215. https://doi.org/10.1166/jnn.2008.225 1533-4880 10.1166/jnn.2008.225 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/19733 |
| publishDate | 2008 |
| publisher.none.fl_str_mv | American Scientific Publishers |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | The Use of Ultrasound and Micelles in Cancer TreatmentHusseini, GhalebPitt, William G.Targeted DeliveryPolymeric MicellesUltrasoundDrug DeliveryCancerThe high toxicity of potent chemotherapeutic drugs like Doxorubicin (Dox) limits the therapeutic window in which they can be applied. This window can be expanded by controlling the drug delivery in both space and time such that non-targeted tissues are not adversely affected. Recent research has shown that ultrasound (US) can be used to control the release of Dox and other hydrophobic drugs from polymeric micelles in both time and space. It has also been shown using an in vivo rat tumor model that Dox activity can be enhanced by ultrasound in one region, while in an adjacent region there is little or no effect of the drug. In this article, we review the in vivo and in vitro research being conducted in the area of using ultrasound to enhance and target micellar drug delivery to cancerous tissues. Additionally, we summarize our previously published mathematical models that attempt to represent the release and re-encapsulation phenomena of Dox from Pluronic® P105 micelles upon the application of ultrasound. The potential benefits of such controlled chemotherapy compels a thorough investigation of the role of ultrasound (US) and the mechanisms by which USaccomplishes drug release and/or enhances drug potency. Therefore we will summarize our findings related to the mechanism involved in acoustically activated micellar drug delivery to tumors.American Scientific Publishers2020-08-27T10:37:44Z2020-08-27T10:37:44Z2008Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfHusseini, G. A., & Pitt, W. G. (2008). The use of ultrasound and micelles in cancer treatment. Journal of Nanoscience and Nanotechnology, 8(5), 2205–2215. https://doi.org/10.1166/jnn.2008.2251533-4880http://hdl.handle.net/11073/1973310.1166/jnn.2008.225en_UShttps://doi.org/10.1166/jnn.2008.225oai:repository.aus.edu:11073/197332024-08-22T12:04:47Z |
| spellingShingle | The Use of Ultrasound and Micelles in Cancer Treatment Husseini, Ghaleb Targeted Delivery Polymeric Micelles Ultrasound Drug Delivery Cancer |
| status_str | publishedVersion |
| title | The Use of Ultrasound and Micelles in Cancer Treatment |
| title_full | The Use of Ultrasound and Micelles in Cancer Treatment |
| title_fullStr | The Use of Ultrasound and Micelles in Cancer Treatment |
| title_full_unstemmed | The Use of Ultrasound and Micelles in Cancer Treatment |
| title_short | The Use of Ultrasound and Micelles in Cancer Treatment |
| title_sort | The Use of Ultrasound and Micelles in Cancer Treatment |
| topic | Targeted Delivery Polymeric Micelles Ultrasound Drug Delivery Cancer |
| url | http://hdl.handle.net/11073/19733 |