Ultrasound-sensitive cRGD-modified liposomes as a novel drug delivery system
Targeted liposomes enable the delivery of encapsulated chemotherapeutics to tumours by targeting specific receptors overexpressed on the surfaces of cancer cells; this helps in reducing the systemic side effects associated with the cytotoxic agents. Upon reaching the targeted site, these liposomes c...
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| Other Authors: | , , , , |
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2022
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| Online Access: | http://hdl.handle.net/11073/23633 |
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| _version_ | 1864513436610723840 |
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| author | AlSawaftah, Nour Majdi |
| author2 | Paul, Vinod Kosaji, Doua Jamal Khabbaz, Leen Awad, Nahid S. Husseini, Ghaleb |
| author2_role | author author author author author |
| author_facet | AlSawaftah, Nour Majdi Paul, Vinod Kosaji, Doua Jamal Khabbaz, Leen Awad, Nahid S. Husseini, Ghaleb |
| author_role | author |
| dc.creator.none.fl_str_mv | AlSawaftah, Nour Majdi Paul, Vinod Kosaji, Doua Jamal Khabbaz, Leen Awad, Nahid S. Husseini, Ghaleb |
| dc.date.none.fl_str_mv | 2022-05-17T05:56:23Z 2022-05-17T05:56:23Z 2022 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | AlSawaftah, N; Paul, V; Kosajia, D; Khabbaz, L; Awad, N; Husseini, G. Ultrasound-sensitive cRGD-modified liposomes as a novel drug delivery system. Artificial Cells, Nanomedicine, and Biotechnology 2022, 50, 1. https://doi.org/10.1080/21691401.2022.2074439 2169-141X http://hdl.handle.net/11073/23633 10.1080/21691401.2022.2074439 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | Taylor & Francis |
| dc.relation.none.fl_str_mv | https://doi.org/10.1080/21691401.2022.2074439 |
| dc.subject.none.fl_str_mv | Cancer Liposomes cRGD Ultrasound Calcein |
| dc.title.none.fl_str_mv | Ultrasound-sensitive cRGD-modified liposomes as a novel drug delivery system |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Targeted liposomes enable the delivery of encapsulated chemotherapeutics to tumours by targeting specific receptors overexpressed on the surfaces of cancer cells; this helps in reducing the systemic side effects associated with the cytotoxic agents. Upon reaching the targeted site, these liposomes can be triggered to release their payloads using internal or external triggers. In this study, we investigate the use of low-frequency ultrasound as an external modality to trigger the release of a model drug (calcein) from non-targeted and targeted pegylated liposomes modified with cyclic arginine–glycine–aspartate (cRGD). Liposomes were exposed to sonication at 20-kHz using three different power densities (6.2, 9, and 10 mW/cm²). Our results showed that increasing the power density increased calcein release from the sonicated liposomes. Moreover, cRGD conjugation to the surface of the liposomes rendered cRGD-liposomes more susceptible to ultrasound compared to the non-targeted liposomes. cRGD conjugation was also found to increase cellular uptake of calcein by human colorectal carcinoma (HCT116) cells which were further enhanced following sonicating the cells with low-frequency ultrasound (LFUS). |
| format | article |
| id | aus_a40677ec11b180ae029615f8fbc9c508 |
| identifier_str_mv | AlSawaftah, N; Paul, V; Kosajia, D; Khabbaz, L; Awad, N; Husseini, G. Ultrasound-sensitive cRGD-modified liposomes as a novel drug delivery system. Artificial Cells, Nanomedicine, and Biotechnology 2022, 50, 1. https://doi.org/10.1080/21691401.2022.2074439 2169-141X 10.1080/21691401.2022.2074439 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/23633 |
| publishDate | 2022 |
| publisher.none.fl_str_mv | Taylor & Francis |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Ultrasound-sensitive cRGD-modified liposomes as a novel drug delivery systemAlSawaftah, Nour MajdiPaul, VinodKosaji, Doua JamalKhabbaz, LeenAwad, Nahid S.Husseini, GhalebCancerLiposomescRGDUltrasoundCalceinTargeted liposomes enable the delivery of encapsulated chemotherapeutics to tumours by targeting specific receptors overexpressed on the surfaces of cancer cells; this helps in reducing the systemic side effects associated with the cytotoxic agents. Upon reaching the targeted site, these liposomes can be triggered to release their payloads using internal or external triggers. In this study, we investigate the use of low-frequency ultrasound as an external modality to trigger the release of a model drug (calcein) from non-targeted and targeted pegylated liposomes modified with cyclic arginine–glycine–aspartate (cRGD). Liposomes were exposed to sonication at 20-kHz using three different power densities (6.2, 9, and 10 mW/cm²). Our results showed that increasing the power density increased calcein release from the sonicated liposomes. Moreover, cRGD conjugation to the surface of the liposomes rendered cRGD-liposomes more susceptible to ultrasound compared to the non-targeted liposomes. cRGD conjugation was also found to increase cellular uptake of calcein by human colorectal carcinoma (HCT116) cells which were further enhanced following sonicating the cells with low-frequency ultrasound (LFUS).American University of SharjahSheikh Hamdan Award for Medical SciencesFriends of Cancer PatientsTaylor & Francis2022-05-17T05:56:23Z2022-05-17T05:56:23Z2022Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfAlSawaftah, N; Paul, V; Kosajia, D; Khabbaz, L; Awad, N; Husseini, G. Ultrasound-sensitive cRGD-modified liposomes as a novel drug delivery system. Artificial Cells, Nanomedicine, and Biotechnology 2022, 50, 1. https://doi.org/10.1080/21691401.2022.20744392169-141Xhttp://hdl.handle.net/11073/2363310.1080/21691401.2022.2074439en_UShttps://doi.org/10.1080/21691401.2022.2074439oai:repository.aus.edu:11073/236332024-08-22T12:05:40Z |
| spellingShingle | Ultrasound-sensitive cRGD-modified liposomes as a novel drug delivery system AlSawaftah, Nour Majdi Cancer Liposomes cRGD Ultrasound Calcein |
| status_str | publishedVersion |
| title | Ultrasound-sensitive cRGD-modified liposomes as a novel drug delivery system |
| title_full | Ultrasound-sensitive cRGD-modified liposomes as a novel drug delivery system |
| title_fullStr | Ultrasound-sensitive cRGD-modified liposomes as a novel drug delivery system |
| title_full_unstemmed | Ultrasound-sensitive cRGD-modified liposomes as a novel drug delivery system |
| title_short | Ultrasound-sensitive cRGD-modified liposomes as a novel drug delivery system |
| title_sort | Ultrasound-sensitive cRGD-modified liposomes as a novel drug delivery system |
| topic | Cancer Liposomes cRGD Ultrasound Calcein |
| url | http://hdl.handle.net/11073/23633 |