Potential immunomodulatory role of sesamin in combating immune dysregulation associated with COVID-19
The ongoing outbreak of novel coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused an unprecedented global health crisis. Development of a cure for this devastating disease is currently at full speed, with several vaccines against CO...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , |
| التنسيق: | article |
| منشور في: |
2021
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/11073/25042 |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513438342971392 |
|---|---|
| author | Majdalawieh, Amin |
| author2 | Yousef, Sarah M. Abu-Yousef, Imad |
| author2_role | author author |
| author_facet | Majdalawieh, Amin Yousef, Sarah M. Abu-Yousef, Imad |
| author_role | author |
| dc.creator.none.fl_str_mv | Majdalawieh, Amin Yousef, Sarah M. Abu-Yousef, Imad |
| dc.date.none.fl_str_mv | 2021 2022-10-24T06:21:06Z 2022-10-24T06:21:06Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Majdalawieh AF, Yousef SM, Abu-Yousef IA. Potential immunomodulatory role of sesamin in combating immune dysregulation associated with COVID-19. Asian Pac J Trop Biomed 2021; 11(10): 421-428. https://www.apjtb.org/text.asp?2021/11/10/421/326096 2221-1691 http://hdl.handle.net/11073/25042 10.4103/2221-1691.326096 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | Medknow Publications |
| dc.relation.none.fl_str_mv | https://www.apjtb.org/text.asp?2021/11/10/421/326096 |
| dc.subject.none.fl_str_mv | Sesamin SARS-CoV-2 COVID-19 Immunomodulation Anti-inflammatory Cytokine storm Th1/Th2 balance |
| dc.title.none.fl_str_mv | Potential immunomodulatory role of sesamin in combating immune dysregulation associated with COVID-19 |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | The ongoing outbreak of novel coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused an unprecedented global health crisis. Development of a cure for this devastating disease is currently at full speed, with several vaccines against COVID-19 already authorized and administered. Currently, demand for these vaccines far exceeds supply. As such, boosting immunity represents a viable route to halt the rapid spread of SARS-CoV-2 and limit fatalities until vaccines become more readily and widely available. The use of phytochemicals appears to be a promising panacea. Sesamin, a lignan isolated from Sesamum indicum seeds, is known for its potent pharmacological properties, and is therefore hypothesized as a potential candidate in the therapeutic regimen against COVID-19. Herein, we highlight the confirmed therapeutic anti-inflammatory and immune-modulatory potential of sesamin against myriads of respiratory disorders, and tentatively suggest that sesamin may exert similar potent effects against COVID-19. Precisely, we speculate that sesamin may help alleviate COVID-19 via restoring Th1/Th2 balance and preventing inflammation and cytokine storm development. Additionally, we further support the promising role of sesamin against COVID-19 by underscoring the direct evidence, which suggests that sesamin may demonstrate promising inhibitory potential against three important SARS-CoV-2 targets, namely main protease, spike protein, and angiotensin-converting enzyme 2 receptor. Although preliminary, there is ample evidence to propose sesamin as a potential phytotherapeutic and prophylactic candidate against COVID-19. Further in vitro, in vivo, and preclinical studies are required to further substantiate the role of sesamin in the prevention and/or treatment of COVID-19. |
| format | article |
| id | aus_d386c6f46f1f421da978ce92714dbfc1 |
| identifier_str_mv | Majdalawieh AF, Yousef SM, Abu-Yousef IA. Potential immunomodulatory role of sesamin in combating immune dysregulation associated with COVID-19. Asian Pac J Trop Biomed 2021; 11(10): 421-428. https://www.apjtb.org/text.asp?2021/11/10/421/326096 2221-1691 10.4103/2221-1691.326096 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/25042 |
| publishDate | 2021 |
| publisher.none.fl_str_mv | Medknow Publications |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Potential immunomodulatory role of sesamin in combating immune dysregulation associated with COVID-19Majdalawieh, AminYousef, Sarah M.Abu-Yousef, ImadSesaminSARS-CoV-2COVID-19ImmunomodulationAnti-inflammatoryCytokine stormTh1/Th2 balanceThe ongoing outbreak of novel coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused an unprecedented global health crisis. Development of a cure for this devastating disease is currently at full speed, with several vaccines against COVID-19 already authorized and administered. Currently, demand for these vaccines far exceeds supply. As such, boosting immunity represents a viable route to halt the rapid spread of SARS-CoV-2 and limit fatalities until vaccines become more readily and widely available. The use of phytochemicals appears to be a promising panacea. Sesamin, a lignan isolated from Sesamum indicum seeds, is known for its potent pharmacological properties, and is therefore hypothesized as a potential candidate in the therapeutic regimen against COVID-19. Herein, we highlight the confirmed therapeutic anti-inflammatory and immune-modulatory potential of sesamin against myriads of respiratory disorders, and tentatively suggest that sesamin may exert similar potent effects against COVID-19. Precisely, we speculate that sesamin may help alleviate COVID-19 via restoring Th1/Th2 balance and preventing inflammation and cytokine storm development. Additionally, we further support the promising role of sesamin against COVID-19 by underscoring the direct evidence, which suggests that sesamin may demonstrate promising inhibitory potential against three important SARS-CoV-2 targets, namely main protease, spike protein, and angiotensin-converting enzyme 2 receptor. Although preliminary, there is ample evidence to propose sesamin as a potential phytotherapeutic and prophylactic candidate against COVID-19. Further in vitro, in vivo, and preclinical studies are required to further substantiate the role of sesamin in the prevention and/or treatment of COVID-19.Medknow Publications2022-10-24T06:21:06Z2022-10-24T06:21:06Z2021Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfMajdalawieh AF, Yousef SM, Abu-Yousef IA. Potential immunomodulatory role of sesamin in combating immune dysregulation associated with COVID-19. Asian Pac J Trop Biomed 2021; 11(10): 421-428. https://www.apjtb.org/text.asp?2021/11/10/421/3260962221-1691http://hdl.handle.net/11073/2504210.4103/2221-1691.326096en_UShttps://www.apjtb.org/text.asp?2021/11/10/421/326096oai:repository.aus.edu:11073/250422024-08-22T12:00:26Z |
| spellingShingle | Potential immunomodulatory role of sesamin in combating immune dysregulation associated with COVID-19 Majdalawieh, Amin Sesamin SARS-CoV-2 COVID-19 Immunomodulation Anti-inflammatory Cytokine storm Th1/Th2 balance |
| status_str | publishedVersion |
| title | Potential immunomodulatory role of sesamin in combating immune dysregulation associated with COVID-19 |
| title_full | Potential immunomodulatory role of sesamin in combating immune dysregulation associated with COVID-19 |
| title_fullStr | Potential immunomodulatory role of sesamin in combating immune dysregulation associated with COVID-19 |
| title_full_unstemmed | Potential immunomodulatory role of sesamin in combating immune dysregulation associated with COVID-19 |
| title_short | Potential immunomodulatory role of sesamin in combating immune dysregulation associated with COVID-19 |
| title_sort | Potential immunomodulatory role of sesamin in combating immune dysregulation associated with COVID-19 |
| topic | Sesamin SARS-CoV-2 COVID-19 Immunomodulation Anti-inflammatory Cytokine storm Th1/Th2 balance |
| url | http://hdl.handle.net/11073/25042 |