Whole Organism Model to Study Molecular Mechanisms of Differentiation and Dedifferentiation
Cancer recurrence has remained a significant challenge, despite advances in therapeutic approaches. In part, this is due to our incomplete understanding of the biology of cancer stem cells and the underlying molecular mechanisms. The phenomenon of differentiation and dedifferentiation (phenotypic sw...
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| Format: | article |
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2020
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| Online Access: | http://hdl.handle.net/11073/21416 |
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| _version_ | 1864513442026618880 |
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| author | Anwar, Areeba |
| author2 | Siddiqui, Ruqaiyyah Khan, Naveed |
| author2_role | author author |
| author_facet | Anwar, Areeba Siddiqui, Ruqaiyyah Khan, Naveed |
| author_role | author |
| dc.creator.none.fl_str_mv | Anwar, Areeba Siddiqui, Ruqaiyyah Khan, Naveed |
| dc.date.none.fl_str_mv | 2020 2021-04-15T09:57:05Z 2021-04-15T09:57:05Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Anwar, A.; Siddiqui, R.; Khan, N.A. Whole Organism Model to Study Molecular Mechanisms of Differentiation and Dedifferentiation. Biology 2020, 9, 79. https://doi.org/10.3390/biology9040079 2079-7737 http://hdl.handle.net/11073/21416 10.3390/biology9040079 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | MDPI |
| dc.relation.none.fl_str_mv | https://doi.org/10.3390/biology9040079 |
| dc.subject.none.fl_str_mv | Cell differentiation Cancer Acanthamoeba Phenotypic switching Encystation Protozoa Cancer stem cells Dedifferentiation Signalling Apoptosis |
| dc.title.none.fl_str_mv | Whole Organism Model to Study Molecular Mechanisms of Differentiation and Dedifferentiation |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Cancer recurrence has remained a significant challenge, despite advances in therapeutic approaches. In part, this is due to our incomplete understanding of the biology of cancer stem cells and the underlying molecular mechanisms. The phenomenon of differentiation and dedifferentiation (phenotypic switching) is not only unique to stem cells but it is also observed in several other organisms, as well as evolutionary-related microbes. Here, we propose the use of a primitive eukaryotic unicellular organism, Acanthamoeba castellanii, as a model to study the molecular mechanisms of cellular differentiation and dedifferentiation. |
| format | article |
| id | aus_943e8012a63a11288b54eb0fb65f3d7b |
| identifier_str_mv | Anwar, A.; Siddiqui, R.; Khan, N.A. Whole Organism Model to Study Molecular Mechanisms of Differentiation and Dedifferentiation. Biology 2020, 9, 79. https://doi.org/10.3390/biology9040079 2079-7737 10.3390/biology9040079 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/21416 |
| publishDate | 2020 |
| publisher.none.fl_str_mv | MDPI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
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| spelling | Whole Organism Model to Study Molecular Mechanisms of Differentiation and DedifferentiationAnwar, AreebaSiddiqui, RuqaiyyahKhan, NaveedCell differentiationCancerAcanthamoebaPhenotypic switchingEncystationProtozoaCancer stem cellsDedifferentiationSignallingApoptosisCancer recurrence has remained a significant challenge, despite advances in therapeutic approaches. In part, this is due to our incomplete understanding of the biology of cancer stem cells and the underlying molecular mechanisms. The phenomenon of differentiation and dedifferentiation (phenotypic switching) is not only unique to stem cells but it is also observed in several other organisms, as well as evolutionary-related microbes. Here, we propose the use of a primitive eukaryotic unicellular organism, Acanthamoeba castellanii, as a model to study the molecular mechanisms of cellular differentiation and dedifferentiation.American University of SharjahMDPI2021-04-15T09:57:05Z2021-04-15T09:57:05Z2020Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfAnwar, A.; Siddiqui, R.; Khan, N.A. Whole Organism Model to Study Molecular Mechanisms of Differentiation and Dedifferentiation. Biology 2020, 9, 79. https://doi.org/10.3390/biology90400792079-7737http://hdl.handle.net/11073/2141610.3390/biology9040079en_UShttps://doi.org/10.3390/biology9040079oai:repository.aus.edu:11073/214162024-08-22T11:59:54Z |
| spellingShingle | Whole Organism Model to Study Molecular Mechanisms of Differentiation and Dedifferentiation Anwar, Areeba Cell differentiation Cancer Acanthamoeba Phenotypic switching Encystation Protozoa Cancer stem cells Dedifferentiation Signalling Apoptosis |
| status_str | publishedVersion |
| title | Whole Organism Model to Study Molecular Mechanisms of Differentiation and Dedifferentiation |
| title_full | Whole Organism Model to Study Molecular Mechanisms of Differentiation and Dedifferentiation |
| title_fullStr | Whole Organism Model to Study Molecular Mechanisms of Differentiation and Dedifferentiation |
| title_full_unstemmed | Whole Organism Model to Study Molecular Mechanisms of Differentiation and Dedifferentiation |
| title_short | Whole Organism Model to Study Molecular Mechanisms of Differentiation and Dedifferentiation |
| title_sort | Whole Organism Model to Study Molecular Mechanisms of Differentiation and Dedifferentiation |
| topic | Cell differentiation Cancer Acanthamoeba Phenotypic switching Encystation Protozoa Cancer stem cells Dedifferentiation Signalling Apoptosis |
| url | http://hdl.handle.net/11073/21416 |