Comparing microbubble cavitation at 500 kHz and 70 kHz related to micellar drug delivery using ultrasound
We have previously reported that ultrasonic drug release at 70 kHz was found to correlate with the presence of subharmonic emissions. No evidence of drug release or of the subharmonic emissions were detected in experiments at 500 kHz. In an attempt to understand the difference in drug release behavi...
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| مؤلفون آخرون: | , |
| التنسيق: | article |
| منشور في: |
2013
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/11073/21300 |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513437188489216 |
|---|---|
| author | Diaz de la Rosa, Mario A. |
| author2 | Husseini, Ghaleb Pitt, William G. |
| author2_role | author author |
| author_facet | Diaz de la Rosa, Mario A. Husseini, Ghaleb Pitt, William G. |
| author_role | author |
| dc.creator.none.fl_str_mv | Diaz de la Rosa, Mario A. Husseini, Ghaleb Pitt, William G. |
| dc.date.none.fl_str_mv | 2013 2021-01-28T07:03:35Z 2021-01-28T07:03:35Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Mario A. Diaz de la Rosa, Ghaleb A. Husseini, William G. Pitt, Comparing microbubble cavitation at 500kHz and 70kHz related to micellar drug delivery using ultrasound, Ultrasonics, Volume 53, Issue 2, 2013, Pages 377-386, ISSN 0041-624X, https://doi.org/10.1016/j.ultras.2012.07.004. 0041-624X http://hdl.handle.net/11073/21300 10.1016/j.ultras.2012.07.004 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.relation.none.fl_str_mv | https://doi.org/10.1016/j.ultras.2012.07.004 |
| dc.subject.none.fl_str_mv | Bubble Dynamic behavior Cavitation Ultrasound Sub-harmonic |
| dc.title.none.fl_str_mv | Comparing microbubble cavitation at 500 kHz and 70 kHz related to micellar drug delivery using ultrasound |
| dc.type.none.fl_str_mv | Peer-Reviewed Postprint info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | We have previously reported that ultrasonic drug release at 70 kHz was found to correlate with the presence of subharmonic emissions. No evidence of drug release or of the subharmonic emissions were detected in experiments at 500 kHz. In an attempt to understand the difference in drug release behavior between low- and mid-frequency ultrasound, a mathematical model of a bubble oscillator was developed to explore the difference in the behavior of a single 10-μm bubble under 500- and 70-kHz ultrasound. The dynamics were found to be fundamentally different; the 500-kHz bubble follows a period-doubling route to chaos while a 70-kHz bubble follows an intermittent route to chaos. We propose that this type of “intermittent subharmonic” oscillation behavior is associated with the drug release observed experimentally. |
| format | article |
| id | aus_a719f43c375db14c8b9c93f201a99815 |
| identifier_str_mv | Mario A. Diaz de la Rosa, Ghaleb A. Husseini, William G. Pitt, Comparing microbubble cavitation at 500kHz and 70kHz related to micellar drug delivery using ultrasound, Ultrasonics, Volume 53, Issue 2, 2013, Pages 377-386, ISSN 0041-624X, https://doi.org/10.1016/j.ultras.2012.07.004. 0041-624X 10.1016/j.ultras.2012.07.004 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/21300 |
| publishDate | 2013 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Comparing microbubble cavitation at 500 kHz and 70 kHz related to micellar drug delivery using ultrasoundDiaz de la Rosa, Mario A.Husseini, GhalebPitt, William G.BubbleDynamic behaviorCavitationUltrasoundSub-harmonicWe have previously reported that ultrasonic drug release at 70 kHz was found to correlate with the presence of subharmonic emissions. No evidence of drug release or of the subharmonic emissions were detected in experiments at 500 kHz. In an attempt to understand the difference in drug release behavior between low- and mid-frequency ultrasound, a mathematical model of a bubble oscillator was developed to explore the difference in the behavior of a single 10-μm bubble under 500- and 70-kHz ultrasound. The dynamics were found to be fundamentally different; the 500-kHz bubble follows a period-doubling route to chaos while a 70-kHz bubble follows an intermittent route to chaos. We propose that this type of “intermittent subharmonic” oscillation behavior is associated with the drug release observed experimentally.Elsevier2021-01-28T07:03:35Z2021-01-28T07:03:35Z2013Peer-ReviewedPostprintinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfMario A. Diaz de la Rosa, Ghaleb A. Husseini, William G. Pitt, Comparing microbubble cavitation at 500kHz and 70kHz related to micellar drug delivery using ultrasound, Ultrasonics, Volume 53, Issue 2, 2013, Pages 377-386, ISSN 0041-624X, https://doi.org/10.1016/j.ultras.2012.07.004.0041-624Xhttp://hdl.handle.net/11073/2130010.1016/j.ultras.2012.07.004en_UShttps://doi.org/10.1016/j.ultras.2012.07.004oai:repository.aus.edu:11073/213002024-08-22T12:04:35Z |
| spellingShingle | Comparing microbubble cavitation at 500 kHz and 70 kHz related to micellar drug delivery using ultrasound Diaz de la Rosa, Mario A. Bubble Dynamic behavior Cavitation Ultrasound Sub-harmonic |
| status_str | publishedVersion |
| title | Comparing microbubble cavitation at 500 kHz and 70 kHz related to micellar drug delivery using ultrasound |
| title_full | Comparing microbubble cavitation at 500 kHz and 70 kHz related to micellar drug delivery using ultrasound |
| title_fullStr | Comparing microbubble cavitation at 500 kHz and 70 kHz related to micellar drug delivery using ultrasound |
| title_full_unstemmed | Comparing microbubble cavitation at 500 kHz and 70 kHz related to micellar drug delivery using ultrasound |
| title_short | Comparing microbubble cavitation at 500 kHz and 70 kHz related to micellar drug delivery using ultrasound |
| title_sort | Comparing microbubble cavitation at 500 kHz and 70 kHz related to micellar drug delivery using ultrasound |
| topic | Bubble Dynamic behavior Cavitation Ultrasound Sub-harmonic |
| url | http://hdl.handle.net/11073/21300 |