Biomedical Applications of Metal−Organic Frameworks for Disease Diagnosis and Drug Delivery: A Review
Metal−organic frameworks (MOFs) are a novel class of porous hybrid organic−inorganic materials that have attracted increasing attention over the past decade. MOFs can be used in chemical engineering, materials science, and chemistry applications. Recently, these structures have been thoroughly studi...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , |
| التنسيق: | article |
| منشور في: |
2021
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/11073/21589 |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513440292274176 |
|---|---|
| author | Al Sharabati, Miral Osama Yacoub |
| author2 | Sabouni, Rana Husseini, Ghaleb |
| author2_role | author author |
| author_facet | Al Sharabati, Miral Osama Yacoub Sabouni, Rana Husseini, Ghaleb |
| author_role | author |
| dc.creator.none.fl_str_mv | Al Sharabati, Miral Osama Yacoub Sabouni, Rana Husseini, Ghaleb |
| dc.date.none.fl_str_mv | 2021 2022-01-17T10:55:42Z 2022-01-17T10:55:42Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | : Al Sharabati, M.; Sabouni, R.; Husseini, G.A. Biomedical Applications of Metal−Organic Frameworks for Disease Diagnosis and Drug Delivery: A Review. Nanomaterials 2022, 12, 277. doi:10.3390/nano12020277 2079-4991 http://hdl.handle.net/11073/21589 10.3390/nano12020277 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | MDPI |
| dc.relation.none.fl_str_mv | https://doi.org/10.3390/nano12020277 |
| dc.subject.none.fl_str_mv | Metal-organic frameworks Disease diagnosis Drug delivery Theranostic agent |
| dc.title.none.fl_str_mv | Biomedical Applications of Metal−Organic Frameworks for Disease Diagnosis and Drug Delivery: A Review |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Metal−organic frameworks (MOFs) are a novel class of porous hybrid organic−inorganic materials that have attracted increasing attention over the past decade. MOFs can be used in chemical engineering, materials science, and chemistry applications. Recently, these structures have been thoroughly studied as promising platforms for biomedical applications. Due to their unique physical and chemical properties, they are regarded as promising candidates for disease diagnosis and drug delivery. Their well-defined structure, high porosity, tunable frameworks, wide range of pore shapes, ultrahigh surface area, relatively low toxicity, and easy chemical functionalization have made them the focus of extensive research. This review highlights the up-to-date progress of MOFs as potential platforms for disease diagnosis and drug delivery for a wide range of diseases such as cancer, diabetes, neurological disorders, and ocular diseases. A brief description of the synthesis methods of MOFs is first presented. Various examples of MOF-based sensors and DDSs are introduced for the different diseases. Finally, the challenges and perspectives are discussed to provide context for the future development of MOFs as efficient platforms for disease diagnosis and drug delivery systems. |
| format | article |
| id | aus_6d19cb625a7d7af748969149bd677b69 |
| identifier_str_mv | : Al Sharabati, M.; Sabouni, R.; Husseini, G.A. Biomedical Applications of Metal−Organic Frameworks for Disease Diagnosis and Drug Delivery: A Review. Nanomaterials 2022, 12, 277. doi:10.3390/nano12020277 2079-4991 10.3390/nano12020277 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/21589 |
| publishDate | 2021 |
| publisher.none.fl_str_mv | MDPI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Biomedical Applications of Metal−Organic Frameworks for Disease Diagnosis and Drug Delivery: A ReviewAl Sharabati, Miral Osama YacoubSabouni, RanaHusseini, GhalebMetal-organic frameworksDisease diagnosisDrug deliveryTheranostic agentMetal−organic frameworks (MOFs) are a novel class of porous hybrid organic−inorganic materials that have attracted increasing attention over the past decade. MOFs can be used in chemical engineering, materials science, and chemistry applications. Recently, these structures have been thoroughly studied as promising platforms for biomedical applications. Due to their unique physical and chemical properties, they are regarded as promising candidates for disease diagnosis and drug delivery. Their well-defined structure, high porosity, tunable frameworks, wide range of pore shapes, ultrahigh surface area, relatively low toxicity, and easy chemical functionalization have made them the focus of extensive research. This review highlights the up-to-date progress of MOFs as potential platforms for disease diagnosis and drug delivery for a wide range of diseases such as cancer, diabetes, neurological disorders, and ocular diseases. A brief description of the synthesis methods of MOFs is first presented. Various examples of MOF-based sensors and DDSs are introduced for the different diseases. Finally, the challenges and perspectives are discussed to provide context for the future development of MOFs as efficient platforms for disease diagnosis and drug delivery systems.American University of SharjahPatient's Friends Committee-SharjahAlJalila FoundationAl Qasimi FoundationTechnology Innovation Pioneer-Healthcare ProgramTakamul ProgramHamdan Bin Rashid Al Maktoum Award for Medical SciencesDana Gas Endowed Chair for Chemical EngineeringMDPI2022-01-17T10:55:42Z2022-01-17T10:55:42Z2021Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdf: Al Sharabati, M.; Sabouni, R.; Husseini, G.A. Biomedical Applications of Metal−Organic Frameworks for Disease Diagnosis and Drug Delivery: A Review. Nanomaterials 2022, 12, 277. doi:10.3390/nano120202772079-4991http://hdl.handle.net/11073/2158910.3390/nano12020277en_UShttps://doi.org/10.3390/nano12020277oai:repository.aus.edu:11073/215892024-08-22T12:04:30Z |
| spellingShingle | Biomedical Applications of Metal−Organic Frameworks for Disease Diagnosis and Drug Delivery: A Review Al Sharabati, Miral Osama Yacoub Metal-organic frameworks Disease diagnosis Drug delivery Theranostic agent |
| status_str | publishedVersion |
| title | Biomedical Applications of Metal−Organic Frameworks for Disease Diagnosis and Drug Delivery: A Review |
| title_full | Biomedical Applications of Metal−Organic Frameworks for Disease Diagnosis and Drug Delivery: A Review |
| title_fullStr | Biomedical Applications of Metal−Organic Frameworks for Disease Diagnosis and Drug Delivery: A Review |
| title_full_unstemmed | Biomedical Applications of Metal−Organic Frameworks for Disease Diagnosis and Drug Delivery: A Review |
| title_short | Biomedical Applications of Metal−Organic Frameworks for Disease Diagnosis and Drug Delivery: A Review |
| title_sort | Biomedical Applications of Metal−Organic Frameworks for Disease Diagnosis and Drug Delivery: A Review |
| topic | Metal-organic frameworks Disease diagnosis Drug delivery Theranostic agent |
| url | http://hdl.handle.net/11073/21589 |