Hybrid liposome/metal–organic framework as a promising dual-responsive nanocarriers for anticancer drug delivery
In this work, liposome-coated iron (III) benzene-1,3,5-tricarboxylate (Fe-BTC) metal–organic framework is examined as a promising pH/Ultrasound dual-responsive nanocarriers for doxorubicin (DOX) delivery. The successful coating of the MOF particles (Lip-Fe-BTC) with the phospholipid bilayer (PBL) wa...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , |
| التنسيق: | article |
| منشور في: |
2022
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/11073/25518 |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513443363553280 |
|---|---|
| author | Karami, Abdollah |
| author2 | Ahmed, Ahmed H.S Sabouni, Rana Husseini, Ghaleb Al Sharabati, Miral Osama Yacoub AlSawaftah, Nour Majdi Paul, Vinod |
| author2_role | author author author author author author |
| author_facet | Karami, Abdollah Ahmed, Ahmed H.S Sabouni, Rana Husseini, Ghaleb Al Sharabati, Miral Osama Yacoub AlSawaftah, Nour Majdi Paul, Vinod |
| author_role | author |
| dc.creator.none.fl_str_mv | Karami, Abdollah Ahmed, Ahmed H.S Sabouni, Rana Husseini, Ghaleb Al Sharabati, Miral Osama Yacoub AlSawaftah, Nour Majdi Paul, Vinod |
| dc.date.none.fl_str_mv | 2022 2024-04-22T08:48:47Z 2024-04-22T08:48:47Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Karami, A.; Ahmed, A.; Sabouni, R.; Husseini, G. A.; Al Sharabati, M.; AlSawaftah,N.; Paul, V. Hybrid liposome/metal–organic framework as a promising dual-responsive nanocarriers for anticancer drug delivery, Colloids and Surfaces B: Biointerfaces, Volume 217, 2022, 112599, ISSN 0927-7765, https://doi.org/10.1016/j.colsurfb.2022.112599. 0927-7765 http://hdl.handle.net/11073/25518 10.1016/j.colsurfb.2022.112599 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.relation.none.fl_str_mv | https://doi.org/10.1016/j.colsurfb.2022.112599 |
| dc.subject.none.fl_str_mv | Metal–organic frameworks Drug delivery Ultrasound Triggered release Encapsulation efficiency Doxorubicin Fe-BTC Liposomes Phospholipid bilayer |
| dc.title.none.fl_str_mv | Hybrid liposome/metal–organic framework as a promising dual-responsive nanocarriers for anticancer drug delivery |
| dc.type.none.fl_str_mv | Peer-Reviewed Postprint info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | In this work, liposome-coated iron (III) benzene-1,3,5-tricarboxylate (Fe-BTC) metal–organic framework is examined as a promising pH/Ultrasound dual-responsive nanocarriers for doxorubicin (DOX) delivery. The successful coating of the MOF particles (Lip-Fe-BTC) with the phospholipid bilayer (PBL) was established by direct fusion into the synthesized liposomes. The liposome coating was verified using several techniques, including dynamic light scattering (DLS) and transmission electron microscopy (TEM). The DLS measurements showed an increase in the average particle diameter of liposomes from 150 nm to 163.1 nm for Lip-Fe-BTC particles. The Fe-BTC particles had the highest average particle diameter (287.3 nm). These results demonstrated that the PBL reduced the aggregation of the particles and improved their dispersity in the release medium. The TGA results demonstrated the MOF’s excellent thermal stability. Furthermore, the nanocarrier’s loading efficiency and capacity were determined to be ~90% and ~13.5 wt%, respectively. The in-vitro DOX release experiments demonstrated that the DOX-loaded Fe-BTC and liposome-coated Fe-BTC particles showed good pH and US dual-responsive capability, making them promising nanocarriers for drug delivery. The application of US enhanced DOX release from both Fe-BTC and liposome-coated Fe-BTC. In the case of Fe-BTC-DOX particles, the application of US enhanced the DOX release to around 38% and 67%, at pH levels of 7.4 and 5.3, respectively. Similarly, DOX release from the Lip-Fe-BTC-DOX particles reached ~35% and ~53%, at pH levels of 7.4 and 5.3, respectively. The MTT assay showed the biocompatibility and low cytotoxicity of these nanocarriers below 100 µg/ml. |
| format | article |
| id | aus_937912f95a5f8fc061c74987c0ffbb08 |
| identifier_str_mv | Karami, A.; Ahmed, A.; Sabouni, R.; Husseini, G. A.; Al Sharabati, M.; AlSawaftah,N.; Paul, V. Hybrid liposome/metal–organic framework as a promising dual-responsive nanocarriers for anticancer drug delivery, Colloids and Surfaces B: Biointerfaces, Volume 217, 2022, 112599, ISSN 0927-7765, https://doi.org/10.1016/j.colsurfb.2022.112599. 0927-7765 10.1016/j.colsurfb.2022.112599 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/25518 |
