Investigating the acoustic release of doxorubicin from targeted micelles
The main problem associated with the administration of anti-cancer medication is that the drug is delivered throughout the body causing undesirable side effects. Therefore, it is important to synthesize drug carriers capable of minimizing the adverse side effects of chemotherapy by preferentially ta...
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| مؤلفون آخرون: | , , , , |
| التنسيق: | article |
| منشور في: |
2013
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/11073/21299 |
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| _version_ | 1864513432462557184 |
|---|---|
| author | Husseini, Ghaleb |
| author2 | Velluto, Diana Kherbeck, Laura Pitt, William G. Hubbell, Jeffrey A. Christensen, Douglas A. |
| author2_role | author author author author author |
| author_facet | Husseini, Ghaleb Velluto, Diana Kherbeck, Laura Pitt, William G. Hubbell, Jeffrey A. Christensen, Douglas A. |
| author_role | author |
| dc.creator.none.fl_str_mv | Husseini, Ghaleb Velluto, Diana Kherbeck, Laura Pitt, William G. Hubbell, Jeffrey A. Christensen, Douglas A. |
| dc.date.none.fl_str_mv | 2013 2021-01-28T06:44:22Z 2021-01-28T06:44:22Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Ghaleb A. Husseini, Diana Velluto, Laura Kherbeck, William G. Pitt, Jeffrey A. Hubbell, Douglas A. Christensen, Investigating the acoustic release of doxorubicin from targeted micelles, Colloids and Surfaces B: Biointerfaces, Volume 101, 2013, Pages 153-155, ISSN 0927-7765, https://doi.org/10.1016/j.colsurfb.2012.05.025. 0927-7765 http://hdl.handle.net/11073/21299 10.1016/j.colsurfb.2012.05.025 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.relation.none.fl_str_mv | https://doi.org/10.1016/j.colsurfb.2012.05.025 |
| dc.subject.none.fl_str_mv | Folic acid Doxorubicin 70-kHz ultrasound Pluronic P105 Polymeric micelles Cavitation Drug release |
| dc.title.none.fl_str_mv | Investigating the acoustic release of doxorubicin from targeted micelles |
| dc.type.none.fl_str_mv | Peer-Reviewed Postprint info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | The main problem associated with the administration of anti-cancer medication is that the drug is delivered throughout the body causing undesirable side effects. Therefore, it is important to synthesize drug carriers capable of minimizing the adverse side effects of chemotherapy by preferentially targeting tumor cells both actively (e.g. a folate receptor) and using external stimulus (e.g. ultrasound). In this paper, we report the synthesis of Pluronic P105 micelles with a folate targeting moiety (with a yield of 48%) containing doxorubicin (Dox). We applied low frequency ultrasound as an external stimulus and measured the amount of release of Dox from these folated micelles. The results showed that the percent drug release increases as the power intensity of ultrasound increases. The maximum amount of release (14%) was measured at 5.4 W/cm². A power density threshold at approximately 0.55 W/cm² exists below which no statistically significant release was observed. This lower threshold suggests that cavitation plays an important role in triggering drug release from targeted micelles. |
| format | article |
| id | aus_7f8f58f355bcea0b10a978de868020dd |
| identifier_str_mv | Ghaleb A. Husseini, Diana Velluto, Laura Kherbeck, William G. Pitt, Jeffrey A. Hubbell, Douglas A. Christensen, Investigating the acoustic release of doxorubicin from targeted micelles, Colloids and Surfaces B: Biointerfaces, Volume 101, 2013, Pages 153-155, ISSN 0927-7765, https://doi.org/10.1016/j.colsurfb.2012.05.025. 0927-7765 10.1016/j.colsurfb.2012.05.025 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/21299 |
| publishDate | 2013 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Investigating the acoustic release of doxorubicin from targeted micellesHusseini, GhalebVelluto, DianaKherbeck, LauraPitt, William G.Hubbell, Jeffrey A.Christensen, Douglas A.Folic acidDoxorubicin70-kHz ultrasoundPluronic P105Polymeric micellesCavitationDrug releaseThe main problem associated with the administration of anti-cancer medication is that the drug is delivered throughout the body causing undesirable side effects. Therefore, it is important to synthesize drug carriers capable of minimizing the adverse side effects of chemotherapy by preferentially targeting tumor cells both actively (e.g. a folate receptor) and using external stimulus (e.g. ultrasound). In this paper, we report the synthesis of Pluronic P105 micelles with a folate targeting moiety (with a yield of 48%) containing doxorubicin (Dox). We applied low frequency ultrasound as an external stimulus and measured the amount of release of Dox from these folated micelles. The results showed that the percent drug release increases as the power intensity of ultrasound increases. The maximum amount of release (14%) was measured at 5.4 W/cm². A power density threshold at approximately 0.55 W/cm² exists below which no statistically significant release was observed. This lower threshold suggests that cavitation plays an important role in triggering drug release from targeted micelles.Elsevier2021-01-28T06:44:22Z2021-01-28T06:44:22Z2013Peer-ReviewedPostprintinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfGhaleb A. Husseini, Diana Velluto, Laura Kherbeck, William G. Pitt, Jeffrey A. Hubbell, Douglas A. Christensen, Investigating the acoustic release of doxorubicin from targeted micelles, Colloids and Surfaces B: Biointerfaces, Volume 101, 2013, Pages 153-155, ISSN 0927-7765, https://doi.org/10.1016/j.colsurfb.2012.05.025.0927-7765http://hdl.handle.net/11073/2129910.1016/j.colsurfb.2012.05.025en_UShttps://doi.org/10.1016/j.colsurfb.2012.05.025oai:repository.aus.edu:11073/212992024-08-22T12:04:26Z |
| spellingShingle | Investigating the acoustic release of doxorubicin from targeted micelles Husseini, Ghaleb Folic acid Doxorubicin 70-kHz ultrasound Pluronic P105 Polymeric micelles Cavitation Drug release |
| status_str | publishedVersion |
| title | Investigating the acoustic release of doxorubicin from targeted micelles |
| title_full | Investigating the acoustic release of doxorubicin from targeted micelles |
| title_fullStr | Investigating the acoustic release of doxorubicin from targeted micelles |
| title_full_unstemmed | Investigating the acoustic release of doxorubicin from targeted micelles |
| title_short | Investigating the acoustic release of doxorubicin from targeted micelles |
| title_sort | Investigating the acoustic release of doxorubicin from targeted micelles |
| topic | Folic acid Doxorubicin 70-kHz ultrasound Pluronic P105 Polymeric micelles Cavitation Drug release |
| url | http://hdl.handle.net/11073/21299 |