Liposomes for the Treatment of Brain Cancer — A Review
Due to their biocompatibility, non-toxicity, and surface-conjugation capabilities, liposomes are effective nanocarriers that can encapsulate chemotherapeutic drugs and facilitate targeted delivery across the blood–brain barrier (BBB). Additionally, strategies have been explored to synthesize liposom...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , |
| التنسيق: | article |
| منشور في: |
2023
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/11073/25297 |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513443267084288 |
|---|---|
| author | Raju, Richu |
| author2 | Abuwatfa, Waad Hussein Pitt, William G. Husseini, Ghaleb |
| author2_role | author author author |
| author_facet | Raju, Richu Abuwatfa, Waad Hussein Pitt, William G. Husseini, Ghaleb |
| author_role | author |
| dc.creator.none.fl_str_mv | Raju, Richu Abuwatfa, Waad Hussein Pitt, William G. Husseini, Ghaleb |
| dc.date.none.fl_str_mv | 2023-08-25T07:07:27Z 2023-08-25T07:07:27Z 2023-06-25 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Raju, R., Abuwatfa, W. H., Pitt, W. G., & Husseini, G. A. (2023). Liposomes for the Treatment of Brain Cancer—A Review. Pharmaceuticals, 16(8), 1056. MDPI. doi:10.3390/ph16081056 1424-8247 http://hdl.handle.net/11073/25297 10.3390/ph16081056 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | MDPI |
| dc.relation.none.fl_str_mv | https://doi.org/10.3390/ph16081056 |
| dc.subject.none.fl_str_mv | Liposomes Nanocarriers Brain Targeted drug delivery |
| dc.title.none.fl_str_mv | Liposomes for the Treatment of Brain Cancer — A Review |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Due to their biocompatibility, non-toxicity, and surface-conjugation capabilities, liposomes are effective nanocarriers that can encapsulate chemotherapeutic drugs and facilitate targeted delivery across the blood–brain barrier (BBB). Additionally, strategies have been explored to synthesize liposomes that respond to internal and/or external stimuli to release their payload controllably. Although research into liposomes for brain cancer treatment is still in its infancy, these systems have great potential to fundamentally change the drug delivery landscape. This review paper attempts to consolidate relevant literature regarding the delivery to the brain using nanocarriers, particularly liposomes. The paper first briefly explains conventional treatment modalities for cancer, followed by describing the blood–brain barrier and ways, challenges, and techniques involved in transporting drugs across the BBB. Various nanocarrier systems are introduced, with attention to liposomes, due to their ability to circumvent the challenges imposed by the BBB. Relevant studies involving liposomal systems researched to treat brain tumors are reviewed in vitro, in vivo, and clinical studies. Finally, the challenges associated with the use of liposomes to treat brain tumors and how they can be addressed are presented. |
| format | article |
| id | aus_7d2ef93d486789952b5f6dc0ca767730 |
| identifier_str_mv | Raju, R., Abuwatfa, W. H., Pitt, W. G., & Husseini, G. A. (2023). Liposomes for the Treatment of Brain Cancer—A Review. Pharmaceuticals, 16(8), 1056. MDPI. doi:10.3390/ph16081056 1424-8247 10.3390/ph16081056 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/25297 |
| publishDate | 2023 |
| publisher.none.fl_str_mv | MDPI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Liposomes for the Treatment of Brain Cancer — A ReviewRaju, RichuAbuwatfa, Waad HusseinPitt, William G.Husseini, GhalebLiposomesNanocarriersBrainTargeted drug deliveryDue to their biocompatibility, non-toxicity, and surface-conjugation capabilities, liposomes are effective nanocarriers that can encapsulate chemotherapeutic drugs and facilitate targeted delivery across the blood–brain barrier (BBB). Additionally, strategies have been explored to synthesize liposomes that respond to internal and/or external stimuli to release their payload controllably. Although research into liposomes for brain cancer treatment is still in its infancy, these systems have great potential to fundamentally change the drug delivery landscape. This review paper attempts to consolidate relevant literature regarding the delivery to the brain using nanocarriers, particularly liposomes. The paper first briefly explains conventional treatment modalities for cancer, followed by describing the blood–brain barrier and ways, challenges, and techniques involved in transporting drugs across the BBB. Various nanocarrier systems are introduced, with attention to liposomes, due to their ability to circumvent the challenges imposed by the BBB. Relevant studies involving liposomal systems researched to treat brain tumors are reviewed in vitro, in vivo, and clinical studies. Finally, the challenges associated with the use of liposomes to treat brain tumors and how they can be addressed are presented.American University of SharjahAl-Jalila FoundationPatient's Friends Committee of SharjahBiosciences and Bioengineering Research InstituteGCC Co-Fund ProgramTakamul programTechnology Innovation Pioneer (TIP) Healthcare AwardsSheikh Hamdan Award for Medical SciencesFriends of Cancer Patients (FoCP)Dana Gas Endowed Chair for Chemical EngineeringMDPI2023-08-25T07:07:27Z2023-08-25T07:07:27Z2023-06-25Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfRaju, R., Abuwatfa, W. H., Pitt, W. G., & Husseini, G. A. (2023). Liposomes for the Treatment of Brain Cancer—A Review. Pharmaceuticals, 16(8), 1056. MDPI. doi:10.3390/ph160810561424-8247http://hdl.handle.net/11073/2529710.3390/ph16081056en_UShttps://doi.org/10.3390/ph16081056oai:repository.aus.edu:11073/252972024-08-22T12:05:45Z |
| spellingShingle | Liposomes for the Treatment of Brain Cancer — A Review Raju, Richu Liposomes Nanocarriers Brain Targeted drug delivery |
| status_str | publishedVersion |
| title | Liposomes for the Treatment of Brain Cancer — A Review |
| title_full | Liposomes for the Treatment of Brain Cancer — A Review |
| title_fullStr | Liposomes for the Treatment of Brain Cancer — A Review |
| title_full_unstemmed | Liposomes for the Treatment of Brain Cancer — A Review |
| title_short | Liposomes for the Treatment of Brain Cancer — A Review |
| title_sort | Liposomes for the Treatment of Brain Cancer — A Review |
| topic | Liposomes Nanocarriers Brain Targeted drug delivery |
| url | http://hdl.handle.net/11073/25297 |