Acoustically-Activated Liposomal Nanocarriers to Mitigate the Side Effects of Conventional Chemotherapy with a Focus on Emulsion-Liposomes
To improve currently available cancer treatments, nanomaterials are employed as smart drug delivery vehicles that can be engineered to locally target cancer cells and respond to stimuli. Nanocarriers can entrap chemotherapeutic drugs and deliver them to the diseased site, reducing the side effects a...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , |
| التنسيق: | article |
| منشور في: |
2023
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/11073/25116 |
| الوسوم: |
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| _version_ | 1864513442403057664 |
|---|---|
| author | Zafar, Mah Noor |
| author2 | Abuwatfa, Waad Hussein Husseini, Ghaleb |
| author2_role | author author |
| author_facet | Zafar, Mah Noor Abuwatfa, Waad Hussein Husseini, Ghaleb |
| author_role | author |
| dc.creator.none.fl_str_mv | Zafar, Mah Noor Abuwatfa, Waad Hussein Husseini, Ghaleb |
| dc.date.none.fl_str_mv | 2023-01-30T07:28:32Z 2023-01-30T07:28:32Z 2023 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Zafar, M.N.; Abuwatfa, W.H.; Husseini, G.A. Acoustically-Activated Liposomal Nanocarriers to Mitigate the Side Effects of Conventional Chemotherapy with a Focus on Emulsion-Liposomes. Pharmaceutics 2023, 15, 421. https://doi.org/10.3390/pharmaceutics15020421 1999-4923 http://hdl.handle.net/11073/25116 10.3390/pharmaceutics15020421 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | MDPI |
| dc.relation.none.fl_str_mv | https://doi.org/10.3390/pharmaceutics15020421 |
| dc.subject.none.fl_str_mv | eLiposomes Emulsion liposomes Ultrasound Drug-delivery |
| dc.title.none.fl_str_mv | Acoustically-Activated Liposomal Nanocarriers to Mitigate the Side Effects of Conventional Chemotherapy with a Focus on Emulsion-Liposomes |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | To improve currently available cancer treatments, nanomaterials are employed as smart drug delivery vehicles that can be engineered to locally target cancer cells and respond to stimuli. Nanocarriers can entrap chemotherapeutic drugs and deliver them to the diseased site, reducing the side effects associated with the systemic administration of conventional anticancer drugs. Upon accumulation in the tumor cells, the nanocarriers need to be potentiated to release their therapeutic cargo. Stimulation can be through endogenous or exogenous modalities, such as temperature, electromagnetic irradiation, ultrasound (US), pH, or enzymes. This review discusses the acoustic stimulation of different sonosensitive liposomal formulations. Emulsion liposomes, or eLiposomes, are liposomes encapsulating phase-changing nanoemulsion droplets, which promote acoustic droplet vaporization (ADV) upon sonication. This gives eLiposomes the advantage of delivering the encapsulated drug at low intensities and short exposure times relative to liposomes. Other formulations integrating microbubbles and nanobubbles are also discussed. |
| format | article |
| id | aus_94642eb6e83c72b86a3017ac2b82a419 |
| identifier_str_mv | Zafar, M.N.; Abuwatfa, W.H.; Husseini, G.A. Acoustically-Activated Liposomal Nanocarriers to Mitigate the Side Effects of Conventional Chemotherapy with a Focus on Emulsion-Liposomes. Pharmaceutics 2023, 15, 421. https://doi.org/10.3390/pharmaceutics15020421 1999-4923 10.3390/pharmaceutics15020421 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/25116 |
| publishDate | 2023 |
| publisher.none.fl_str_mv | MDPI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Acoustically-Activated Liposomal Nanocarriers to Mitigate the Side Effects of Conventional Chemotherapy with a Focus on Emulsion-LiposomesZafar, Mah NoorAbuwatfa, Waad HusseinHusseini, GhalebeLiposomesEmulsion liposomesUltrasoundDrug-deliveryTo improve currently available cancer treatments, nanomaterials are employed as smart drug delivery vehicles that can be engineered to locally target cancer cells and respond to stimuli. Nanocarriers can entrap chemotherapeutic drugs and deliver them to the diseased site, reducing the side effects associated with the systemic administration of conventional anticancer drugs. Upon accumulation in the tumor cells, the nanocarriers need to be potentiated to release their therapeutic cargo. Stimulation can be through endogenous or exogenous modalities, such as temperature, electromagnetic irradiation, ultrasound (US), pH, or enzymes. This review discusses the acoustic stimulation of different sonosensitive liposomal formulations. Emulsion liposomes, or eLiposomes, are liposomes encapsulating phase-changing nanoemulsion droplets, which promote acoustic droplet vaporization (ADV) upon sonication. This gives eLiposomes the advantage of delivering the encapsulated drug at low intensities and short exposure times relative to liposomes. Other formulations integrating microbubbles and nanobubbles are also discussed.Dana Gas Endowed Chair for Chemical EngineeringAmerican University of SharjahSheikh Hamdan Award for Medical SciencesFriends of Cancer Patients (FoCP)MDPI2023-01-30T07:28:32Z2023-01-30T07:28:32Z2023Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfZafar, M.N.; Abuwatfa, W.H.; Husseini, G.A. Acoustically-Activated Liposomal Nanocarriers to Mitigate the Side Effects of Conventional Chemotherapy with a Focus on Emulsion-Liposomes. Pharmaceutics 2023, 15, 421. https://doi.org/10.3390/pharmaceutics150204211999-4923http://hdl.handle.net/11073/2511610.3390/pharmaceutics15020421en_UShttps://doi.org/10.3390/pharmaceutics15020421oai:repository.aus.edu:11073/251162024-08-22T12:05:20Z |
| spellingShingle | Acoustically-Activated Liposomal Nanocarriers to Mitigate the Side Effects of Conventional Chemotherapy with a Focus on Emulsion-Liposomes Zafar, Mah Noor eLiposomes Emulsion liposomes Ultrasound Drug-delivery |
| status_str | publishedVersion |
| title | Acoustically-Activated Liposomal Nanocarriers to Mitigate the Side Effects of Conventional Chemotherapy with a Focus on Emulsion-Liposomes |
| title_full | Acoustically-Activated Liposomal Nanocarriers to Mitigate the Side Effects of Conventional Chemotherapy with a Focus on Emulsion-Liposomes |
| title_fullStr | Acoustically-Activated Liposomal Nanocarriers to Mitigate the Side Effects of Conventional Chemotherapy with a Focus on Emulsion-Liposomes |
| title_full_unstemmed | Acoustically-Activated Liposomal Nanocarriers to Mitigate the Side Effects of Conventional Chemotherapy with a Focus on Emulsion-Liposomes |
| title_short | Acoustically-Activated Liposomal Nanocarriers to Mitigate the Side Effects of Conventional Chemotherapy with a Focus on Emulsion-Liposomes |
| title_sort | Acoustically-Activated Liposomal Nanocarriers to Mitigate the Side Effects of Conventional Chemotherapy with a Focus on Emulsion-Liposomes |
| topic | eLiposomes Emulsion liposomes Ultrasound Drug-delivery |
| url | http://hdl.handle.net/11073/25116 |