Redox-Responsive Drug Delivery Systems: A Chemical Perspective
With the widespread global impact of cancer on humans and the extensive side effects associated with current cancer treatments, a novel, effective, and safe treatment is needed. Redoxresponsive drug delivery systems (DDSs) have emerged as a potential cancer treatment with minimal side effects and en...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , |
| التنسيق: | article |
| منشور في: |
2022
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/11073/24104 |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513434081558528 |
|---|---|
| author | Abed, Heba |
| author2 | Abuwatfa, Waad Hussein Husseini, Ghaleb |
| author2_role | author author |
| author_facet | Abed, Heba Abuwatfa, Waad Hussein Husseini, Ghaleb |
| author_role | author |
| dc.creator.none.fl_str_mv | Abed, Heba Abuwatfa, Waad Hussein Husseini, Ghaleb |
| dc.date.none.fl_str_mv | 2022-09-14T06:26:01Z 2022-09-14T06:26:01Z 2022 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Abed, H.F.; Abuwatfa, W.H.; Husseini, G.A. Redox-Responsive Drug Delivery Systems: A Chemical Perspective. Nanomaterials 2022, 12, 3183. https://doi.org/10.3390/ nano12183183 2079-4991 http://hdl.handle.net/11073/24104 10.3390/ nano12183183 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | MDPI |
| dc.relation.none.fl_str_mv | https://doi.org/10.3390/nano12183183 |
| dc.subject.none.fl_str_mv | Drug delivery systems Redox-responsive Reducing Linkers Bonds |
| dc.title.none.fl_str_mv | Redox-Responsive Drug Delivery Systems: A Chemical Perspective |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | With the widespread global impact of cancer on humans and the extensive side effects associated with current cancer treatments, a novel, effective, and safe treatment is needed. Redoxresponsive drug delivery systems (DDSs) have emerged as a potential cancer treatment with minimal side effects and enhanced site-specific targeted delivery. This paper explores the physiological and biochemical nature of tumors that allow for redox-responsive drug delivery systems and reviews recent advances in the chemical composition and design of such systems. The five main redoxresponsive chemical entities that are the focus of this paper are disulfide bonds, diselenide bonds, succinimide–thioether linkages, tetrasulfide bonds, and platin conjugates. Moreover, as disulfide bonds are the most commonly used entities, the review explored disulfide-containing liposomes, polymeric micelles, and nanogels. While various systems have been devised, further research is needed to advance redox-responsive drug delivery systems for cancer treatment clinical applications. |
| format | article |
| id | aus_8b1bd4cf69e228b7a2d862515191fa8f |
| identifier_str_mv | Abed, H.F.; Abuwatfa, W.H.; Husseini, G.A. Redox-Responsive Drug Delivery Systems: A Chemical Perspective. Nanomaterials 2022, 12, 3183. https://doi.org/10.3390/ nano12183183 2079-4991 10.3390/ nano12183183 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/24104 |
| publishDate | 2022 |
| publisher.none.fl_str_mv | MDPI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Redox-Responsive Drug Delivery Systems: A Chemical PerspectiveAbed, HebaAbuwatfa, Waad HusseinHusseini, GhalebDrug delivery systemsRedox-responsiveReducingLinkersBondsWith the widespread global impact of cancer on humans and the extensive side effects associated with current cancer treatments, a novel, effective, and safe treatment is needed. Redoxresponsive drug delivery systems (DDSs) have emerged as a potential cancer treatment with minimal side effects and enhanced site-specific targeted delivery. This paper explores the physiological and biochemical nature of tumors that allow for redox-responsive drug delivery systems and reviews recent advances in the chemical composition and design of such systems. The five main redoxresponsive chemical entities that are the focus of this paper are disulfide bonds, diselenide bonds, succinimide–thioether linkages, tetrasulfide bonds, and platin conjugates. Moreover, as disulfide bonds are the most commonly used entities, the review explored disulfide-containing liposomes, polymeric micelles, and nanogels. While various systems have been devised, further research is needed to advance redox-responsive drug delivery systems for cancer treatment clinical applications.Dana Gas Endowed Chair for Chemical EngineeringAmerican University of SharjahSheikh Hamdan Award for Medical SciencesFriends of Cancer PatientsMDPI2022-09-14T06:26:01Z2022-09-14T06:26:01Z2022Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfAbed, H.F.; Abuwatfa, W.H.; Husseini, G.A. Redox-Responsive Drug Delivery Systems: A Chemical Perspective. Nanomaterials 2022, 12, 3183. https://doi.org/10.3390/ nano121831832079-4991http://hdl.handle.net/11073/2410410.3390/ nano12183183en_UShttps://doi.org/10.3390/nano12183183oai:repository.aus.edu:11073/241042024-08-22T12:05:31Z |
| spellingShingle | Redox-Responsive Drug Delivery Systems: A Chemical Perspective Abed, Heba Drug delivery systems Redox-responsive Reducing Linkers Bonds |
| status_str | publishedVersion |
| title | Redox-Responsive Drug Delivery Systems: A Chemical Perspective |
| title_full | Redox-Responsive Drug Delivery Systems: A Chemical Perspective |
| title_fullStr | Redox-Responsive Drug Delivery Systems: A Chemical Perspective |
| title_full_unstemmed | Redox-Responsive Drug Delivery Systems: A Chemical Perspective |
| title_short | Redox-Responsive Drug Delivery Systems: A Chemical Perspective |
| title_sort | Redox-Responsive Drug Delivery Systems: A Chemical Perspective |
| topic | Drug delivery systems Redox-responsive Reducing Linkers Bonds |
| url | http://hdl.handle.net/11073/24104 |