Anti-cancer Drug Delivery Using Metal Organic Frameworks (MOFs)
Cancer is the uncontrolled growth of cells in the body and is considered as one of the major causes of death globally. There are several cytotoxic chemotherapeutic agents used to treat cancer including methotrexate, 5-fluorouracil, cisplatin, tamoxifen, doxorubicin and others. Although billions of d...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , |
| التنسيق: | article |
| منشور في: |
2017
|
| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/11073/21313 |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513444653301760 |
|---|---|
| author | Ibrahim, Mihad |
| author2 | Sabouni, Rana Husseini, Ghaleb |
| author2_role | author author |
| author_facet | Ibrahim, Mihad Sabouni, Rana Husseini, Ghaleb |
| author_role | author |
| dc.creator.none.fl_str_mv | Ibrahim, Mihad Sabouni, Rana Husseini, Ghaleb |
| dc.date.none.fl_str_mv | 2017 2021-02-02T08:46:01Z 2021-02-02T08:46:01Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Mihad Ibrahim, Rana Sabouni and Ghaleb A. Husseini, “Anti-cancer Drug Delivery Using Metal Organic Frameworks (MOFs)”, Current Medicinal Chemistry (2017) 24: 193. https://doi.org/10.2174/0929867323666160926151216 0929-8673 http://hdl.handle.net/11073/21313 10.2174/0929867323666160926151216 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | Bentham Science Publishers |
| dc.relation.none.fl_str_mv | https://doi.org/10.2174/0929867323666160926151216 |
| dc.subject.none.fl_str_mv | Cancer Chemotherapy Metal-Organic Frameworks (MOFs) Loading Release Cytotoxicity |
| dc.title.none.fl_str_mv | Anti-cancer Drug Delivery Using Metal Organic Frameworks (MOFs) |
| dc.type.none.fl_str_mv | Peer-Reviewed Postprint info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Cancer is the uncontrolled growth of cells in the body and is considered as one of the major causes of death globally. There are several cytotoxic chemotherapeutic agents used to treat cancer including methotrexate, 5-fluorouracil, cisplatin, tamoxifen, doxorubicin and others. Although billions of dollars have been spent on cancer research to develop these chemotherapies, it still remains a major illness for mankind partly due to the shortcomings of these therapies. These shortcomings include low targeting specificity, severe side effects (due to high doses) and poor pharmacokinetics. To avoid these drawbacks, anti-cancer drug delivery systems have been developed recently using nanocarriers including liposomes, micelles, polyelectrolyte capsules and others. One of the recent class of nanoparticles investigated for chemotherapeutic use are metal organic frameworks (MOFs) which are hybrid polymers that consist of metal ions or clusters and organic ligands. MOFs are used in many applications including gas/vapor separation, gas storage, catalysis, luminescent materials, and biomedical imaging. These structures have additional features that promote their use as drug carriers in the biomedical field. First, they are nontoxic, biodegradable and have the ability to carry high loadings of the anti-neoplastic agent due to their porous nature. Also, they have well-defined crystalline structures that can be characterized by different analytical techniques and their sizes are suitable to control their in vivo drug release. |
| format | article |
| id | aus_75d1e6389965b958207e6bfdfacc67dc |
| identifier_str_mv | Mihad Ibrahim, Rana Sabouni and Ghaleb A. Husseini, “Anti-cancer Drug Delivery Using Metal Organic Frameworks (MOFs)”, Current Medicinal Chemistry (2017) 24: 193. https://doi.org/10.2174/0929867323666160926151216 0929-8673 10.2174/0929867323666160926151216 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/21313 |
| publishDate | 2017 |
| publisher.none.fl_str_mv | Bentham Science Publishers |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Anti-cancer Drug Delivery Using Metal Organic Frameworks (MOFs)Ibrahim, MihadSabouni, RanaHusseini, GhalebCancerChemotherapyMetal-Organic Frameworks (MOFs)LoadingReleaseCytotoxicityCancer is the uncontrolled growth of cells in the body and is considered as one of the major causes of death globally. There are several cytotoxic chemotherapeutic agents used to treat cancer including methotrexate, 5-fluorouracil, cisplatin, tamoxifen, doxorubicin and others. Although billions of dollars have been spent on cancer research to develop these chemotherapies, it still remains a major illness for mankind partly due to the shortcomings of these therapies. These shortcomings include low targeting specificity, severe side effects (due to high doses) and poor pharmacokinetics. To avoid these drawbacks, anti-cancer drug delivery systems have been developed recently using nanocarriers including liposomes, micelles, polyelectrolyte capsules and others. One of the recent class of nanoparticles investigated for chemotherapeutic use are metal organic frameworks (MOFs) which are hybrid polymers that consist of metal ions or clusters and organic ligands. MOFs are used in many applications including gas/vapor separation, gas storage, catalysis, luminescent materials, and biomedical imaging. These structures have additional features that promote their use as drug carriers in the biomedical field. First, they are nontoxic, biodegradable and have the ability to carry high loadings of the anti-neoplastic agent due to their porous nature. Also, they have well-defined crystalline structures that can be characterized by different analytical techniques and their sizes are suitable to control their in vivo drug release.Bentham Science Publishers2021-02-02T08:46:01Z2021-02-02T08:46:01Z2017Peer-ReviewedPostprintinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfMihad Ibrahim, Rana Sabouni and Ghaleb A. Husseini, “Anti-cancer Drug Delivery Using Metal Organic Frameworks (MOFs)”, Current Medicinal Chemistry (2017) 24: 193. https://doi.org/10.2174/09298673236661609261512160929-8673http://hdl.handle.net/11073/2131310.2174/0929867323666160926151216en_UShttps://doi.org/10.2174/0929867323666160926151216oai:repository.aus.edu:11073/213132024-08-22T12:06:25Z |
| spellingShingle | Anti-cancer Drug Delivery Using Metal Organic Frameworks (MOFs) Ibrahim, Mihad Cancer Chemotherapy Metal-Organic Frameworks (MOFs) Loading Release Cytotoxicity |
| status_str | publishedVersion |
| title | Anti-cancer Drug Delivery Using Metal Organic Frameworks (MOFs) |
| title_full | Anti-cancer Drug Delivery Using Metal Organic Frameworks (MOFs) |
| title_fullStr | Anti-cancer Drug Delivery Using Metal Organic Frameworks (MOFs) |
| title_full_unstemmed | Anti-cancer Drug Delivery Using Metal Organic Frameworks (MOFs) |
| title_short | Anti-cancer Drug Delivery Using Metal Organic Frameworks (MOFs) |
| title_sort | Anti-cancer Drug Delivery Using Metal Organic Frameworks (MOFs) |
| topic | Cancer Chemotherapy Metal-Organic Frameworks (MOFs) Loading Release Cytotoxicity |
| url | http://hdl.handle.net/11073/21313 |