pH-Responsive Nanocarriers in Cancer Therapy
A number of promising nano-sized particles (nanoparticles) have been developed to conquer the limitations of conventional chemotherapy. One of the most promising methods is stimuli-responsive nanoparticles because they enable the safe delivery of the drugs while controlling their release at the tumo...
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2022
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| Online Access: | http://hdl.handle.net/11073/21643 |
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| _version_ | 1864513437169614848 |
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| author | AlSawaftah, Nour Majdi |
| author2 | Awad, Nahid S. Pitt, William G. Husseini, Ghaleb |
| author2_role | author author author |
| author_facet | AlSawaftah, Nour Majdi Awad, Nahid S. Pitt, William G. Husseini, Ghaleb |
| author_role | author |
| dc.creator.none.fl_str_mv | AlSawaftah, Nour Majdi Awad, Nahid S. Pitt, William G. Husseini, Ghaleb |
| dc.date.none.fl_str_mv | 2022-02-28T07:13:06Z 2022-02-28T07:13:06Z 2022 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | AlSawaftah, N.M.; Awad, N.S.; Pitt, W.G.; Husseini, G.A. pH-Responsive Nanocarriers in Cancer Therapy. Polymers 2022, 14, 936. https://doi.org/10.3390/polym14050936 2073-4360 http://hdl.handle.net/11073/21643 10.3390/polym14050936 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | MDPI |
| dc.relation.none.fl_str_mv | https://doi.org/10.3390/polym14050936 |
| dc.subject.none.fl_str_mv | Nanoparticles pH Drug Delivery Cancer |
| dc.title.none.fl_str_mv | pH-Responsive Nanocarriers in Cancer Therapy |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | A number of promising nano-sized particles (nanoparticles) have been developed to conquer the limitations of conventional chemotherapy. One of the most promising methods is stimuli-responsive nanoparticles because they enable the safe delivery of the drugs while controlling their release at the tumor sites. Different intrinsic and extrinsic stimuli can be used to trigger drug release such as temperature, redox, ultrasound, magnetic field, and pH. The intracellular pH of solid tumors is maintained below the extracellular pH. Thus, pH-sensitive nanoparticles are highly efficient in delivering drugs to tumors compared to conventional nanoparticles. This review provides a survey of the different strategies used to develop pH-sensitive nanoparticles used in cancer therapy. |
| format | article |
| id | aus_c7023bfe3b648237dbf7b22047d39b36 |
| identifier_str_mv | AlSawaftah, N.M.; Awad, N.S.; Pitt, W.G.; Husseini, G.A. pH-Responsive Nanocarriers in Cancer Therapy. Polymers 2022, 14, 936. https://doi.org/10.3390/polym14050936 2073-4360 10.3390/polym14050936 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/21643 |
| publishDate | 2022 |
| publisher.none.fl_str_mv | MDPI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | pH-Responsive Nanocarriers in Cancer TherapyAlSawaftah, Nour MajdiAwad, Nahid S.Pitt, William G.Husseini, GhalebNanoparticlespHDrug DeliveryCancerA number of promising nano-sized particles (nanoparticles) have been developed to conquer the limitations of conventional chemotherapy. One of the most promising methods is stimuli-responsive nanoparticles because they enable the safe delivery of the drugs while controlling their release at the tumor sites. Different intrinsic and extrinsic stimuli can be used to trigger drug release such as temperature, redox, ultrasound, magnetic field, and pH. The intracellular pH of solid tumors is maintained below the extracellular pH. Thus, pH-sensitive nanoparticles are highly efficient in delivering drugs to tumors compared to conventional nanoparticles. This review provides a survey of the different strategies used to develop pH-sensitive nanoparticles used in cancer therapy.Dana Gas Endowed Chair for Chemical EngineeringAmerican University of SharjahSheikh Hamdan Award for Medical SciencesFriends of Cancer PatientMDPI2022-02-28T07:13:06Z2022-02-28T07:13:06Z2022Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfAlSawaftah, N.M.; Awad, N.S.; Pitt, W.G.; Husseini, G.A. pH-Responsive Nanocarriers in Cancer Therapy. Polymers 2022, 14, 936. https://doi.org/10.3390/polym140509362073-4360http://hdl.handle.net/11073/2164310.3390/polym14050936en_UShttps://doi.org/10.3390/polym14050936oai:repository.aus.edu:11073/216432024-08-22T12:04:31Z |
| spellingShingle | pH-Responsive Nanocarriers in Cancer Therapy AlSawaftah, Nour Majdi Nanoparticles pH Drug Delivery Cancer |
| status_str | publishedVersion |
| title | pH-Responsive Nanocarriers in Cancer Therapy |
| title_full | pH-Responsive Nanocarriers in Cancer Therapy |
| title_fullStr | pH-Responsive Nanocarriers in Cancer Therapy |
| title_full_unstemmed | pH-Responsive Nanocarriers in Cancer Therapy |
| title_short | pH-Responsive Nanocarriers in Cancer Therapy |
| title_sort | pH-Responsive Nanocarriers in Cancer Therapy |
| topic | Nanoparticles pH Drug Delivery Cancer |
| url | http://hdl.handle.net/11073/21643 |