| publishDate | 2022 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Hybrid liposome/metal–organic framework as a promising dual-responsive nanocarriers for anticancer drug deliveryKarami, AbdollahAhmed, Ahmed H.SSabouni, RanaHusseini, GhalebAl Sharabati, Miral Osama YacoubAlSawaftah, Nour MajdiPaul, VinodMetal–organic frameworksDrug deliveryUltrasoundTriggered releaseEncapsulation efficiencyDoxorubicinFe-BTCLiposomesPhospholipid bilayerIn this work, liposome-coated iron (III) benzene-1,3,5-tricarboxylate (Fe-BTC) metal–organic framework is examined as a promising pH/Ultrasound dual-responsive nanocarriers for doxorubicin (DOX) delivery. The successful coating of the MOF particles (Lip-Fe-BTC) with the phospholipid bilayer (PBL) was established by direct fusion into the synthesized liposomes. The liposome coating was verified using several techniques, including dynamic light scattering (DLS) and transmission electron microscopy (TEM). The DLS measurements showed an increase in the average particle diameter of liposomes from 150 nm to 163.1 nm for Lip-Fe-BTC particles. The Fe-BTC particles had the highest average particle diameter (287.3 nm). These results demonstrated that the PBL reduced the aggregation of the particles and improved their dispersity in the release medium. The TGA results demonstrated the MOF’s excellent thermal stability. Furthermore, the nanocarrier’s loading efficiency and capacity were determined to be ~90% and ~13.5 wt%, respectively. The in-vitro DOX release experiments demonstrated that the DOX-loaded Fe-BTC and liposome-coated Fe-BTC particles showed good pH and US dual-responsive capability, making them promising nanocarriers for drug delivery. The application of US enhanced DOX release from both Fe-BTC and liposome-coated Fe-BTC. In the case of Fe-BTC-DOX particles, the application of US enhanced the DOX release to around 38% and 67%, at pH levels of 7.4 and 5.3, respectively. Similarly, DOX release from the Lip-Fe-BTC-DOX particles reached ~35% and ~53%, at pH levels of 7.4 and 5.3, respectively. The MTT assay showed the biocompatibility and low cytotoxicity of these nanocarriers below 100 µg/ml.American University of SharjahElsevier2024-04-22T08:48:47Z2024-04-22T08:48:47Z2022Peer-ReviewedPostprintinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfKarami, A.; Ahmed, A.; Sabouni, R.; Husseini, G. A.; Al Sharabati, M.; AlSawaftah,N.; Paul, V. Hybrid liposome/metal–organic framework as a promising dual-responsive nanocarriers for anticancer drug delivery, Colloids and Surfaces B: Biointerfaces, Volume 217, 2022, 112599, ISSN 0927-7765, https://doi.org/10.1016/j.colsurfb.2022.112599.0927-7765http://hdl.handle.net/11073/2551810.1016/j.colsurfb.2022.112599en_UShttps://doi.org/10.1016/j.colsurfb.2022.112599oai:repository.aus.edu:11073/255182024-08-22T12:05:52Z |
| spellingShingle | Hybrid liposome/metal–organic framework as a promising dual-responsive nanocarriers for anticancer drug delivery Karami, Abdollah Metal–organic frameworks Drug delivery Ultrasound Triggered release Encapsulation efficiency Doxorubicin Fe-BTC Liposomes Phospholipid bilayer |
| status_str | publishedVersion |
| title | Hybrid liposome/metal–organic framework as a promising dual-responsive nanocarriers for anticancer drug delivery |
| title_full | Hybrid liposome/metal–organic framework as a promising dual-responsive nanocarriers for anticancer drug delivery |
| title_fullStr | Hybrid liposome/metal–organic framework as a promising dual-responsive nanocarriers for anticancer drug delivery |
| title_full_unstemmed | Hybrid liposome/metal–organic framework as a promising dual-responsive nanocarriers for anticancer drug delivery |
| title_short | Hybrid liposome/metal–organic framework as a promising dual-responsive nanocarriers for anticancer drug delivery |
| title_sort | Hybrid liposome/metal–organic framework as a promising dual-responsive nanocarriers for anticancer drug delivery |
| topic | Metal–organic frameworks Drug delivery Ultrasound Triggered release Encapsulation efficiency Doxorubicin Fe-BTC Liposomes Phospholipid bilayer |
| url | http://hdl.handle.net/11073/25518 |