Investigating the Stability of eLiposomes at Elevated Temperatures
eLiposomes encapsulate a perfluorocarbon nanoemulsion droplet inside a liposome. Ultrasound is then used as a trigger mechanism to vaporize the perfluorocarbon, break the liposome, and release the desired drug to the tumor tissue. The purpose of this research is to show that eLiposomes synthesized u...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , |
| التنسيق: | article |
| منشور في: |
2014
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/11073/21303 |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513436596043776 |
|---|---|
| author | Husseini, Ghaleb |
| author2 | Pitt, William G. Javadi, Marjan |
| author2_role | author author |
| author_facet | Husseini, Ghaleb Pitt, William G. Javadi, Marjan |
| author_role | author |
| dc.creator.none.fl_str_mv | Husseini, Ghaleb Pitt, William G. Javadi, Marjan |
| dc.date.none.fl_str_mv | 2014 2021-01-28T08:15:52Z 2021-01-28T08:15:52Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Husseini GA, Pitt WG, Javadi M. Investigating the Stability of eLiposomes at Elevated Temperatures. Technology in Cancer Research & Treatment. August 2015:379-382. doi:10.1177/1533034614551480 1533-0346 http://hdl.handle.net/11073/21303 10.1177/1533034614551480 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | Sage Publishing |
| dc.relation.none.fl_str_mv | https://doi.org/10.1177/1533034614551480 |
| dc.subject.none.fl_str_mv | Nanodrug delivery Calcein Emulsion liposome eLiposome Temperature stability Perfluoropentane (PFC5) |
| dc.title.none.fl_str_mv | Investigating the Stability of eLiposomes at Elevated Temperatures |
| dc.type.none.fl_str_mv | Peer-Reviewed Postprint info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | eLiposomes encapsulate a perfluorocarbon nanoemulsion droplet inside a liposome. Ultrasound is then used as a trigger mechanism to vaporize the perfluorocarbon, break the liposome, and release the desired drug to the tumor tissue. The purpose of this research is to show that eLiposomes synthesized using perfluoropentane are stable above the normal boiling point of the perfluoropentane and at body temperature and thus has potential for use in vivo. Experiments involving the release of fluorescent calcein molecules were performed on eLiposomes to measure the release of calcein at various temperatures in the absence of ultrasound. Results showed that eLiposomes are stable at body temperatures and that as the temperature increases above 40°C, calcein release from these novel nanocarriers increases. |
| format | article |
| id | aus_6a006cc4f9fd508b83f66d5b03e92a17 |
| identifier_str_mv | Husseini GA, Pitt WG, Javadi M. Investigating the Stability of eLiposomes at Elevated Temperatures. Technology in Cancer Research & Treatment. August 2015:379-382. doi:10.1177/1533034614551480 1533-0346 10.1177/1533034614551480 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/21303 |
| publishDate | 2014 |
| publisher.none.fl_str_mv | Sage Publishing |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Investigating the Stability of eLiposomes at Elevated TemperaturesHusseini, GhalebPitt, William G.Javadi, MarjanNanodrug deliveryCalceinEmulsion liposomeeLiposomeTemperature stabilityPerfluoropentane (PFC5)eLiposomes encapsulate a perfluorocarbon nanoemulsion droplet inside a liposome. Ultrasound is then used as a trigger mechanism to vaporize the perfluorocarbon, break the liposome, and release the desired drug to the tumor tissue. The purpose of this research is to show that eLiposomes synthesized using perfluoropentane are stable above the normal boiling point of the perfluoropentane and at body temperature and thus has potential for use in vivo. Experiments involving the release of fluorescent calcein molecules were performed on eLiposomes to measure the release of calcein at various temperatures in the absence of ultrasound. Results showed that eLiposomes are stable at body temperatures and that as the temperature increases above 40°C, calcein release from these novel nanocarriers increases.Sage Publishing2021-01-28T08:15:52Z2021-01-28T08:15:52Z2014Peer-ReviewedPostprintinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfHusseini GA, Pitt WG, Javadi M. Investigating the Stability of eLiposomes at Elevated Temperatures. Technology in Cancer Research & Treatment. August 2015:379-382. doi:10.1177/15330346145514801533-0346http://hdl.handle.net/11073/2130310.1177/1533034614551480en_UShttps://doi.org/10.1177/1533034614551480oai:repository.aus.edu:11073/213032024-08-22T12:05:29Z |
| spellingShingle | Investigating the Stability of eLiposomes at Elevated Temperatures Husseini, Ghaleb Nanodrug delivery Calcein Emulsion liposome eLiposome Temperature stability Perfluoropentane (PFC5) |
| status_str | publishedVersion |
| title | Investigating the Stability of eLiposomes at Elevated Temperatures |
| title_full | Investigating the Stability of eLiposomes at Elevated Temperatures |
| title_fullStr | Investigating the Stability of eLiposomes at Elevated Temperatures |
| title_full_unstemmed | Investigating the Stability of eLiposomes at Elevated Temperatures |
| title_short | Investigating the Stability of eLiposomes at Elevated Temperatures |
| title_sort | Investigating the Stability of eLiposomes at Elevated Temperatures |
| topic | Nanodrug delivery Calcein Emulsion liposome eLiposome Temperature stability Perfluoropentane (PFC5) |
| url | http://hdl.handle.net/11073/21303 |