Regulation of IB Function and NF-B Signaling: AEBP1 Is a Novel Proinflammatory Mediator in Macrophages
NF-B comprises a family of transcription factors that are critically involved in various inflammatory processes. In this paper, the role of NF-B in inflammation and atherosclerosis and the regulation of the NF-B signaling pathway are summarized. The structure, function, and regulation of the NF-B in...
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2010
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| Online Access: | http://hdl.handle.net/11073/25059 |
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| _version_ | 1864513442527838208 |
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| author | Majdalawieh, Amin |
| author2 | Ro, Hyo-Sung |
| author2_role | author |
| author_facet | Majdalawieh, Amin Ro, Hyo-Sung |
| author_role | author |
| dc.creator.none.fl_str_mv | Majdalawieh, Amin Ro, Hyo-Sung |
| dc.date.none.fl_str_mv | 2010 2022-10-31T09:39:55Z 2022-10-31T09:39:55Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Amin Majdalawieh, Hyo-Sung Ro, "Regulation of IB Function and NF-B Signaling: AEBP1 Is a Novel Proinflammatory Mediator in Macrophages", Mediators of Inflammation, vol. 2010, Article ID 823821, 27 pages, 2010. https://doi.org/10.1155/2010/823821 1466-1861 http://hdl.handle.net/11073/25059 10.1155/2010/823821 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | Hindawi |
| dc.relation.none.fl_str_mv | https://doi.org/10.1155/2010/823821 |
| dc.title.none.fl_str_mv | Regulation of IB Function and NF-B Signaling: AEBP1 Is a Novel Proinflammatory Mediator in Macrophages |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | NF-B comprises a family of transcription factors that are critically involved in various inflammatory processes. In this paper, the role of NF-B in inflammation and atherosclerosis and the regulation of the NF-B signaling pathway are summarized. The structure, function, and regulation of the NF-B inhibitors, IBα and IBβ , are reviewed. The regulation of NF-B activity by glucocorticoid receptor (GR) signaling and IBα sumoylation is also discussed. This paper focuses on the recently reported regulatory function that adipocyte enhancer-binding protein 1 (AEBP1) exerts on NF-B transcriptional activity in macrophages, in which AEBP1 manifests itself as a potent modulator of NF-B via physical interaction with IBα and a critical mediator of inflammation. Finally, we summarize the regulatory roles that recently identified IBα-interacting proteins play in NF-B signaling. Based on its proinflammatory roles in macrophages, AEBP1 is anticipated to serve as a therapeutic target towards the treatment of various inflammatory conditions and disorders. |
| format | article |
| id | aus_68ef8855cd68b908bfc5d50d31b85203 |
| identifier_str_mv | Amin Majdalawieh, Hyo-Sung Ro, "Regulation of IB Function and NF-B Signaling: AEBP1 Is a Novel Proinflammatory Mediator in Macrophages", Mediators of Inflammation, vol. 2010, Article ID 823821, 27 pages, 2010. https://doi.org/10.1155/2010/823821 1466-1861 10.1155/2010/823821 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/25059 |
| publishDate | 2010 |
| publisher.none.fl_str_mv | Hindawi |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Regulation of IB Function and NF-B Signaling: AEBP1 Is a Novel Proinflammatory Mediator in MacrophagesMajdalawieh, AminRo, Hyo-SungNF-B comprises a family of transcription factors that are critically involved in various inflammatory processes. In this paper, the role of NF-B in inflammation and atherosclerosis and the regulation of the NF-B signaling pathway are summarized. The structure, function, and regulation of the NF-B inhibitors, IBα and IBβ , are reviewed. The regulation of NF-B activity by glucocorticoid receptor (GR) signaling and IBα sumoylation is also discussed. This paper focuses on the recently reported regulatory function that adipocyte enhancer-binding protein 1 (AEBP1) exerts on NF-B transcriptional activity in macrophages, in which AEBP1 manifests itself as a potent modulator of NF-B via physical interaction with IBα and a critical mediator of inflammation. Finally, we summarize the regulatory roles that recently identified IBα-interacting proteins play in NF-B signaling. Based on its proinflammatory roles in macrophages, AEBP1 is anticipated to serve as a therapeutic target towards the treatment of various inflammatory conditions and disorders.Hindawi2022-10-31T09:39:55Z2022-10-31T09:39:55Z2010Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfAmin Majdalawieh, Hyo-Sung Ro, "Regulation of IB Function and NF-B Signaling: AEBP1 Is a Novel Proinflammatory Mediator in Macrophages", Mediators of Inflammation, vol. 2010, Article ID 823821, 27 pages, 2010. https://doi.org/10.1155/2010/8238211466-1861http://hdl.handle.net/11073/2505910.1155/2010/823821en_UShttps://doi.org/10.1155/2010/823821oai:repository.aus.edu:11073/250592024-08-22T12:00:08Z |
| spellingShingle | Regulation of IB Function and NF-B Signaling: AEBP1 Is a Novel Proinflammatory Mediator in Macrophages Majdalawieh, Amin |
| status_str | publishedVersion |
| title | Regulation of IB Function and NF-B Signaling: AEBP1 Is a Novel Proinflammatory Mediator in Macrophages |
| title_full | Regulation of IB Function and NF-B Signaling: AEBP1 Is a Novel Proinflammatory Mediator in Macrophages |
| title_fullStr | Regulation of IB Function and NF-B Signaling: AEBP1 Is a Novel Proinflammatory Mediator in Macrophages |
| title_full_unstemmed | Regulation of IB Function and NF-B Signaling: AEBP1 Is a Novel Proinflammatory Mediator in Macrophages |
| title_short | Regulation of IB Function and NF-B Signaling: AEBP1 Is a Novel Proinflammatory Mediator in Macrophages |
| title_sort | Regulation of IB Function and NF-B Signaling: AEBP1 Is a Novel Proinflammatory Mediator in Macrophages |
| url | http://hdl.handle.net/11073/25059 |