Further investigation of the mechanism of Doxorubicin release from P105 micelles using kinetic models
The kinetics of the release of Doxorubicin from Pluronic P105 micelles during ultrasonication and its subsequent re-encapsulation upon cessation of insonation were investigated. Four mechanisms are proposed to explain the acoustically-triggered Doxorubicin (Dox) release and re-encapsulation from Plu...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , |
| التنسيق: | article |
| منشور في: |
2006
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/11073/21272 |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513442824585216 |
|---|---|
| author | Stevenson-Abouelnasr, Dana |
| author2 | Husseini, Ghaleb Pitt, William G. |
| author2_role | author author |
| author_facet | Stevenson-Abouelnasr, Dana Husseini, Ghaleb Pitt, William G. |
| author_role | author |
| dc.creator.none.fl_str_mv | Stevenson-Abouelnasr, Dana Husseini, Ghaleb Pitt, William G. |
| dc.date.none.fl_str_mv | 2006 2021-01-14T07:33:31Z 2021-01-14T07:33:31Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Dana Stevenson-Abouelnasr, Ghaleb A. Husseini, William G. Pitt, Further investigation of the mechanism of Doxorubicin release from P105 micelles using kinetic models, Colloids and Surfaces B: Biointerfaces, Volume 55, Issue 1, 2007, Pages 59-66, ISSN 0927-7765, https://doi.org/10.1016/j.colsurfb.2006.11.006. 0927-7765 http://hdl.handle.net/11073/21272 10.1016/j.colsurfb.2006.11.006 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.relation.none.fl_str_mv | https://doi.org/10.1016/j.colsurfb.2006.11.006 |
| dc.subject.none.fl_str_mv | Modeling Ultrasound Doxorubicin Kinetics Pluronic micelles |
| dc.title.none.fl_str_mv | Further investigation of the mechanism of Doxorubicin release from P105 micelles using kinetic models |
| dc.type.none.fl_str_mv | Peer-Reviewed Postprint info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | The kinetics of the release of Doxorubicin from Pluronic P105 micelles during ultrasonication and its subsequent re-encapsulation upon cessation of insonation were investigated. Four mechanisms are proposed to explain the acoustically-triggered Doxorubicin (Dox) release and re-encapsulation from Pluronic P105 micelles. The four mechanisms are: micelle destruction; destruction of cavitating nuclei; reassembly of micelles, and the reencapsulation of Dox. The first mechanism, the destruction of micelles during insonation, causes the release of Dox into solution. The micelles are destroyed because of cavitation events produced by collapsing nuclei, or bubbles in the insonated solution. The second mechanism, the slow destruction of cavitating nuclei, results in a slow partial recovery phase, when a small amount of Dox is re-encapsulated. The third and fourth mechanisms, the reassembly of micelles and the re-encapsulatin of Dox, are independent of ultrasound. These two mechanism are responsible for maintaining the drug release at a partial level, and for recovery after insonation ceases. A normal distribution was used to describe micellar size. Parameters for the model were determined based upon the best observed fit to experimental data. The resulting model provides a good approximation to experimental data for the release of Dox from Pluronic P105 micelles. |
| format | article |
| id | aus_d50e6d9a219221bf31ba6fb279e417f4 |
| identifier_str_mv | Dana Stevenson-Abouelnasr, Ghaleb A. Husseini, William G. Pitt, Further investigation of the mechanism of Doxorubicin release from P105 micelles using kinetic models, Colloids and Surfaces B: Biointerfaces, Volume 55, Issue 1, 2007, Pages 59-66, ISSN 0927-7765, https://doi.org/10.1016/j.colsurfb.2006.11.006. 0927-7765 10.1016/j.colsurfb.2006.11.006 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/21272 |
| publishDate | 2006 |
| publisher.none.fl_str_mv | Elsevier |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Further investigation of the mechanism of Doxorubicin release from P105 micelles using kinetic modelsStevenson-Abouelnasr, DanaHusseini, GhalebPitt, William G.ModelingUltrasoundDoxorubicinKineticsPluronic micellesThe kinetics of the release of Doxorubicin from Pluronic P105 micelles during ultrasonication and its subsequent re-encapsulation upon cessation of insonation were investigated. Four mechanisms are proposed to explain the acoustically-triggered Doxorubicin (Dox) release and re-encapsulation from Pluronic P105 micelles. The four mechanisms are: micelle destruction; destruction of cavitating nuclei; reassembly of micelles, and the reencapsulation of Dox. The first mechanism, the destruction of micelles during insonation, causes the release of Dox into solution. The micelles are destroyed because of cavitation events produced by collapsing nuclei, or bubbles in the insonated solution. The second mechanism, the slow destruction of cavitating nuclei, results in a slow partial recovery phase, when a small amount of Dox is re-encapsulated. The third and fourth mechanisms, the reassembly of micelles and the re-encapsulatin of Dox, are independent of ultrasound. These two mechanism are responsible for maintaining the drug release at a partial level, and for recovery after insonation ceases. A normal distribution was used to describe micellar size. Parameters for the model were determined based upon the best observed fit to experimental data. The resulting model provides a good approximation to experimental data for the release of Dox from Pluronic P105 micelles.Elsevier2021-01-14T07:33:31Z2021-01-14T07:33:31Z2006Peer-ReviewedPostprintinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfDana Stevenson-Abouelnasr, Ghaleb A. Husseini, William G. Pitt, Further investigation of the mechanism of Doxorubicin release from P105 micelles using kinetic models, Colloids and Surfaces B: Biointerfaces, Volume 55, Issue 1, 2007, Pages 59-66, ISSN 0927-7765, https://doi.org/10.1016/j.colsurfb.2006.11.006.0927-7765http://hdl.handle.net/11073/2127210.1016/j.colsurfb.2006.11.006en_UShttps://doi.org/10.1016/j.colsurfb.2006.11.006oai:repository.aus.edu:11073/212722024-08-22T12:05:30Z |
| spellingShingle | Further investigation of the mechanism of Doxorubicin release from P105 micelles using kinetic models Stevenson-Abouelnasr, Dana Modeling Ultrasound Doxorubicin Kinetics Pluronic micelles |
| status_str | publishedVersion |
| title | Further investigation of the mechanism of Doxorubicin release from P105 micelles using kinetic models |
| title_full | Further investigation of the mechanism of Doxorubicin release from P105 micelles using kinetic models |
| title_fullStr | Further investigation of the mechanism of Doxorubicin release from P105 micelles using kinetic models |
| title_full_unstemmed | Further investigation of the mechanism of Doxorubicin release from P105 micelles using kinetic models |
| title_short | Further investigation of the mechanism of Doxorubicin release from P105 micelles using kinetic models |
| title_sort | Further investigation of the mechanism of Doxorubicin release from P105 micelles using kinetic models |
| topic | Modeling Ultrasound Doxorubicin Kinetics Pluronic micelles |
| url | http://hdl.handle.net/11073/21272 |