Characterization of Contusive Spinal Cord Injury by Monitoring Motor-Evoked Potential
This study involves longitudinal neuro-electrophysiological analysis using motor-evoked potentials (MEP) and the Basso, Beattie, and Bresnahan behavioral examinations (BBB) to evaluate moderate mid-thoracic contusive spinal cord injury (SCI) in a rat model. Objectives/Background: The objective of th...
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2024
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| Online Access: | https://hdl.handle.net/11073/26276 |
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| _version_ | 1864513442439757824 |
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| author | ALL, Angelo H. |
| author2 | Wong, Ka-Leung Al-Nashash, Hasan A. |
| author2_role | author author |
| author_facet | ALL, Angelo H. Wong, Ka-Leung Al-Nashash, Hasan A. |
| author_role | author |
| dc.creator.none.fl_str_mv | ALL, Angelo H. Wong, Ka-Leung Al-Nashash, Hasan A. |
| dc.date.none.fl_str_mv | 2024-11-07 2025-08-21T09:53:24Z 2025-08-21T09:53:24Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | ALL, A. H., Wong, K.-L., & Al-Nashash, H. A. (2024). Characterization of Contusive Spinal Cord Injury by Monitoring Motor-Evoked Potential. Biomedicines, 12(11), 2548. https://doi.org/10.3390/biomedicines12112548 2227-9059 https://hdl.handle.net/11073/26276 10.3390/biomedicines12112548 |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | MDPI |
| dc.relation.none.fl_str_mv | https://doi.org/10.3390/biomedicines12112548 |
| dc.rights.none.fl_str_mv | Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
| dc.subject.none.fl_str_mv | Spinal cord injury Contusion Motor-evoked potential Descending motor pathways |
| dc.title.none.fl_str_mv | Characterization of Contusive Spinal Cord Injury by Monitoring Motor-Evoked Potential |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | This study involves longitudinal neuro-electrophysiological analysis using motor-evoked potentials (MEP) and the Basso, Beattie, and Bresnahan behavioral examinations (BBB) to evaluate moderate mid-thoracic contusive spinal cord injury (SCI) in a rat model. Objectives/Background: The objective of the study is to characterize the onset and progression of contusive SCI over an eight-week period using a clinically applicable tool in an in vivo model. The background highlights the importance of a reliable and reproducible injury model and assessment tools for SCI. Methods: The methods section describes the experimental setup, including randomly assigned rats in three groups: Sham, Control, and Injury (undergoing a moderate contusive SCI using the NYU-Impactor). MEP monitoring and BBB examinations are conducted at baseline and weekly for eight weeks post-injury. Results: The results indicate that the relative MEP power spectral decreased to 11% and 22% in the left and right hindlimbs, respectively, during the first week post-SCI. In the second week, a slight spontaneous recovery was observed, reaching 17% in the left and 31% in the right hindlimbs. Over the following four weeks post-SCI, continuing deterioration of MEP signal power was observed with no detectable recovery. Conclusions: SCI attenuates hindlimb MEP power spectral and reduces locomotion, though the changes in MEP and locomotion exhibit distinct temporal patterns. The MEP monitoring provides valuable insights into the functional integrity of motor pathways following SCI and offer a sensitive and reliable assessment. By implementing MEP monitoring, researchers can track the progression of SCI and evaluate the efficacy of therapeutic interventions quantitatively. |
| format | article |
| id | aus_d4ece81e505a9ea43f3f3b995237d7ae |
| identifier_str_mv | ALL, A. H., Wong, K.-L., & Al-Nashash, H. A. (2024). Characterization of Contusive Spinal Cord Injury by Monitoring Motor-Evoked Potential. Biomedicines, 12(11), 2548. https://doi.org/10.3390/biomedicines12112548 2227-9059 10.3390/biomedicines12112548 |
| language_invalid_str_mv | en |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/26276 |
| publishDate | 2024 |
| publisher.none.fl_str_mv | MDPI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
| spelling | Characterization of Contusive Spinal Cord Injury by Monitoring Motor-Evoked PotentialALL, Angelo H.Wong, Ka-LeungAl-Nashash, Hasan A.Spinal cord injuryContusionMotor-evoked potentialDescending motor pathwaysThis study involves longitudinal neuro-electrophysiological analysis using motor-evoked potentials (MEP) and the Basso, Beattie, and Bresnahan behavioral examinations (BBB) to evaluate moderate mid-thoracic contusive spinal cord injury (SCI) in a rat model. Objectives/Background: The objective of the study is to characterize the onset and progression of contusive SCI over an eight-week period using a clinically applicable tool in an in vivo model. The background highlights the importance of a reliable and reproducible injury model and assessment tools for SCI. Methods: The methods section describes the experimental setup, including randomly assigned rats in three groups: Sham, Control, and Injury (undergoing a moderate contusive SCI using the NYU-Impactor). MEP monitoring and BBB examinations are conducted at baseline and weekly for eight weeks post-injury. Results: The results indicate that the relative MEP power spectral decreased to 11% and 22% in the left and right hindlimbs, respectively, during the first week post-SCI. In the second week, a slight spontaneous recovery was observed, reaching 17% in the left and 31% in the right hindlimbs. Over the following four weeks post-SCI, continuing deterioration of MEP signal power was observed with no detectable recovery. Conclusions: SCI attenuates hindlimb MEP power spectral and reduces locomotion, though the changes in MEP and locomotion exhibit distinct temporal patterns. The MEP monitoring provides valuable insights into the functional integrity of motor pathways following SCI and offer a sensitive and reliable assessment. By implementing MEP monitoring, researchers can track the progression of SCI and evaluate the efficacy of therapeutic interventions quantitatively.Hong Kong Baptist UniversityGeneral Research Fund of Hong KongMDPI2025-08-21T09:53:24Z2025-08-21T09:53:24Z2024-11-07Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfALL, A. H., Wong, K.-L., & Al-Nashash, H. A. (2024). Characterization of Contusive Spinal Cord Injury by Monitoring Motor-Evoked Potential. Biomedicines, 12(11), 2548. https://doi.org/10.3390/biomedicines121125482227-9059https://hdl.handle.net/11073/2627610.3390/biomedicines12112548enhttps://doi.org/10.3390/biomedicines12112548Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/oai:repository.aus.edu:11073/262762025-08-21T15:33:39Z |
| spellingShingle | Characterization of Contusive Spinal Cord Injury by Monitoring Motor-Evoked Potential ALL, Angelo H. Spinal cord injury Contusion Motor-evoked potential Descending motor pathways |
| status_str | publishedVersion |
| title | Characterization of Contusive Spinal Cord Injury by Monitoring Motor-Evoked Potential |
| title_full | Characterization of Contusive Spinal Cord Injury by Monitoring Motor-Evoked Potential |
| title_fullStr | Characterization of Contusive Spinal Cord Injury by Monitoring Motor-Evoked Potential |
| title_full_unstemmed | Characterization of Contusive Spinal Cord Injury by Monitoring Motor-Evoked Potential |
| title_short | Characterization of Contusive Spinal Cord Injury by Monitoring Motor-Evoked Potential |
| title_sort | Characterization of Contusive Spinal Cord Injury by Monitoring Motor-Evoked Potential |
| topic | Spinal cord injury Contusion Motor-evoked potential Descending motor pathways |
| url | https://hdl.handle.net/11073/26276 |