Effects of mechano-electrical feedback on the onset of alternans: A computational study
Cardiac alternans is a heart rhythm instability that is associated with cardiac arrhythmias and may lead to sudden cardiac death. The onset of this instability, which is linked to period-doubling bifurcation and may be a route to chaos, is of particular interest. Mechano-electric feedback depicts th...
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2019
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| Online Access: | http://hdl.handle.net/11073/25364 |
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| _version_ | 1864513432491917312 |
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| author | Hazim, Azzam |
| author2 | Belhamadia, Youssef Dubljevic, Stevan |
| author2_role | author author |
| author_facet | Hazim, Azzam Belhamadia, Youssef Dubljevic, Stevan |
| author_role | author |
| dc.creator.none.fl_str_mv | Hazim, Azzam Belhamadia, Youssef Dubljevic, Stevan |
| dc.date.none.fl_str_mv | 2019-06 2023-09-25T04:51:53Z 2023-09-25T04:51:53Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Hazim, A., Belhamadia, Y., & Dubljevic, S. (2019). Effects of mechano-electrical feedback on the onset of alternans: A computational study. In Chaos: An Interdisciplinary Journal of Nonlinear Science (Vol. 29, Issue 6). AIP Publishing. https://doi.org/10.1063/1.5095778 1089-7682 http://hdl.handle.net/11073/25364 10.1063/1.5095778 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | AIP |
| dc.relation.none.fl_str_mv | https://doi.org/10.1063/1.5095778 |
| dc.subject.none.fl_str_mv | Linear stability analysis Electrical properties and parameters Continuum mechanics Electromechanics Mechanical stress Mooney-Rivlin solid Diseases and conditions Electrophysiology Action potential Cardiac dynamics |
| dc.title.none.fl_str_mv | Effects of mechano-electrical feedback on the onset of alternans: A computational study |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Cardiac alternans is a heart rhythm instability that is associated with cardiac arrhythmias and may lead to sudden cardiac death. The onset of this instability, which is linked to period-doubling bifurcation and may be a route to chaos, is of particular interest. Mechano-electric feedback depicts the effects of tissue deformation on cardiac excitation. The main effect of mechano-electric feedback is delivered via the so-called stretch-activated ion channels and is caused by stretch-activated currents. Mechano-electric feedback, which is believed to have proarrhythmic and antiarrhythmic effects on cardiac electrophysiology, affects the action potential duration in a manner dependent on cycle length, but the mechanisms by which this occurs remain to be elucidated. In this study, a biophysically detailed electromechanical model of cardiac tissue is employed to show how a stretch-activated current can affect the action potential duration at cellular and tissue levels, illustrating its effects on the onset of alternans. Also, using a two-dimensional iterated map that incorporates stretch-activated current effects, we apply linear stability analysis to study the stability of the bifurcation. We show that alternans bifurcation can be prevented depending on the strength of the stretch-activated current. |
| format | article |
| id | aus_738e72133782fc90784d9bb4fc6047e1 |
| identifier_str_mv | Hazim, A., Belhamadia, Y., & Dubljevic, S. (2019). Effects of mechano-electrical feedback on the onset of alternans: A computational study. In Chaos: An Interdisciplinary Journal of Nonlinear Science (Vol. 29, Issue 6). AIP Publishing. https://doi.org/10.1063/1.5095778 1089-7682 10.1063/1.5095778 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/25364 |
| publishDate | 2019 |
| publisher.none.fl_str_mv | AIP |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Effects of mechano-electrical feedback on the onset of alternans: A computational studyHazim, AzzamBelhamadia, YoussefDubljevic, StevanLinear stability analysisElectrical properties and parametersContinuum mechanicsElectromechanicsMechanical stressMooney-Rivlin solidDiseases and conditionsElectrophysiologyAction potentialCardiac dynamicsCardiac alternans is a heart rhythm instability that is associated with cardiac arrhythmias and may lead to sudden cardiac death. The onset of this instability, which is linked to period-doubling bifurcation and may be a route to chaos, is of particular interest. Mechano-electric feedback depicts the effects of tissue deformation on cardiac excitation. The main effect of mechano-electric feedback is delivered via the so-called stretch-activated ion channels and is caused by stretch-activated currents. Mechano-electric feedback, which is believed to have proarrhythmic and antiarrhythmic effects on cardiac electrophysiology, affects the action potential duration in a manner dependent on cycle length, but the mechanisms by which this occurs remain to be elucidated. In this study, a biophysically detailed electromechanical model of cardiac tissue is employed to show how a stretch-activated current can affect the action potential duration at cellular and tissue levels, illustrating its effects on the onset of alternans. Also, using a two-dimensional iterated map that incorporates stretch-activated current effects, we apply linear stability analysis to study the stability of the bifurcation. We show that alternans bifurcation can be prevented depending on the strength of the stretch-activated current.Natural Sciences and Engineering Research Council of Canada (NSERC)American University of SharjahAIP2023-09-25T04:51:53Z2023-09-25T04:51:53Z2019-06Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfHazim, A., Belhamadia, Y., & Dubljevic, S. (2019). Effects of mechano-electrical feedback on the onset of alternans: A computational study. In Chaos: An Interdisciplinary Journal of Nonlinear Science (Vol. 29, Issue 6). AIP Publishing. https://doi.org/10.1063/1.50957781089-7682http://hdl.handle.net/11073/2536410.1063/1.5095778en_UShttps://doi.org/10.1063/1.5095778oai:repository.aus.edu:11073/253642024-08-22T12:01:35Z |
| spellingShingle | Effects of mechano-electrical feedback on the onset of alternans: A computational study Hazim, Azzam Linear stability analysis Electrical properties and parameters Continuum mechanics Electromechanics Mechanical stress Mooney-Rivlin solid Diseases and conditions Electrophysiology Action potential Cardiac dynamics |
| status_str | publishedVersion |
| title | Effects of mechano-electrical feedback on the onset of alternans: A computational study |
| title_full | Effects of mechano-electrical feedback on the onset of alternans: A computational study |
| title_fullStr | Effects of mechano-electrical feedback on the onset of alternans: A computational study |
| title_full_unstemmed | Effects of mechano-electrical feedback on the onset of alternans: A computational study |
| title_short | Effects of mechano-electrical feedback on the onset of alternans: A computational study |
| title_sort | Effects of mechano-electrical feedback on the onset of alternans: A computational study |
| topic | Linear stability analysis Electrical properties and parameters Continuum mechanics Electromechanics Mechanical stress Mooney-Rivlin solid Diseases and conditions Electrophysiology Action potential Cardiac dynamics |
| url | http://hdl.handle.net/11073/25364 |