Microwave-Responsive Metal-Organic Frameworks (MOFs) for Enhanced In Vitro Controlled Release of Doxorubicin
Metal-organic frameworks (MOFs) are excellent candidates for a range of applications because of their numerous advantages, such as high surface area, porosity, and thermal and chemical stability. In this study, microwave (MW) irradiation is used as a novel stimulus in vitro controlled release of Dox...
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| التنسيق: | article |
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2024
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| الوصول للمادة أونلاين: | https://hdl.handle.net/11073/25557 |
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| _version_ | 1864513443796615168 |
|---|---|
| author | Fatima, Syeda Fiza |
| author2 | Sabouni, Rana Husseini, Ghaleb Paul, Vinod Gomaa, Hassan Radha, Remya |
| author2_role | author author author author author |
| author_facet | Fatima, Syeda Fiza Sabouni, Rana Husseini, Ghaleb Paul, Vinod Gomaa, Hassan Radha, Remya |
| author_role | author |
| dc.creator.none.fl_str_mv | Fatima, Syeda Fiza Sabouni, Rana Husseini, Ghaleb Paul, Vinod Gomaa, Hassan Radha, Remya |
| dc.date.none.fl_str_mv | 2024-07-03T05:17:39Z 2024-07-03T05:17:39Z 2024 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Fatima, S.F.; Sabouni, R.; Husseini, G.; Paul, V.; Gomaa, H.; Radha, R. Microwave-Responsive Metal-Organic Frameworks (MOFs) for Enhanced In Vitro Controlled Release of Doxorubicin. Nanomaterials 2024, 14, 1081. https://doi.org/10.3390/nano14131081 2079-4991 https://hdl.handle.net/11073/25557 10.3390/nano14131081 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | MDPI |
| dc.relation.none.fl_str_mv | https://doi.org/10.3390/nano14131081 |
| dc.subject.none.fl_str_mv | Metal–organic frameworks MOFs in drug delivery MOF synthesis techniques MOF characterization Drug delivery MOFs Cancer Doxorubicin Microwave |
| dc.title.none.fl_str_mv | Microwave-Responsive Metal-Organic Frameworks (MOFs) for Enhanced In Vitro Controlled Release of Doxorubicin |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Metal-organic frameworks (MOFs) are excellent candidates for a range of applications because of their numerous advantages, such as high surface area, porosity, and thermal and chemical stability. In this study, microwave (MW) irradiation is used as a novel stimulus in vitro controlled release of Doxorubicin (DOX) from two MOFs, namely Fe-BTC and MIL-53(Al), to enhance drug delivery in cancer therapy. DOX was encapsulated into Fe-BTC and MIL-53(Al) with drug-loading efficiencies of up to 67% for Fe-BTC and 40% for MIL-53(Al). Several characterization tests, including XRD, FTIR, TGA, BET, FE-SEM, and EDX, confirmed both MOF samples’ drug-loading and -release mechanisms. Fe-BTC exhibited a substantial improvement in drug-release efficiency (54%) when exposed to microwave irradiation at pH 7.4 for 50 min, whereas 11% was achieved without the external modality. A similar result was observed at pH 5.3; however, in both cases, the release efficiencies were substantially higher with microwave exposure (40%) than without (6%). In contrast, MIL-53(Al) exhibited greater sensitivity to pH, displaying a higher release rate (66%) after 38 min at pH 5.3 compared to 55% after 50 min at pH 7.4 when subjected to microwave irradiation. These results highlight the potential of both MOFs as highly heat-responsive to thermal stimuli. The results of the MTT assay demonstrated the cell viability across different concentrations of the MOFs after two days of incubation. This suggests that MOFs hold promise as potential candidates for tumor targeting. Additionally, the fact that the cells maintained their viability at different durations of microwave exposure confirms that the latter is a safe modality for triggering drug release from MOFs. |
| format | article |
| id | aus_bbd1c88960b66e82d69c48a56bccc116 |
| identifier_str_mv | Fatima, S.F.; Sabouni, R.; Husseini, G.; Paul, V.; Gomaa, H.; Radha, R. Microwave-Responsive Metal-Organic Frameworks (MOFs) for Enhanced In Vitro Controlled Release of Doxorubicin. Nanomaterials 2024, 14, 1081. https://doi.org/10.3390/nano14131081 2079-4991 10.3390/nano14131081 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/25557 |
