Review of Gold Nanoparticles: Synthesis, Properties, Shapes, Cellular Uptake, Targeting, Release Mechanisms and Applications in Drug Delivery and Therapy
The remarkable versatility of gold nanoparticles (AuNPs) makes them innovative agents across various fields, including drug delivery, biosensing, catalysis, bioimaging, and vaccine development. This paper provides a detailed review of the important role of AuNPs in drug delivery and therapeutics. We...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , |
| التنسيق: | article |
| منشور في: |
2024
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://hdl.handle.net/11073/25714 |
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| _version_ | 1864513435782348800 |
|---|---|
| author | Georgeous, Joel |
| author2 | AlSawaftah, Nour Abuwatfa, Waad Husseini, Ghaleb |
| author2_role | author author author |
| author_facet | Georgeous, Joel AlSawaftah, Nour Abuwatfa, Waad Husseini, Ghaleb |
| author_role | author |
| dc.creator.none.fl_str_mv | Georgeous, Joel AlSawaftah, Nour Abuwatfa, Waad Husseini, Ghaleb |
| dc.date.none.fl_str_mv | 2024-11-14T07:08:37Z 2024-11-14T07:08:37Z 2024-10-16 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Georgeous, J., AlSawaftah, N., Abuwatfa, W. H., & Husseini, G. A. (2024). Review of Gold Nanoparticles: Synthesis, Properties, Shapes, Cellular Uptake, Targeting, Release Mechanisms and Applications in Drug Delivery and Therapy. In Pharmaceutics (Vol. 16, Issue 10, p. 1332). MDPI AG. https://doi.org/10.3390/pharmaceutics16101332 1999-4923 https://hdl.handle.net/11073/25714 10.3390/pharmaceutics16101332 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | MDPI |
| dc.relation.none.fl_str_mv | https://doi.org/10.3390/pharmaceutics16101332 |
| dc.rights.none.fl_str_mv | Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
| dc.subject.none.fl_str_mv | Gold nanoparticles Drug delivery Nanotechnology Cancer treatment Targeted delivery |
| dc.title.none.fl_str_mv | Review of Gold Nanoparticles: Synthesis, Properties, Shapes, Cellular Uptake, Targeting, Release Mechanisms and Applications in Drug Delivery and Therapy |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | The remarkable versatility of gold nanoparticles (AuNPs) makes them innovative agents across various fields, including drug delivery, biosensing, catalysis, bioimaging, and vaccine development. This paper provides a detailed review of the important role of AuNPs in drug delivery and therapeutics. We begin by exploring traditional drug delivery systems (DDS), highlighting the role of nanoparticles in revolutionizing drug delivery techniques. We then describe the unique and intriguing properties of AuNPs that make them exceptional for drug delivery. Their shapes, functionalization, drug-loading bonds, targeting mechanisms, release mechanisms, therapeutic effects, and cellular uptake methods are discussed, along with relevant examples from the literature. Lastly, we present the drug delivery applications of AuNPs across various medical domains, including cancer, cardiovascular diseases, ocular diseases, and diabetes, with a focus on in vitro and in vivo cancer research. |
| format | article |
| id | aus_7795115b47684e0e5edf3cf2c8377d52 |
| identifier_str_mv | Georgeous, J., AlSawaftah, N., Abuwatfa, W. H., & Husseini, G. A. (2024). Review of Gold Nanoparticles: Synthesis, Properties, Shapes, Cellular Uptake, Targeting, Release Mechanisms and Applications in Drug Delivery and Therapy. In Pharmaceutics (Vol. 16, Issue 10, p. 1332). MDPI AG. https://doi.org/10.3390/pharmaceutics16101332 1999-4923 10.3390/pharmaceutics16101332 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/25714 |
| publishDate | 2024 |
| publisher.none.fl_str_mv | MDPI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
