Micelles and nanoparticles for ultrasonic drug and gene delivery
Drug delivery research employing micelles and nanoparticles has expanded in recent years. Of particular interest is the use of these nanovehicles that deliver high concentrations of cytotoxic drugs to diseased tissues selectively, thus reducing the agent's side effects on the rest of the body....
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | |
| التنسيق: | article |
| منشور في: |
2008
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/11073/21274 |
| الوسوم: |
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| _version_ | 1864513444231774208 |
|---|---|
| author | Husseini, Ghaleb |
| author2 | Pitt, William G. |
| author2_role | author |
| author_facet | Husseini, Ghaleb Pitt, William G. |
| author_role | author |
| dc.creator.none.fl_str_mv | Husseini, Ghaleb Pitt, William G. |
| dc.date.none.fl_str_mv | 2008 2021-01-14T08:12:26Z 2021-01-14T08:12:26Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Ghaleb A. Husseini, William G. Pitt, Micelles and nanoparticles for ultrasonic drug and gene delivery, Advanced Drug Delivery Reviews, Volume 60, Issue 10, 2008, Pages 1137-1152, ISSN 0169-409X, https://doi.org/10.1016/j.addr.2008.03.008. 0169-409X http://hdl.handle.net/11073/21274 10.1016/j.addr.2008.03.008 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.relation.none.fl_str_mv | https://doi.org/10.1016/j.addr.2008.03.008 |
| dc.subject.none.fl_str_mv | Targeted delivery Polymeric micelles Thermo-responsive polymers Ultrasound Non-viral gene transfection Drug delivery Nanoemulsions Solid nanoparticles Liposomes |
| dc.title.none.fl_str_mv | Micelles and nanoparticles for ultrasonic drug and gene delivery |
| dc.type.none.fl_str_mv | Peer-Reviewed Postprint info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Drug delivery research employing micelles and nanoparticles has expanded in recent years. Of particular interest is the use of these nanovehicles that deliver high concentrations of cytotoxic drugs to diseased tissues selectively, thus reducing the agent's side effects on the rest of the body. Ultrasound, traditionally used in diagnostic medicine, is finding a place in drug delivery in connection with these nanoparticles. In addition to their non-invasive nature and the fact that they can be focused on targeted tissues, acoustic waves have been credited with releasing pharmacological agents from nanocarriers, as well as rendering cell membranes more permeable. In this article, we summarize new technologies that combine the use of nanoparticles with acoustic power both in drug and gene delivery. Ultrasonic drug delivery from micelles usually employs polyether block copolymers and has been found effective in vivo for treating tumors. Ultrasound releases drug from micelles, most probably via shear stress and shock waves from the collapse of cavitation bubbles. Liquid emulsions and solid nanoparticles are used with ultrasound to deliver genes in vitro and in vivo. The small packaging allows nanoparticles to extravasate into tumor tissues. Ultrasonic drug and gene delivery from nanocarriers has tremendous potential because of the wide variety of drugs and genes that could be delivered to targeted tissues by fairly non-invasive means. |
| format | article |
| id | aus_d04e1cde5d7427fe68c43a8ca62f1bf9 |
| identifier_str_mv | Ghaleb A. Husseini, William G. Pitt, Micelles and nanoparticles for ultrasonic drug and gene delivery, Advanced Drug Delivery Reviews, Volume 60, Issue 10, 2008, Pages 1137-1152, ISSN 0169-409X, https://doi.org/10.1016/j.addr.2008.03.008. 0169-409X 10.1016/j.addr.2008.03.008 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/21274 |
| publishDate | 2008 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
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| spelling | Micelles and nanoparticles for ultrasonic drug and gene deliveryHusseini, GhalebPitt, William G.Targeted deliveryPolymeric micellesThermo-responsive polymersUltrasoundNon-viral gene transfectionDrug deliveryNanoemulsionsSolid nanoparticlesLiposomesDrug delivery research employing micelles and nanoparticles has expanded in recent years. Of particular interest is the use of these nanovehicles that deliver high concentrations of cytotoxic drugs to diseased tissues selectively, thus reducing the agent's side effects on the rest of the body. Ultrasound, traditionally used in diagnostic medicine, is finding a place in drug delivery in connection with these nanoparticles. In addition to their non-invasive nature and the fact that they can be focused on targeted tissues, acoustic waves have been credited with releasing pharmacological agents from nanocarriers, as well as rendering cell membranes more permeable. In this article, we summarize new technologies that combine the use of nanoparticles with acoustic power both in drug and gene delivery. Ultrasonic drug delivery from micelles usually employs polyether block copolymers and has been found effective in vivo for treating tumors. Ultrasound releases drug from micelles, most probably via shear stress and shock waves from the collapse of cavitation bubbles. Liquid emulsions and solid nanoparticles are used with ultrasound to deliver genes in vitro and in vivo. The small packaging allows nanoparticles to extravasate into tumor tissues. Ultrasonic drug and gene delivery from nanocarriers has tremendous potential because of the wide variety of drugs and genes that could be delivered to targeted tissues by fairly non-invasive means.Elsevier2021-01-14T08:12:26Z2021-01-14T08:12:26Z2008Peer-ReviewedPostprintinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfGhaleb A. Husseini, William G. Pitt, Micelles and nanoparticles for ultrasonic drug and gene delivery, Advanced Drug Delivery Reviews, Volume 60, Issue 10, 2008, Pages 1137-1152, ISSN 0169-409X, https://doi.org/10.1016/j.addr.2008.03.008.0169-409Xhttp://hdl.handle.net/11073/2127410.1016/j.addr.2008.03.008en_UShttps://doi.org/10.1016/j.addr.2008.03.008oai:repository.aus.edu:11073/212742024-08-22T12:06:18Z |
| spellingShingle | Micelles and nanoparticles for ultrasonic drug and gene delivery Husseini, Ghaleb Targeted delivery Polymeric micelles Thermo-responsive polymers Ultrasound Non-viral gene transfection Drug delivery Nanoemulsions Solid nanoparticles Liposomes |
| status_str | publishedVersion |
| title | Micelles and nanoparticles for ultrasonic drug and gene delivery |
| title_full | Micelles and nanoparticles for ultrasonic drug and gene delivery |
| title_fullStr | Micelles and nanoparticles for ultrasonic drug and gene delivery |
| title_full_unstemmed | Micelles and nanoparticles for ultrasonic drug and gene delivery |
| title_short | Micelles and nanoparticles for ultrasonic drug and gene delivery |
| title_sort | Micelles and nanoparticles for ultrasonic drug and gene delivery |
| topic | Targeted delivery Polymeric micelles Thermo-responsive polymers Ultrasound Non-viral gene transfection Drug delivery Nanoemulsions Solid nanoparticles Liposomes |
| url | http://hdl.handle.net/11073/21274 |