The use of ultrasound to release chemotherapeutic drugs from micelles and liposomes
Several drug delivery systems have been investigated to reduce the side effects of chemotherapy by encapsulating the therapeutic agent in a nanosized carrier until it reaches the tumor site. Many of these particles are designed to be responsive to the mechanical and thermal perturbations delivered b...
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| Other Authors: | , |
| Format: | article |
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2014
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| Online Access: | http://hdl.handle.net/11073/21302 |
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| _version_ | 1864513436265742336 |
|---|---|
| author | Ahmed, Salma E. |
| author2 | Martins, Ana M. Husseini, Ghaleb |
| author2_role | author author |
| author_facet | Ahmed, Salma E. Martins, Ana M. Husseini, Ghaleb |
| author_role | author |
| dc.creator.none.fl_str_mv | Ahmed, Salma E. Martins, Ana M. Husseini, Ghaleb |
| dc.date.none.fl_str_mv | 2014 2021-01-28T08:04:20Z 2021-01-28T08:04:20Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Salma E. Ahmed, Ana M. Martins & Ghaleb A. Husseini (2015) The use of ultrasound to release chemotherapeutic drugs from micelles and liposomes, Journal of Drug Targeting, 23:1, 16-42, DOI: 10.3109/1061186X.2014.954119 1029-2330 http://hdl.handle.net/11073/21302 10.3109/1061186X.2014.954119 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | Taylor & Francis |
| dc.relation.none.fl_str_mv | https://doi.org/10.3109/1061186X.2014.954119 |
| dc.subject.none.fl_str_mv | Doxorubicin NanoDeliv™ Pluronic® Targeting Ultrasound Drug delivery systems Nanocarriers |
| dc.title.none.fl_str_mv | The use of ultrasound to release chemotherapeutic drugs from micelles and liposomes |
| dc.type.none.fl_str_mv | Peer-Reviewed Postprint info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Several drug delivery systems have been investigated to reduce the side effects of chemotherapy by encapsulating the therapeutic agent in a nanosized carrier until it reaches the tumor site. Many of these particles are designed to be responsive to the mechanical and thermal perturbations delivered by ultrasound. Once the nanoparticle reaches the desired location, ultrasound is applied to release the chemotherapy drug only in the vicinity of the targeted (cancer) site, thus avoiding any detrimental interaction with healthy cells in the body. Studies using liposomes and micelles have shown promising results in this area, as these nanoparticles with simple, yet effective structures, showed high efficiency as drug delivery vehicles both in vitro and in vivo. This article reviews the design and application of two novel nanosized chemotherapeutic carriers (i.e. micelles and liposomes) intended to be actuated by ultrasound. |
| format | article |
| id | aus_b6d19436fc97dddc2bdee9a3cc3f9c48 |
| identifier_str_mv | Salma E. Ahmed, Ana M. Martins & Ghaleb A. Husseini (2015) The use of ultrasound to release chemotherapeutic drugs from micelles and liposomes, Journal of Drug Targeting, 23:1, 16-42, DOI: 10.3109/1061186X.2014.954119 1029-2330 10.3109/1061186X.2014.954119 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/21302 |
| publishDate | 2014 |
| publisher.none.fl_str_mv | Taylor & Francis |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | The use of ultrasound to release chemotherapeutic drugs from micelles and liposomesAhmed, Salma E.Martins, Ana M.Husseini, GhalebDoxorubicinNanoDeliv™Pluronic®TargetingUltrasoundDrug delivery systemsNanocarriersSeveral drug delivery systems have been investigated to reduce the side effects of chemotherapy by encapsulating the therapeutic agent in a nanosized carrier until it reaches the tumor site. Many of these particles are designed to be responsive to the mechanical and thermal perturbations delivered by ultrasound. Once the nanoparticle reaches the desired location, ultrasound is applied to release the chemotherapy drug only in the vicinity of the targeted (cancer) site, thus avoiding any detrimental interaction with healthy cells in the body. Studies using liposomes and micelles have shown promising results in this area, as these nanoparticles with simple, yet effective structures, showed high efficiency as drug delivery vehicles both in vitro and in vivo. This article reviews the design and application of two novel nanosized chemotherapeutic carriers (i.e. micelles and liposomes) intended to be actuated by ultrasound.Taylor & Francis2021-01-28T08:04:20Z2021-01-28T08:04:20Z2014Peer-ReviewedPostprintinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfSalma E. Ahmed, Ana M. Martins & Ghaleb A. Husseini (2015) The use of ultrasound to release chemotherapeutic drugs from micelles and liposomes, Journal of Drug Targeting, 23:1, 16-42, DOI: 10.3109/1061186X.2014.9541191029-2330http://hdl.handle.net/11073/2130210.3109/1061186X.2014.954119en_UShttps://doi.org/10.3109/1061186X.2014.954119oai:repository.aus.edu:11073/213022024-08-22T12:05:16Z |
| spellingShingle | The use of ultrasound to release chemotherapeutic drugs from micelles and liposomes Ahmed, Salma E. Doxorubicin NanoDeliv™ Pluronic® Targeting Ultrasound Drug delivery systems Nanocarriers |
| status_str | publishedVersion |
| title | The use of ultrasound to release chemotherapeutic drugs from micelles and liposomes |
| title_full | The use of ultrasound to release chemotherapeutic drugs from micelles and liposomes |
| title_fullStr | The use of ultrasound to release chemotherapeutic drugs from micelles and liposomes |
| title_full_unstemmed | The use of ultrasound to release chemotherapeutic drugs from micelles and liposomes |
| title_short | The use of ultrasound to release chemotherapeutic drugs from micelles and liposomes |
| title_sort | The use of ultrasound to release chemotherapeutic drugs from micelles and liposomes |
| topic | Doxorubicin NanoDeliv™ Pluronic® Targeting Ultrasound Drug delivery systems Nanocarriers |
| url | http://hdl.handle.net/11073/21302 |