Using Artificial Neural Networks and Model Predictive Control to Optimize Acoustically Assisted Doxorubicin Release from Polymeric Micelles
We have been developing a drug delivery system that uses Pluronic P105 micelles to sequester a chemotherapeutic drug - namely, Doxorubicin (Dox) - until it reaches the cancer site. Ultrasound is then applied to release the drug directly to the tumor and in the process minimize the adverse side effec...
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2009
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| Online Access: | http://hdl.handle.net/11073/21343 |
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| _version_ | 1864513437549199360 |
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| author | Husseini, Ghaleb |
| author2 | Mjalli, Farouq Sabri Pitt, William G. Abdel-Jabbar, Nabil |
| author2_role | author author author |
| author_facet | Husseini, Ghaleb Mjalli, Farouq Sabri Pitt, William G. Abdel-Jabbar, Nabil |
| author_role | author |
| dc.creator.none.fl_str_mv | Husseini, Ghaleb Mjalli, Farouq Sabri Pitt, William G. Abdel-Jabbar, Nabil |
| dc.date.none.fl_str_mv | 2009 2021-03-07T06:16:30Z 2021-03-07T06:16:30Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Husseini GA, Mjalli FS, Pitt WG, Abdel-Jabbar NM. Using Artificial Neural Networks and Model Predictive Control to Optimize Acoustically Assisted Doxorubicin Release from Polymeric Micelles. Technology in Cancer Research & Treatment. December 2009:479-488. doi:10.1177/153303460900800609 1533-0346 http://hdl.handle.net/11073/21343 10.1177/153303460900800609 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | SAGE Publications |
| dc.relation.none.fl_str_mv | https://doi.org/10.1177/153303460900800609 |
| dc.subject.none.fl_str_mv | Artificial Neural Network Model Predictive Control Doxorubicin Polymeric Micelles Drug Release Continuous and Pulsed Ultrasound |
| dc.title.none.fl_str_mv | Using Artificial Neural Networks and Model Predictive Control to Optimize Acoustically Assisted Doxorubicin Release from Polymeric Micelles |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | We have been developing a drug delivery system that uses Pluronic P105 micelles to sequester a chemotherapeutic drug - namely, Doxorubicin (Dox) - until it reaches the cancer site. Ultrasound is then applied to release the drug directly to the tumor and in the process minimize the adverse side effects of chemotherapy on non-tumor tissues. Here, we present an artificial neural network (ANN) model that attempts to model the dynamic release of Dox from P105 micelles under different ultrasonic power intensities at two frequencies. The developed ANN model is then utilized to optimize the ultrasound application to achieve a target drug release at the tumor site via an ANN-based model predictive control. The parameters of the controller are then tuned to achieve good reference signal tracking. We were successful in designing and testing a controller capable of adjusting the ultrasound frequency, intensity, and pulse length to sustain constant Dox release. |
| format | article |
| id | aus_be67b689da1dde2804771f7a3e21528e |
| identifier_str_mv | Husseini GA, Mjalli FS, Pitt WG, Abdel-Jabbar NM. Using Artificial Neural Networks and Model Predictive Control to Optimize Acoustically Assisted Doxorubicin Release from Polymeric Micelles. Technology in Cancer Research & Treatment. December 2009:479-488. doi:10.1177/153303460900800609 1533-0346 10.1177/153303460900800609 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/21343 |
| publishDate | 2009 |
| publisher.none.fl_str_mv | SAGE Publications |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Using Artificial Neural Networks and Model Predictive Control to Optimize Acoustically Assisted Doxorubicin Release from Polymeric MicellesHusseini, GhalebMjalli, Farouq SabriPitt, William G.Abdel-Jabbar, NabilArtificial Neural NetworkModel Predictive ControlDoxorubicinPolymeric MicellesDrug ReleaseContinuous and Pulsed UltrasoundWe have been developing a drug delivery system that uses Pluronic P105 micelles to sequester a chemotherapeutic drug - namely, Doxorubicin (Dox) - until it reaches the cancer site. Ultrasound is then applied to release the drug directly to the tumor and in the process minimize the adverse side effects of chemotherapy on non-tumor tissues. Here, we present an artificial neural network (ANN) model that attempts to model the dynamic release of Dox from P105 micelles under different ultrasonic power intensities at two frequencies. The developed ANN model is then utilized to optimize the ultrasound application to achieve a target drug release at the tumor site via an ANN-based model predictive control. The parameters of the controller are then tuned to achieve good reference signal tracking. We were successful in designing and testing a controller capable of adjusting the ultrasound frequency, intensity, and pulse length to sustain constant Dox release.SAGE Publications2021-03-07T06:16:30Z2021-03-07T06:16:30Z2009Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfHusseini GA, Mjalli FS, Pitt WG, Abdel-Jabbar NM. Using Artificial Neural Networks and Model Predictive Control to Optimize Acoustically Assisted Doxorubicin Release from Polymeric Micelles. Technology in Cancer Research & Treatment. December 2009:479-488. doi:10.1177/1533034609008006091533-0346http://hdl.handle.net/11073/2134310.1177/153303460900800609en_UShttps://doi.org/10.1177/153303460900800609oai:repository.aus.edu:11073/213432024-08-22T12:05:35Z |
| spellingShingle | Using Artificial Neural Networks and Model Predictive Control to Optimize Acoustically Assisted Doxorubicin Release from Polymeric Micelles Husseini, Ghaleb Artificial Neural Network Model Predictive Control Doxorubicin Polymeric Micelles Drug Release Continuous and Pulsed Ultrasound |
| status_str | publishedVersion |
| title | Using Artificial Neural Networks and Model Predictive Control to Optimize Acoustically Assisted Doxorubicin Release from Polymeric Micelles |
| title_full | Using Artificial Neural Networks and Model Predictive Control to Optimize Acoustically Assisted Doxorubicin Release from Polymeric Micelles |
| title_fullStr | Using Artificial Neural Networks and Model Predictive Control to Optimize Acoustically Assisted Doxorubicin Release from Polymeric Micelles |
| title_full_unstemmed | Using Artificial Neural Networks and Model Predictive Control to Optimize Acoustically Assisted Doxorubicin Release from Polymeric Micelles |
| title_short | Using Artificial Neural Networks and Model Predictive Control to Optimize Acoustically Assisted Doxorubicin Release from Polymeric Micelles |
| title_sort | Using Artificial Neural Networks and Model Predictive Control to Optimize Acoustically Assisted Doxorubicin Release from Polymeric Micelles |
| topic | Artificial Neural Network Model Predictive Control Doxorubicin Polymeric Micelles Drug Release Continuous and Pulsed Ultrasound |
| url | http://hdl.handle.net/11073/21343 |