Release of Doxorubicin from Unstabilized and Stabilized Micelles Under the Action of Ultrasound
Polymeric micelles are being investigated as chemotherapy drug delivery carriers using ultrasound as a trigger mechanism. The aim of this paper is to measure the release of Doxorubicin (Dox) from the core of unstabilized Pluronic P105micelles , Pluronic P105micelles stabilized with an interpenetrati...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , |
| التنسيق: | article |
| منشور في: |
2007
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/11073/19732 |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513438888230912 |
|---|---|
| author | Husseini, Ghaleb |
| author2 | Diaz de la Rosa, Mario A. Gabuji, Tasneem Zeng, Yi Christensen, Douglas A. Pitt, William G. |
| author2_role | author author author author author |
| author_facet | Husseini, Ghaleb Diaz de la Rosa, Mario A. Gabuji, Tasneem Zeng, Yi Christensen, Douglas A. Pitt, William G. |
| author_role | author |
| dc.creator.none.fl_str_mv | Husseini, Ghaleb Diaz de la Rosa, Mario A. Gabuji, Tasneem Zeng, Yi Christensen, Douglas A. Pitt, William G. |
| dc.date.none.fl_str_mv | 2007 2020-08-27T07:27:43Z 2020-08-27T07:27:43Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Husseini, G. A., Diaz, de la R. M. A., Gabuji, T., Zeng, Y., Christensen, D. A., & Pitt, W. G. (2007). Release of doxorubicin from unstabilized and stabilized micelles under the action of ultrasound. Journal of Nanoscience and Nanotechnology, 7(3), 1028–33. 1533-4880 http://hdl.handle.net/11073/19732 10.1166/jnn.2007.218 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | American Scientific Publishers |
| dc.relation.none.fl_str_mv | https://doi.org/10.1166/jnn.2007.218 |
| dc.subject.none.fl_str_mv | Ultrasound Cavitation Events Doxorubicin Drug Delivery Micelle |
| dc.title.none.fl_str_mv | Release of Doxorubicin from Unstabilized and Stabilized Micelles Under the Action of Ultrasound |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Polymeric micelles are being investigated as chemotherapy drug delivery carriers using ultrasound as a trigger mechanism. The aim of this paper is to measure the release of Doxorubicin (Dox) from the core of unstabilized Pluronic P105micelles , Pluronic P105micelles stabilized with an interpenetrating network of N,N-diethylacrylamide, and micelles of poly(ethylene oxide)-b-poly (N-isopropylacrylamide)-b-poly(oligolactylmethacrylate) with stabilized cores. An ultrasonic exposure chamber with fluorescence detection was used to measure the release of the antineoplastic agent from both stabilized and unstabilized micelles. The release of Dox at 37 C from unstabilized Pluronic appears to be several times higher than release from the more stabilized and crosslinked copolymers at the same temperature. Although there is a difference in the amount of release between the different compounds, the onset of release occurs at about the same ultrasonic power density for all carriers investigated in this study. The threshold of drug release for all the compounds correlates to the emergence of subharmonic peaks detected in the acoustic spectra. We hypothesize that shearing events caused by cavitating bubbles play an important role in the acoustically activated release of chemotherapy agents delivered from various polymeric drug delivery vehicles. |
| format | article |
| id | aus_916822959ce9ef6f80dc666ae303f3ad |
| identifier_str_mv | Husseini, G. A., Diaz, de la R. M. A., Gabuji, T., Zeng, Y., Christensen, D. A., & Pitt, W. G. (2007). Release of doxorubicin from unstabilized and stabilized micelles under the action of ultrasound. Journal of Nanoscience and Nanotechnology, 7(3), 1028–33. 1533-4880 10.1166/jnn.2007.218 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/19732 |
| publishDate | 2007 |
| publisher.none.fl_str_mv | American Scientific Publishers |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Release of Doxorubicin from Unstabilized and Stabilized Micelles Under the Action of UltrasoundHusseini, GhalebDiaz de la Rosa, Mario A.Gabuji, TasneemZeng, YiChristensen, Douglas A.Pitt, William G.UltrasoundCavitation EventsDoxorubicinDrug DeliveryMicellePolymeric micelles are being investigated as chemotherapy drug delivery carriers using ultrasound as a trigger mechanism. The aim of this paper is to measure the release of Doxorubicin (Dox) from the core of unstabilized Pluronic P105micelles , Pluronic P105micelles stabilized with an interpenetrating network of N,N-diethylacrylamide, and micelles of poly(ethylene oxide)-b-poly (N-isopropylacrylamide)-b-poly(oligolactylmethacrylate) with stabilized cores. An ultrasonic exposure chamber with fluorescence detection was used to measure the release of the antineoplastic agent from both stabilized and unstabilized micelles. The release of Dox at 37 C from unstabilized Pluronic appears to be several times higher than release from the more stabilized and crosslinked copolymers at the same temperature. Although there is a difference in the amount of release between the different compounds, the onset of release occurs at about the same ultrasonic power density for all carriers investigated in this study. The threshold of drug release for all the compounds correlates to the emergence of subharmonic peaks detected in the acoustic spectra. We hypothesize that shearing events caused by cavitating bubbles play an important role in the acoustically activated release of chemotherapy agents delivered from various polymeric drug delivery vehicles.American Scientific Publishers2020-08-27T07:27:43Z2020-08-27T07:27:43Z2007Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfHusseini, G. A., Diaz, de la R. M. A., Gabuji, T., Zeng, Y., Christensen, D. A., & Pitt, W. G. (2007). Release of doxorubicin from unstabilized and stabilized micelles under the action of ultrasound. Journal of Nanoscience and Nanotechnology, 7(3), 1028–33.1533-4880http://hdl.handle.net/11073/1973210.1166/jnn.2007.218en_UShttps://doi.org/10.1166/jnn.2007.218oai:repository.aus.edu:11073/197322024-08-22T12:04:02Z |
| spellingShingle | Release of Doxorubicin from Unstabilized and Stabilized Micelles Under the Action of Ultrasound Husseini, Ghaleb Ultrasound Cavitation Events Doxorubicin Drug Delivery Micelle |
| status_str | publishedVersion |
| title | Release of Doxorubicin from Unstabilized and Stabilized Micelles Under the Action of Ultrasound |
| title_full | Release of Doxorubicin from Unstabilized and Stabilized Micelles Under the Action of Ultrasound |
| title_fullStr | Release of Doxorubicin from Unstabilized and Stabilized Micelles Under the Action of Ultrasound |
| title_full_unstemmed | Release of Doxorubicin from Unstabilized and Stabilized Micelles Under the Action of Ultrasound |
| title_short | Release of Doxorubicin from Unstabilized and Stabilized Micelles Under the Action of Ultrasound |
| title_sort | Release of Doxorubicin from Unstabilized and Stabilized Micelles Under the Action of Ultrasound |
| topic | Ultrasound Cavitation Events Doxorubicin Drug Delivery Micelle |
| url | http://hdl.handle.net/11073/19732 |