Modeling of the In Vitro Release Kinetics of Sonosensitive Targeted Liposomes
Targeted liposomes triggered by ultrasound are a promising drug delivery system as they potentially improve the clinical outcomes of chemotherapy while reducing associated side effects. In this work, a comprehensive model fitting was performed for a large dataset of liposomal release profiles with s...
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2022
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| Online Access: | http://hdl.handle.net/11073/25088 |
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| _version_ | 1864513443270230016 |
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| author | Almajed, Zeyad Mohamed |
| author2 | Salkho, Najla Sulieman, Hana Husseini, Ghaleb |
| author2_role | author author author |
| author_facet | Almajed, Zeyad Mohamed Salkho, Najla Sulieman, Hana Husseini, Ghaleb |
| author_role | author |
| dc.creator.none.fl_str_mv | Almajed, Zeyad Mohamed Salkho, Najla Sulieman, Hana Husseini, Ghaleb |
| dc.date.none.fl_str_mv | 2022-12-07T10:22:53Z 2022-12-07T10:22:53Z 2022-12-05 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | AlMajed, Z.; Salkho, N.M.; Sulieman, H.; Husseini, G.A. Modeling of the In Vitro Release Kinetics of Sonosensitive Targeted Liposomes. Biomedicines 2022, 10, 3139. https://doi.org/10.3390/biomedicines10123139 2227-9059 http://hdl.handle.net/11073/25088 10.3390/biomedicines10123139 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | MDPI |
| dc.relation.none.fl_str_mv | https://doi.org/10.3390/biomedicines10123139 |
| dc.subject.none.fl_str_mv | Drug delivery systems Cancer treatment Liposomes Ligand targeting Ultrasound Drug release Kinetic model fitting |
| dc.title.none.fl_str_mv | Modeling of the In Vitro Release Kinetics of Sonosensitive Targeted Liposomes |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Targeted liposomes triggered by ultrasound are a promising drug delivery system as they potentially improve the clinical outcomes of chemotherapy while reducing associated side effects. In this work, a comprehensive model fitting was performed for a large dataset of liposomal release profiles with seven targeting moieties (albumin, cRGD, estrone, hyaluronic acid, Herceptin, lactobionic acid, and transferrin) in addition to the control liposomes under ultrasound release protocols. Two levels of ultrasound frequencies were tested: low frequency (20 kHz) at 6.2, 9, and 10 mW/cm2 as well as high frequencies (1.07 MHz and 3 MHz) at 10.5 and 173 W/cm2. At a low frequency, Hixson–Crowell, Korsmeyer–Peppas, Gompertz, Weibull, and Lu–Hagen showed good fits to our release profiles at all three power densities. At high frequencies, the former three models reflected the best fit. These models will aid in predicting drug release profiles for future in vitro studies. |
| format | article |
| id | aus_cb01761a2b9f7d09d53ed51ba318859f |
| identifier_str_mv | AlMajed, Z.; Salkho, N.M.; Sulieman, H.; Husseini, G.A. Modeling of the In Vitro Release Kinetics of Sonosensitive Targeted Liposomes. Biomedicines 2022, 10, 3139. https://doi.org/10.3390/biomedicines10123139 2227-9059 10.3390/biomedicines10123139 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/25088 |
| publishDate | 2022 |
| publisher.none.fl_str_mv | MDPI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Modeling of the In Vitro Release Kinetics of Sonosensitive Targeted LiposomesAlmajed, Zeyad MohamedSalkho, NajlaSulieman, HanaHusseini, GhalebDrug delivery systemsCancer treatmentLiposomesLigand targetingUltrasoundDrug releaseKinetic model fittingTargeted liposomes triggered by ultrasound are a promising drug delivery system as they potentially improve the clinical outcomes of chemotherapy while reducing associated side effects. In this work, a comprehensive model fitting was performed for a large dataset of liposomal release profiles with seven targeting moieties (albumin, cRGD, estrone, hyaluronic acid, Herceptin, lactobionic acid, and transferrin) in addition to the control liposomes under ultrasound release protocols. Two levels of ultrasound frequencies were tested: low frequency (20 kHz) at 6.2, 9, and 10 mW/cm2 as well as high frequencies (1.07 MHz and 3 MHz) at 10.5 and 173 W/cm2. At a low frequency, Hixson–Crowell, Korsmeyer–Peppas, Gompertz, Weibull, and Lu–Hagen showed good fits to our release profiles at all three power densities. At high frequencies, the former three models reflected the best fit. These models will aid in predicting drug release profiles for future in vitro studies.Dana Gas Endowed Chair for Chemical EngineeringAmerican University of SharjahSheikh Hamdan Award for Medical SciencesFriends of Cancer PatientsMDPI2022-12-07T10:22:53Z2022-12-07T10:22:53Z2022-12-05Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfAlMajed, Z.; Salkho, N.M.; Sulieman, H.; Husseini, G.A. Modeling of the In Vitro Release Kinetics of Sonosensitive Targeted Liposomes. Biomedicines 2022, 10, 3139. https://doi.org/10.3390/biomedicines101231392227-9059http://hdl.handle.net/11073/2508810.3390/biomedicines10123139en_UShttps://doi.org/10.3390/biomedicines10123139oai:repository.aus.edu:11073/250882024-08-22T12:05:46Z |
| spellingShingle | Modeling of the In Vitro Release Kinetics of Sonosensitive Targeted Liposomes Almajed, Zeyad Mohamed Drug delivery systems Cancer treatment Liposomes Ligand targeting Ultrasound Drug release Kinetic model fitting |
| status_str | publishedVersion |
| title | Modeling of the In Vitro Release Kinetics of Sonosensitive Targeted Liposomes |
| title_full | Modeling of the In Vitro Release Kinetics of Sonosensitive Targeted Liposomes |
| title_fullStr | Modeling of the In Vitro Release Kinetics of Sonosensitive Targeted Liposomes |
| title_full_unstemmed | Modeling of the In Vitro Release Kinetics of Sonosensitive Targeted Liposomes |
| title_short | Modeling of the In Vitro Release Kinetics of Sonosensitive Targeted Liposomes |
| title_sort | Modeling of the In Vitro Release Kinetics of Sonosensitive Targeted Liposomes |
| topic | Drug delivery systems Cancer treatment Liposomes Ligand targeting Ultrasound Drug release Kinetic model fitting |
| url | http://hdl.handle.net/11073/25088 |