Investigating and Modeling the Acoustic Release of Doxorubicin from Folate Targeted Micelles
A Master of Science thesis in Chemical Engineering by Laura Kherbeck entitled, "Investigating and Modeling the Acoustic Release of Doxorubicin from Folate-Targeted Micelles," submitted in June 2012. Thesis advisor is Dr. Ghaleb Al Husaini. Available are both soft and hard copies of the the...
محفوظ في:
| المؤلف الرئيسي: | |
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| التنسيق: | doctoralThesis |
| منشور في: |
2012
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/11073/4075 |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513442404106240 |
|---|---|
| author | Kherbeck, Laura |
| author_facet | Kherbeck, Laura |
| author_role | author |
| dc.contributor.none.fl_str_mv | Husseini, Ghaleb |
| dc.creator.none.fl_str_mv | Kherbeck, Laura |
| dc.date.none.fl_str_mv | 2012-09-16T08:11:25Z 2012-09-16T08:11:25Z 2012-06 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | 35.232-2012.21 http://hdl.handle.net/11073/4075 |
| dc.language.none.fl_str_mv | en_US |
| dc.subject.none.fl_str_mv | Micellar drugs Acoustic power neural networks Folated micelles Ultrasonic drugs Doxorubicin Cancer Chemotherapy Chemical engineering |
| dc.title.none.fl_str_mv | Investigating and Modeling the Acoustic Release of Doxorubicin from Folate Targeted Micelles |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/doctoralThesis |
| description | A Master of Science thesis in Chemical Engineering by Laura Kherbeck entitled, "Investigating and Modeling the Acoustic Release of Doxorubicin from Folate-Targeted Micelles," submitted in June 2012. Thesis advisor is Dr. Ghaleb Al Husaini. Available are both soft and hard copies of the thesis. |
| format | doctoralThesis |
| id | aus_66eca4b408dd4bf78be956d75c300dab |
| identifier_str_mv | 35.232-2012.21 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/4075 |
| publishDate | 2012 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Investigating and Modeling the Acoustic Release of Doxorubicin from Folate Targeted MicellesKherbeck, LauraMicellar drugsAcoustic powerneural networksFolated micellesUltrasonic drugsDoxorubicinCancerChemotherapyChemical engineeringA Master of Science thesis in Chemical Engineering by Laura Kherbeck entitled, "Investigating and Modeling the Acoustic Release of Doxorubicin from Folate-Targeted Micelles," submitted in June 2012. Thesis advisor is Dr. Ghaleb Al Husaini. Available are both soft and hard copies of the thesis.To minimize the adverse side effects of conventional chemotherapy, a targeted micellar drug carrier was investigated that retains hydrophobic drugs in its core and then releases the drug via ultrasound. This thesis reports the synthesis of Pluronic P105 micelles with folic acid conjugated to their surface and measures the percent drug release from folated versus non-folated micelles at 70 kHz and different acoustic power densities. The encapsulated drug is Doxorubicin (Dox). Two physical models and their corresponding mathematical representation are then used to fit the data. The zero-order release with first-order re-encapsulation showed the best fit to the kinetic data of this targeted micellar system. Additionally, the acoustic activation power density and Gibbs free energy were calculated for folated and non-targeted micelles. An artificial neural network (ANN) model is also developed in an attempt to model the dynamic release of Dox from both folated and non-folated micelles and its subsequent re-encapsulation under various ultrasonic power densities at 70 kHz. The analysis shows that folated micelles exhibit a higher percentage of ultrasonic drug release than non-folated micelles. This could be because the folic acid ligand compromises the structural integrity of the micelle. Furthermore, the data suggest an important role of transient cavitation in drug release due to the presence of a power density threshold.College of EngineeringDepartment of Chemical EngineeringMaster of Science in Chemical Engineering (MSChE)Husseini, Ghaleb2012-09-16T08:11:25Z2012-09-16T08:11:25Z2012-06info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisapplication/pdf35.232-2012.21http://hdl.handle.net/11073/4075en_USoai:repository.aus.edu:11073/40752025-06-26T12:27:31Z |
| spellingShingle | Investigating and Modeling the Acoustic Release of Doxorubicin from Folate Targeted Micelles Kherbeck, Laura Micellar drugs Acoustic power neural networks Folated micelles Ultrasonic drugs Doxorubicin Cancer Chemotherapy Chemical engineering |
| status_str | publishedVersion |
| title | Investigating and Modeling the Acoustic Release of Doxorubicin from Folate Targeted Micelles |
| title_full | Investigating and Modeling the Acoustic Release of Doxorubicin from Folate Targeted Micelles |
| title_fullStr | Investigating and Modeling the Acoustic Release of Doxorubicin from Folate Targeted Micelles |
| title_full_unstemmed | Investigating and Modeling the Acoustic Release of Doxorubicin from Folate Targeted Micelles |
| title_short | Investigating and Modeling the Acoustic Release of Doxorubicin from Folate Targeted Micelles |
| title_sort | Investigating and Modeling the Acoustic Release of Doxorubicin from Folate Targeted Micelles |
| topic | Micellar drugs Acoustic power neural networks Folated micelles Ultrasonic drugs Doxorubicin Cancer Chemotherapy Chemical engineering |
| url | http://hdl.handle.net/11073/4075 |