Modeling of Drug Release Kinetics from Stimuli- Responsive Micelles and Liposomes: A review
Nanocarriers such as micelles and liposomes were developed to enhance the delivery of therapeutic drugs to tumors. Internal or external stimuli can be applied to achieve spatiotemporal controlled release from these carriers. This will result in enhancing the therapeutic efficacy of anti-neoplastic d...
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2021
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| Online Access: | http://hdl.handle.net/11073/21533 |
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| _version_ | 1864513434856456192 |
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| author | AlSawaftah, Nour Majdi |
| author2 | Paul, Vinod Awad, Nahid S. Husseini, Ghaleb |
| author2_role | author author author |
| author_facet | AlSawaftah, Nour Majdi Paul, Vinod Awad, Nahid S. Husseini, Ghaleb |
| author_role | author |
| dc.creator.none.fl_str_mv | AlSawaftah, Nour Majdi Paul, Vinod Awad, Nahid S. Husseini, Ghaleb |
| dc.date.none.fl_str_mv | 2021-09-13T12:43:48Z 2021-09-13T12:43:48Z 2021 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Sawaftah, N. A., Paul, V., Awad, N., & Husseini, G. A. (2021). Modeling of Anti-cancer Drug Release Kinetics from Liposomes and Micelles: A review. IEEE Transactions on NanoBioscience, 1–1. https://doi.org/10.1109/tnb.2021.3097909 1558-2639 http://hdl.handle.net/11073/21533 10.1109/tnb.2021.3097909 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | IEEE |
| dc.relation.none.fl_str_mv | https://doi.org/10.1109/TNB.2021.3097909 |
| dc.subject.none.fl_str_mv | Micelles Liposomes Drug release kinetics Mathematical modeling |
| dc.title.none.fl_str_mv | Modeling of Drug Release Kinetics from Stimuli- Responsive Micelles and Liposomes: A review |
| dc.type.none.fl_str_mv | Peer-Reviewed Postprint info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Nanocarriers such as micelles and liposomes were developed to enhance the delivery of therapeutic drugs to tumors. Internal or external stimuli can be applied to achieve spatiotemporal controlled release from these carriers. This will result in enhancing the therapeutic efficacy of anti-neoplastic drugs while reducing their toxicity. Mathematical modeling is used to simulate drug release from nanocarriers; this will facilitate and optimize the development and design of desirable nanocarriers in a systematic manner, rather than the existing trial-and-error approach. This review summarizes nine mathematical models often used to simulate drug release from drug delivery systems and reviews studies that employed these models to simulate drug release from conventional micelles and liposomes, as well as temperature-, pH-, and ultrasound-triggered micelles and liposomes. |
| format | article |
| id | aus_8b0a0e2d3c44fadd3778268620a97aa8 |
| identifier_str_mv | Sawaftah, N. A., Paul, V., Awad, N., & Husseini, G. A. (2021). Modeling of Anti-cancer Drug Release Kinetics from Liposomes and Micelles: A review. IEEE Transactions on NanoBioscience, 1–1. https://doi.org/10.1109/tnb.2021.3097909 1558-2639 10.1109/tnb.2021.3097909 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/21533 |
| publishDate | 2021 |
| publisher.none.fl_str_mv | IEEE |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Modeling of Drug Release Kinetics from Stimuli- Responsive Micelles and Liposomes: A reviewAlSawaftah, Nour MajdiPaul, VinodAwad, Nahid S.Husseini, GhalebMicellesLiposomesDrug release kineticsMathematical modelingNanocarriers such as micelles and liposomes were developed to enhance the delivery of therapeutic drugs to tumors. Internal or external stimuli can be applied to achieve spatiotemporal controlled release from these carriers. This will result in enhancing the therapeutic efficacy of anti-neoplastic drugs while reducing their toxicity. Mathematical modeling is used to simulate drug release from nanocarriers; this will facilitate and optimize the development and design of desirable nanocarriers in a systematic manner, rather than the existing trial-and-error approach. This review summarizes nine mathematical models often used to simulate drug release from drug delivery systems and reviews studies that employed these models to simulate drug release from conventional micelles and liposomes, as well as temperature-, pH-, and ultrasound-triggered micelles and liposomes.American University of SharjahAl-Jalila FoundationAl Qasimi FoundationPatient's Friends Committee-SharjahBiosciences and Bioengineering Research InstituteTakamul programTechnology Innovation Pioneer (TIP) Healthcare AwardsDana Gas Endowed Chair for Chemical EngineeringIEEE2021-09-13T12:43:48Z2021-09-13T12:43:48Z2021Peer-ReviewedPostprintinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfSawaftah, N. A., Paul, V., Awad, N., & Husseini, G. A. (2021). Modeling of Anti-cancer Drug Release Kinetics from Liposomes and Micelles: A review. IEEE Transactions on NanoBioscience, 1–1. https://doi.org/10.1109/tnb.2021.30979091558-2639http://hdl.handle.net/11073/2153310.1109/tnb.2021.3097909en_UShttps://doi.org/10.1109/TNB.2021.3097909oai:repository.aus.edu:11073/215332024-08-22T12:06:15Z |
| spellingShingle | Modeling of Drug Release Kinetics from Stimuli- Responsive Micelles and Liposomes: A review AlSawaftah, Nour Majdi Micelles Liposomes Drug release kinetics Mathematical modeling |
| status_str | publishedVersion |
| title | Modeling of Drug Release Kinetics from Stimuli- Responsive Micelles and Liposomes: A review |
| title_full | Modeling of Drug Release Kinetics from Stimuli- Responsive Micelles and Liposomes: A review |
| title_fullStr | Modeling of Drug Release Kinetics from Stimuli- Responsive Micelles and Liposomes: A review |
| title_full_unstemmed | Modeling of Drug Release Kinetics from Stimuli- Responsive Micelles and Liposomes: A review |
| title_short | Modeling of Drug Release Kinetics from Stimuli- Responsive Micelles and Liposomes: A review |
| title_sort | Modeling of Drug Release Kinetics from Stimuli- Responsive Micelles and Liposomes: A review |
| topic | Micelles Liposomes Drug release kinetics Mathematical modeling |
| url | http://hdl.handle.net/11073/21533 |