Kinetics of Ultrasonic Drug Delivery from Targeted Micelles
To minimize the adverse side effects of conventional chemotherapy, a targeted micellar drug carrier was investigated that retains hydrophobic drugs in its core and then releases the drug via ultrasonic activation. This paper compares the percent drug release from folated versus non-folated micelles...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , |
| التنسيق: | article |
| منشور في: |
2015
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/11073/19740 |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513441246478336 |
|---|---|
| author | Husseini, Ghaleb |
| author2 | Kherbeck, Laura Pitt, William G. Christensen, Douglas A. Velluto, Diana |
| author2_role | author author author author |
| author_facet | Husseini, Ghaleb Kherbeck, Laura Pitt, William G. Christensen, Douglas A. Velluto, Diana |
| author_role | author |
| dc.creator.none.fl_str_mv | Husseini, Ghaleb Kherbeck, Laura Pitt, William G. Christensen, Douglas A. Velluto, Diana |
| dc.date.none.fl_str_mv | 2015 2020-08-27T12:04:23Z 2020-08-27T12:04:23Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Husseini, G. A., Kherbeck, L., Pitt, W. G., Hubbell, J. A., Christensen, D. A., & Velluto, D. (2015). Kinetics of ultrasonic drug delivery from targeted micelles. Journal of Nanoscience and Nanotechnology, 15(3), 2099–2104. https://doi.org/10.1166/jnn.2015.9498 1533-4880 http://hdl.handle.net/11073/19740 10.1166/jnn.2015.9498 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | American Scientific Publishers |
| dc.relation.none.fl_str_mv | https://doi.org/10.1166/jnn.2015.9498 |
| dc.subject.none.fl_str_mv | Folated Micelles Kinetic Models 70-kHz Ultrasound Pluronic P105 Drug Release Re-encapsulation Targeted Drug Delivery |
| dc.title.none.fl_str_mv | Kinetics of Ultrasonic Drug Delivery from Targeted Micelles |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | To minimize the adverse side effects of conventional chemotherapy, a targeted micellar drug carrier was investigated that retains hydrophobic drugs in its core and then releases the drug via ultrasonic activation. This paper compares the percent drug release from folated versus non-folated micelles by insonation at 70 kHz and different acoustic power densities. The encapsulated drug is Doxorubicin (Dox). A physical model of zero-order release with first-order re-encapsulation was used to fit the experimental kinetic data. Additionally, the acoustic activation power density and Gibbs free energy were introduced and calculated for folated and non-targeted micelles. The data suggests an important role of inertial cavitation in drug release and the presence of a power density threshold for inertial cavitation. |
| format | article |
| id | aus_af90c8b623df4aede14c5165ed77de42 |
| identifier_str_mv | Husseini, G. A., Kherbeck, L., Pitt, W. G., Hubbell, J. A., Christensen, D. A., & Velluto, D. (2015). Kinetics of ultrasonic drug delivery from targeted micelles. Journal of Nanoscience and Nanotechnology, 15(3), 2099–2104. https://doi.org/10.1166/jnn.2015.9498 1533-4880 10.1166/jnn.2015.9498 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/19740 |
| publishDate | 2015 |
| publisher.none.fl_str_mv | American Scientific Publishers |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Kinetics of Ultrasonic Drug Delivery from Targeted MicellesHusseini, GhalebKherbeck, LauraPitt, William G.Christensen, Douglas A.Velluto, DianaFolated MicellesKinetic Models70-kHz UltrasoundPluronic P105Drug ReleaseRe-encapsulationTargeted Drug DeliveryTo minimize the adverse side effects of conventional chemotherapy, a targeted micellar drug carrier was investigated that retains hydrophobic drugs in its core and then releases the drug via ultrasonic activation. This paper compares the percent drug release from folated versus non-folated micelles by insonation at 70 kHz and different acoustic power densities. The encapsulated drug is Doxorubicin (Dox). A physical model of zero-order release with first-order re-encapsulation was used to fit the experimental kinetic data. Additionally, the acoustic activation power density and Gibbs free energy were introduced and calculated for folated and non-targeted micelles. The data suggests an important role of inertial cavitation in drug release and the presence of a power density threshold for inertial cavitation.American Scientific Publishers2020-08-27T12:04:23Z2020-08-27T12:04:23Z2015Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfHusseini, G. A., Kherbeck, L., Pitt, W. G., Hubbell, J. A., Christensen, D. A., & Velluto, D. (2015). Kinetics of ultrasonic drug delivery from targeted micelles. Journal of Nanoscience and Nanotechnology, 15(3), 2099–2104. https://doi.org/10.1166/jnn.2015.94981533-4880http://hdl.handle.net/11073/1974010.1166/jnn.2015.9498en_UShttps://doi.org/10.1166/jnn.2015.9498oai:repository.aus.edu:11073/197402024-08-22T12:04:54Z |
| spellingShingle | Kinetics of Ultrasonic Drug Delivery from Targeted Micelles Husseini, Ghaleb Folated Micelles Kinetic Models 70-kHz Ultrasound Pluronic P105 Drug Release Re-encapsulation Targeted Drug Delivery |
| status_str | publishedVersion |
| title | Kinetics of Ultrasonic Drug Delivery from Targeted Micelles |
| title_full | Kinetics of Ultrasonic Drug Delivery from Targeted Micelles |
| title_fullStr | Kinetics of Ultrasonic Drug Delivery from Targeted Micelles |
| title_full_unstemmed | Kinetics of Ultrasonic Drug Delivery from Targeted Micelles |
| title_short | Kinetics of Ultrasonic Drug Delivery from Targeted Micelles |
| title_sort | Kinetics of Ultrasonic Drug Delivery from Targeted Micelles |
| topic | Folated Micelles Kinetic Models 70-kHz Ultrasound Pluronic P105 Drug Release Re-encapsulation Targeted Drug Delivery |
| url | http://hdl.handle.net/11073/19740 |