| publishDate | 2024 |
| publisher.none.fl_str_mv | MDPI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Microwave-Responsive Metal-Organic Frameworks (MOFs) for Enhanced In Vitro Controlled Release of DoxorubicinFatima, Syeda FizaSabouni, RanaHusseini, GhalebPaul, VinodGomaa, HassanRadha, RemyaMetal–organic frameworksMOFs in drug deliveryMOF synthesis techniquesMOF characterizationDrug deliveryMOFsCancerDoxorubicinMicrowaveMetal-organic frameworks (MOFs) are excellent candidates for a range of applications because of their numerous advantages, such as high surface area, porosity, and thermal and chemical stability. In this study, microwave (MW) irradiation is used as a novel stimulus in vitro controlled release of Doxorubicin (DOX) from two MOFs, namely Fe-BTC and MIL-53(Al), to enhance drug delivery in cancer therapy. DOX was encapsulated into Fe-BTC and MIL-53(Al) with drug-loading efficiencies of up to 67% for Fe-BTC and 40% for MIL-53(Al). Several characterization tests, including XRD, FTIR, TGA, BET, FE-SEM, and EDX, confirmed both MOF samples’ drug-loading and -release mechanisms. Fe-BTC exhibited a substantial improvement in drug-release efficiency (54%) when exposed to microwave irradiation at pH 7.4 for 50 min, whereas 11% was achieved without the external modality. A similar result was observed at pH 5.3; however, in both cases, the release efficiencies were substantially higher with microwave exposure (40%) than without (6%). In contrast, MIL-53(Al) exhibited greater sensitivity to pH, displaying a higher release rate (66%) after 38 min at pH 5.3 compared to 55% after 50 min at pH 7.4 when subjected to microwave irradiation. These results highlight the potential of both MOFs as highly heat-responsive to thermal stimuli. The results of the MTT assay demonstrated the cell viability across different concentrations of the MOFs after two days of incubation. This suggests that MOFs hold promise as potential candidates for tumor targeting. Additionally, the fact that the cells maintained their viability at different durations of microwave exposure confirms that the latter is a safe modality for triggering drug release from MOFs.American University of SharjahNatural Sciences and Engineering Research Council of Canada (NSERC)MDPI2024-07-03T05:17:39Z2024-07-03T05:17:39Z2024Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfFatima, S.F.; Sabouni, R.; Husseini, G.; Paul, V.; Gomaa, H.; Radha, R. Microwave-Responsive Metal-Organic Frameworks (MOFs) for Enhanced In Vitro Controlled Release of Doxorubicin. Nanomaterials 2024, 14, 1081. https://doi.org/10.3390/nano141310812079-4991https://hdl.handle.net/11073/2555710.3390/nano14131081en_UShttps://doi.org/10.3390/nano14131081oai:repository.aus.edu:11073/255572024-10-16T10:18:15Z |
| spellingShingle | Microwave-Responsive Metal-Organic Frameworks (MOFs) for Enhanced In Vitro Controlled Release of Doxorubicin Fatima, Syeda Fiza Metal–organic frameworks MOFs in drug delivery MOF synthesis techniques MOF characterization Drug delivery MOFs Cancer Doxorubicin Microwave |
| status_str | publishedVersion |
| title | Microwave-Responsive Metal-Organic Frameworks (MOFs) for Enhanced In Vitro Controlled Release of Doxorubicin |
| title_full | Microwave-Responsive Metal-Organic Frameworks (MOFs) for Enhanced In Vitro Controlled Release of Doxorubicin |
| title_fullStr | Microwave-Responsive Metal-Organic Frameworks (MOFs) for Enhanced In Vitro Controlled Release of Doxorubicin |
| title_full_unstemmed | Microwave-Responsive Metal-Organic Frameworks (MOFs) for Enhanced In Vitro Controlled Release of Doxorubicin |
| title_short | Microwave-Responsive Metal-Organic Frameworks (MOFs) for Enhanced In Vitro Controlled Release of Doxorubicin |
| title_sort | Microwave-Responsive Metal-Organic Frameworks (MOFs) for Enhanced In Vitro Controlled Release of Doxorubicin |
| topic | Metal–organic frameworks MOFs in drug delivery MOF synthesis techniques MOF characterization Drug delivery MOFs Cancer Doxorubicin Microwave |
| url | https://hdl.handle.net/11073/25557 |