Health benefits of sesamin on cardiovascular disease and its associated risk factors

Sesamin, a major lignin isolated from sesame (Sesamum indicum) seeds and sesame oil, is known to possess antioxidant and anti-inflammatory properties. Several studies have revealed that oxidative stress and inflammation play a major role in a variety of cardiovascular diseases (CVDs). This comprehen...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلف الرئيسي: Dalibalta, Sarah (author)
مؤلفون آخرون: Majdalawieh, Amin (author), Manjikian, Herak (author)
التنسيق: article
منشور في: 2020
الموضوعات:
الوصول للمادة أونلاين:http://hdl.handle.net/11073/25044
الوسوم: إضافة وسم
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author Dalibalta, Sarah
author2 Majdalawieh, Amin
Manjikian, Herak
author2_role author
author
author_facet Dalibalta, Sarah
Majdalawieh, Amin
Manjikian, Herak
author_role author
dc.creator.none.fl_str_mv Dalibalta, Sarah
Majdalawieh, Amin
Manjikian, Herak
dc.date.none.fl_str_mv 2020
2022-10-25T05:33:19Z
2022-10-25T05:33:19Z
dc.format.none.fl_str_mv application/pdf
dc.identifier.none.fl_str_mv Dalibalta S, Majdalawieh A, Manjikian H. (2020) Health benefits of sesamin on cardiovascular disease and its associated risk factors. Saudi Pharmaceutical Journal 28(10):1276-1289. https://doi.org/10.1016/j.jsps.2020.08.018.
1319-0164
http://hdl.handle.net/11073/25044
10.1016/j.jsps.2020.08.018
dc.language.none.fl_str_mv en_US
dc.publisher.none.fl_str_mv Elsevier
dc.relation.none.fl_str_mv https://doi.org/10.1016/j.jsps.2020.08.018
dc.subject.none.fl_str_mv Sesamin
CVD
Cardiovascular diseases (CVDs)
Hypertension
Atherosclerosis
Thrombosis
Diabetes
Obesity
dc.title.none.fl_str_mv Health benefits of sesamin on cardiovascular disease and its associated risk factors
dc.type.none.fl_str_mv Peer-Reviewed
Published version
info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/article
description Sesamin, a major lignin isolated from sesame (Sesamum indicum) seeds and sesame oil, is known to possess antioxidant and anti-inflammatory properties. Several studies have revealed that oxidative stress and inflammation play a major role in a variety of cardiovascular diseases (CVDs). This comprehensive review summarizes the evidence on the effects of sesamin on CVD and its risk factors, principally due to its antioxidant properties. Specifically, this review highlights the mechanisms underlying the anti-hypertensive, anti-atherogenic, anti-thrombotic, anti-diabetic, and anti-obesity, lipolytic effects of sesamin both in vivo and in vitro, and identifies the signaling pathways targeted by sesamin and its metabolites. The data indicates that RAS/MAPK, PI3K/AKT, ERK1/2, p38, p53, IL-6, TNFα, and NF-κB signaling networks are all involved in moderating the various effects of sesamin on CVD and its risk factors. In conclusion, the experimental evidence suggesting that sesamin can reduce CVD risk is convincing. Thus, sesamin can be potentially useful as an adjuvant therapeutic agent to combat CVD and its multitude of risk factors.
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identifier_str_mv Dalibalta S, Majdalawieh A, Manjikian H. (2020) Health benefits of sesamin on cardiovascular disease and its associated risk factors. Saudi Pharmaceutical Journal 28(10):1276-1289. https://doi.org/10.1016/j.jsps.2020.08.018.
1319-0164
10.1016/j.jsps.2020.08.018
language_invalid_str_mv en_US
network_acronym_str aus
network_name_str aus
oai_identifier_str oai:repository.aus.edu:11073/25044
publishDate 2020
publisher.none.fl_str_mv Elsevier
repository.mail.fl_str_mv
repository.name.fl_str_mv
repository_id_str
spelling Health benefits of sesamin on cardiovascular disease and its associated risk factorsDalibalta, SarahMajdalawieh, AminManjikian, HerakSesaminCVDCardiovascular diseases (CVDs)HypertensionAtherosclerosisThrombosisDiabetesObesitySesamin, a major lignin isolated from sesame (Sesamum indicum) seeds and sesame oil, is known to possess antioxidant and anti-inflammatory properties. Several studies have revealed that oxidative stress and inflammation play a major role in a variety of cardiovascular diseases (CVDs). This comprehensive review summarizes the evidence on the effects of sesamin on CVD and its risk factors, principally due to its antioxidant properties. Specifically, this review highlights the mechanisms underlying the anti-hypertensive, anti-atherogenic, anti-thrombotic, anti-diabetic, and anti-obesity, lipolytic effects of sesamin both in vivo and in vitro, and identifies the signaling pathways targeted by sesamin and its metabolites. The data indicates that RAS/MAPK, PI3K/AKT, ERK1/2, p38, p53, IL-6, TNFα, and NF-κB signaling networks are all involved in moderating the various effects of sesamin on CVD and its risk factors. In conclusion, the experimental evidence suggesting that sesamin can reduce CVD risk is convincing. Thus, sesamin can be potentially useful as an adjuvant therapeutic agent to combat CVD and its multitude of risk factors.American University of SharjahElsevier2022-10-25T05:33:19Z2022-10-25T05:33:19Z2020Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfDalibalta S, Majdalawieh A, Manjikian H. (2020) Health benefits of sesamin on cardiovascular disease and its associated risk factors. Saudi Pharmaceutical Journal 28(10):1276-1289. https://doi.org/10.1016/j.jsps.2020.08.018.1319-0164http://hdl.handle.net/11073/2504410.1016/j.jsps.2020.08.018en_UShttps://doi.org/10.1016/j.jsps.2020.08.018oai:repository.aus.edu:11073/250442024-08-22T11:59:27Z
spellingShingle Health benefits of sesamin on cardiovascular disease and its associated risk factors
Dalibalta, Sarah
Sesamin
CVD
Cardiovascular diseases (CVDs)
Hypertension
Atherosclerosis
Thrombosis
Diabetes
Obesity
status_str publishedVersion
title Health benefits of sesamin on cardiovascular disease and its associated risk factors
title_full Health benefits of sesamin on cardiovascular disease and its associated risk factors
title_fullStr Health benefits of sesamin on cardiovascular disease and its associated risk factors
title_full_unstemmed Health benefits of sesamin on cardiovascular disease and its associated risk factors
title_short Health benefits of sesamin on cardiovascular disease and its associated risk factors
title_sort Health benefits of sesamin on cardiovascular disease and its associated risk factors
topic Sesamin
CVD
Cardiovascular diseases (CVDs)
Hypertension
Atherosclerosis
Thrombosis
Diabetes
Obesity
url http://hdl.handle.net/11073/25044