Metal–Organic Framework-Based Drug Delivery Systems for Cancer Therapy: A Review
Cancer remains one of the most significant global health challenges, with conventional treatments limited by side effects and resistance to drugs. The unique properties of metal–organic frameworks (MOFs), which offer high surface areas, tunable structures, and biodegradable properties, make them pro...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , , , |
| التنسيق: | article |
| منشور في: |
2026
|
| الموضوعات: | |
| الوصول للمادة أونلاين: | https://hdl.handle.net/11073/33245 |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513431857528832 |
|---|---|
| author | Hatami, Sedigheh |
| author2 | Chahrour, Khaled El Fakhouri, Joelle Mohammed, Fares Sabouni, Rana Husseini, Ghaleb |
| author2_role | author author author author author |
| author_facet | Hatami, Sedigheh Chahrour, Khaled El Fakhouri, Joelle Mohammed, Fares Sabouni, Rana Husseini, Ghaleb |
| author_role | author |
| dc.creator.none.fl_str_mv | Hatami, Sedigheh Chahrour, Khaled El Fakhouri, Joelle Mohammed, Fares Sabouni, Rana Husseini, Ghaleb |
| dc.date.none.fl_str_mv | 2026-03-10T09:13:59Z 2026-03-10T09:13:59Z 2026 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Hatami, S.; Chahrour, K.; El Fakhouri, J.; Mohammed, F.; Sabouni, R.; Husseini, G.A. Metal–Organic Framework-Based Drug Delivery Systems for Cancer Therapy: A Review. Int. J. Mol. Sci. 2026, 27, 1548. https://doi.org/10.3390/ijms27031548 1422-0067 https://hdl.handle.net/11073/33245 10.3390/ijms27031548 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | MDPI |
| dc.relation.none.fl_str_mv | https://doi.org/10.3390/ijms27031548 |
| dc.subject.none.fl_str_mv | Metal–organic framework Cytotoxicity Synthesis method Drug loading |
| dc.title.none.fl_str_mv | Metal–Organic Framework-Based Drug Delivery Systems for Cancer Therapy: A Review |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Cancer remains one of the most significant global health challenges, with conventional treatments limited by side effects and resistance to drugs. The unique properties of metal–organic frameworks (MOFs), which offer high surface areas, tunable structures, and biodegradable properties, make them promising candidates for cancer therapy. This review focuses on MOF-based drug delivery systems for cancer treatment in biomedical applications. This article discusses various synthesis methods, drug-loading strategies, and cytotoxicity considerations. The relationship between the basic chemistry of MOFs and their biomedical applications is elucidated by how each feature directly affects MOF performance in cancer drug delivery. Therefore, this review is a practical and complete guide for researchers working to translate MOFs into effective cancer treatments. Moreover, the role of stimuli-responsive MOFs in cancer therapy is highlighted, along with recent studies demonstrating the effectiveness of MOF-based drug delivery systems. Overall, MOFs offer opportunities for advancing cancer treatment and controlled drug delivery. |
| format | article |
| id | aus_c08606db614fe1e2ccbb99b5f02d5478 |
| identifier_str_mv | Hatami, S.; Chahrour, K.; El Fakhouri, J.; Mohammed, F.; Sabouni, R.; Husseini, G.A. Metal–Organic Framework-Based Drug Delivery Systems for Cancer Therapy: A Review. Int. J. Mol. Sci. 2026, 27, 1548. https://doi.org/10.3390/ijms27031548 1422-0067 10.3390/ijms27031548 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/33245 |
| publishDate | 2026 |
| publisher.none.fl_str_mv | MDPI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Metal–Organic Framework-Based Drug Delivery Systems for Cancer Therapy: A ReviewHatami, SedighehChahrour, KhaledEl Fakhouri, JoelleMohammed, FaresSabouni, RanaHusseini, GhalebMetal–organic frameworkCytotoxicitySynthesis methodDrug loadingCancer remains one of the most significant global health challenges, with conventional treatments limited by side effects and resistance to drugs. The unique properties of metal–organic frameworks (MOFs), which offer high surface areas, tunable structures, and biodegradable properties, make them promising candidates for cancer therapy. This review focuses on MOF-based drug delivery systems for cancer treatment in biomedical applications. This article discusses various synthesis methods, drug-loading strategies, and cytotoxicity considerations. The relationship between the basic chemistry of MOFs and their biomedical applications is elucidated by how each feature directly affects MOF performance in cancer drug delivery. Therefore, this review is a practical and complete guide for researchers working to translate MOFs into effective cancer treatments. Moreover, the role of stimuli-responsive MOFs in cancer therapy is highlighted, along with recent studies demonstrating the effectiveness of MOF-based drug delivery systems. Overall, MOFs offer opportunities for advancing cancer treatment and controlled drug delivery.Dana Gas Endowed Chair for Chemical EngineeringAmerican University of SharjahSheikh Hamdan Award for Medical SciencesFriends of Cancer Patients (FoCP)MDPI2026-03-10T09:13:59Z2026-03-10T09:13:59Z2026Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfHatami, S.; Chahrour, K.; El Fakhouri, J.; Mohammed, F.; Sabouni, R.; Husseini, G.A. Metal–Organic Framework-Based Drug Delivery Systems for Cancer Therapy: A Review. Int. J. Mol. Sci. 2026, 27, 1548. https://doi.org/10.3390/ijms270315481422-0067https://hdl.handle.net/11073/3324510.3390/ijms27031548en_UShttps://doi.org/10.3390/ijms27031548oai:repository.aus.edu:11073/332452026-03-11T05:25:58Z |
| spellingShingle | Metal–Organic Framework-Based Drug Delivery Systems for Cancer Therapy: A Review Hatami, Sedigheh Metal–organic framework Cytotoxicity Synthesis method Drug loading |
| status_str | publishedVersion |
| title | Metal–Organic Framework-Based Drug Delivery Systems for Cancer Therapy: A Review |
| title_full | Metal–Organic Framework-Based Drug Delivery Systems for Cancer Therapy: A Review |
| title_fullStr | Metal–Organic Framework-Based Drug Delivery Systems for Cancer Therapy: A Review |
| title_full_unstemmed | Metal–Organic Framework-Based Drug Delivery Systems for Cancer Therapy: A Review |
| title_short | Metal–Organic Framework-Based Drug Delivery Systems for Cancer Therapy: A Review |
| title_sort | Metal–Organic Framework-Based Drug Delivery Systems for Cancer Therapy: A Review |
| topic | Metal–organic framework Cytotoxicity Synthesis method Drug loading |
| url | https://hdl.handle.net/11073/33245 |