| spelling | Review of Gold Nanoparticles: Synthesis, Properties, Shapes, Cellular Uptake, Targeting, Release Mechanisms and Applications in Drug Delivery and TherapyGeorgeous, JoelAlSawaftah, NourAbuwatfa, WaadHusseini, GhalebGold nanoparticlesDrug deliveryNanotechnologyCancer treatmentTargeted deliveryThe remarkable versatility of gold nanoparticles (AuNPs) makes them innovative agents across various fields, including drug delivery, biosensing, catalysis, bioimaging, and vaccine development. This paper provides a detailed review of the important role of AuNPs in drug delivery and therapeutics. We begin by exploring traditional drug delivery systems (DDS), highlighting the role of nanoparticles in revolutionizing drug delivery techniques. We then describe the unique and intriguing properties of AuNPs that make them exceptional for drug delivery. Their shapes, functionalization, drug-loading bonds, targeting mechanisms, release mechanisms, therapeutic effects, and cellular uptake methods are discussed, along with relevant examples from the literature. Lastly, we present the drug delivery applications of AuNPs across various medical domains, including cancer, cardiovascular diseases, ocular diseases, and diabetes, with a focus on in vitro and in vivo cancer research.American University of SharjahAl-Jalila FoundationAl Qasimi FoundationPatient’s Friends Committee-SharjahBiosciences and Bioengineering Research InstituteGCC Co-Fund ProgramTakamul programTechnology Innovation Pioneer (TIP) Healthcare AwardsSheikh Hamdan Award for Medical SciencesFriends of Cancer Patients (FoCP)Dana Gas Endowed Chair for Chemical EngineeringMDPI2024-11-14T07:08:37Z2024-11-14T07:08:37Z2024-10-16Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfGeorgeous, J., AlSawaftah, N., Abuwatfa, W. H., & Husseini, G. A. (2024). Review of Gold Nanoparticles: Synthesis, Properties, Shapes, Cellular Uptake, Targeting, Release Mechanisms and Applications in Drug Delivery and Therapy. In Pharmaceutics (Vol. 16, Issue 10, p. 1332). MDPI AG. https://doi.org/10.3390/pharmaceutics161013321999-4923https://hdl.handle.net/11073/2571410.3390/pharmaceutics16101332en_UShttps://doi.org/10.3390/pharmaceutics16101332Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/oai:repository.aus.edu:11073/257142024-11-14T14:18:47Z |
| spellingShingle | Review of Gold Nanoparticles: Synthesis, Properties, Shapes, Cellular Uptake, Targeting, Release Mechanisms and Applications in Drug Delivery and Therapy Georgeous, Joel Gold nanoparticles Drug delivery Nanotechnology Cancer treatment Targeted delivery |
| status_str | publishedVersion |
| title | Review of Gold Nanoparticles: Synthesis, Properties, Shapes, Cellular Uptake, Targeting, Release Mechanisms and Applications in Drug Delivery and Therapy |
| title_full | Review of Gold Nanoparticles: Synthesis, Properties, Shapes, Cellular Uptake, Targeting, Release Mechanisms and Applications in Drug Delivery and Therapy |
| title_fullStr | Review of Gold Nanoparticles: Synthesis, Properties, Shapes, Cellular Uptake, Targeting, Release Mechanisms and Applications in Drug Delivery and Therapy |
| title_full_unstemmed | Review of Gold Nanoparticles: Synthesis, Properties, Shapes, Cellular Uptake, Targeting, Release Mechanisms and Applications in Drug Delivery and Therapy |
| title_short | Review of Gold Nanoparticles: Synthesis, Properties, Shapes, Cellular Uptake, Targeting, Release Mechanisms and Applications in Drug Delivery and Therapy |
| title_sort | Review of Gold Nanoparticles: Synthesis, Properties, Shapes, Cellular Uptake, Targeting, Release Mechanisms and Applications in Drug Delivery and Therapy |
| topic | Gold nanoparticles Drug delivery Nanotechnology Cancer treatment Targeted delivery |
| url | https://hdl.handle.net/11073/25714 |