Finger-operated pumping platform for microfluidic preparation of nanoparticles
Microfluidic preparation of nanoparticles (NPs) offers many advantages over traditional bench-top preparation techniques, including better control over particle size and higher uniformity. Although many studies have reported the use of low-cost microfluidic chips for nanoparticle synthesis, the tech...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , |
| التنسيق: | article |
| منشور في: |
2024
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| الوصول للمادة أونلاين: | https://hdl.handle.net/11073/25562 |
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| _version_ | 1864513442119942144 |
|---|---|
| author | Azmeer, Ahmed |
| author2 | Kanan, Ibraheem Husseini, Ghaleb Abdelgawad, Mohammad |
| author2_role | author author author |
| author_facet | Azmeer, Ahmed Kanan, Ibraheem Husseini, Ghaleb Abdelgawad, Mohammad |
| author_role | author |
| dc.creator.none.fl_str_mv | Azmeer, Ahmed Kanan, Ibraheem Husseini, Ghaleb Abdelgawad, Mohammad |
| dc.date.none.fl_str_mv | 2024-07-04T06:50:10Z 2024-07-04T06:50:10Z 2024 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Azmeer, A., Kanan, I., Husseini, G.A. et al. Finger-operated pumping platform for microfluidic preparation of nanoparticles. Microfluid Nanofluid 28, 43 (2024). https://doi.org/10.1007/s10404-024-02738-8 1613-4982 https://hdl.handle.net/11073/25562 10.1007/s10404-024-02738-8 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | Springer |
| dc.relation.none.fl_str_mv | https://doi.org/10.1007/s10404-024-02738-8 https://rdcu.be/dKSjm |
| dc.title.none.fl_str_mv | Finger-operated pumping platform for microfluidic preparation of nanoparticles |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Microfluidic preparation of nanoparticles (NPs) offers many advantages over traditional bench-top preparation techniques, including better control over particle size and higher uniformity. Although many studies have reported the use of low-cost microfluidic chips for nanoparticle synthesis, the technology is still expensive due to the high cost of the pumps needed to generate the required flows inside microchannels. Here, we present a low-cost finger-operated constant-pressure pumping platform capable of generating pressures as high as 120 kPa using finger-operated pumping caps that can be attached to any pop bottle. The platform costs around $208 and enables the generation of flow rate ratios (FRR) of up to 47:1 for the continuous flow synthesis of NPs. The pump has a resolution of 500 Pa per stroke and exhibits stable pressures for up to a few hours. To show the functionality of the proposed pump, we used it to prepare pegylated liposomes and poly lacticco-glycolic acid (PLGA) nanoparticles with sizes ranging from 47 nm to 250 nm with an average polydispersity of 20% using commercially available micromixer chips and in-house made hydrodynamic flow focusing devices. We believe this platform will render microfluidic preparation of NPs accessible to any laboratory with minimal capabilities. |
| format | article |
| id | aus_909e883f4594f1c0aefdb1554b1d0962 |
| identifier_str_mv | Azmeer, A., Kanan, I., Husseini, G.A. et al. Finger-operated pumping platform for microfluidic preparation of nanoparticles. Microfluid Nanofluid 28, 43 (2024). https://doi.org/10.1007/s10404-024-02738-8 1613-4982 10.1007/s10404-024-02738-8 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/25562 |
| publishDate | 2024 |
| publisher.none.fl_str_mv | Springer |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Finger-operated pumping platform for microfluidic preparation of nanoparticlesAzmeer, AhmedKanan, IbraheemHusseini, GhalebAbdelgawad, MohammadMicrofluidic preparation of nanoparticles (NPs) offers many advantages over traditional bench-top preparation techniques, including better control over particle size and higher uniformity. Although many studies have reported the use of low-cost microfluidic chips for nanoparticle synthesis, the technology is still expensive due to the high cost of the pumps needed to generate the required flows inside microchannels. Here, we present a low-cost finger-operated constant-pressure pumping platform capable of generating pressures as high as 120 kPa using finger-operated pumping caps that can be attached to any pop bottle. The platform costs around $208 and enables the generation of flow rate ratios (FRR) of up to 47:1 for the continuous flow synthesis of NPs. The pump has a resolution of 500 Pa per stroke and exhibits stable pressures for up to a few hours. To show the functionality of the proposed pump, we used it to prepare pegylated liposomes and poly lacticco-glycolic acid (PLGA) nanoparticles with sizes ranging from 47 nm to 250 nm with an average polydispersity of 20% using commercially available micromixer chips and in-house made hydrodynamic flow focusing devices. We believe this platform will render microfluidic preparation of NPs accessible to any laboratory with minimal capabilities.Springer2024-07-04T06:50:10Z2024-07-04T06:50:10Z2024Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfAzmeer, A., Kanan, I., Husseini, G.A. et al. Finger-operated pumping platform for microfluidic preparation of nanoparticles. Microfluid Nanofluid 28, 43 (2024). https://doi.org/10.1007/s10404-024-02738-81613-4982https://hdl.handle.net/11073/2556210.1007/s10404-024-02738-8en_UShttps://doi.org/10.1007/s10404-024-02738-8https://rdcu.be/dKSjmoai:repository.aus.edu:11073/255622024-08-22T12:09:12Z |
| spellingShingle | Finger-operated pumping platform for microfluidic preparation of nanoparticles Azmeer, Ahmed |
| status_str | publishedVersion |
| title | Finger-operated pumping platform for microfluidic preparation of nanoparticles |
| title_full | Finger-operated pumping platform for microfluidic preparation of nanoparticles |
| title_fullStr | Finger-operated pumping platform for microfluidic preparation of nanoparticles |
| title_full_unstemmed | Finger-operated pumping platform for microfluidic preparation of nanoparticles |
| title_short | Finger-operated pumping platform for microfluidic preparation of nanoparticles |
| title_sort | Finger-operated pumping platform for microfluidic preparation of nanoparticles |
| url | https://hdl.handle.net/11073/25562 |