Ultrasonically Controlled Albumin-conjugated Liposomes for Breast Cancer Therapy
Targeted liposomes have high potentials in the specific and effective delivery of their loaded therapeutic agents to the tumor site. Once at the tumor site, it is important that these liposomes are triggered to release their load in a controlled and effective manner. In this study, pegylated (stealt...
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| Other Authors: | , , |
| Format: | article |
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2019
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| Online Access: | http://hdl.handle.net/11073/16588 |
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| _version_ | 1864513435843166208 |
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| author | Awad, Nahid S. |
| author2 | Paul, Vinod Al-Sayah, Mohammad Husseini, Ghaleb |
| author2_role | author author author |
| author_facet | Awad, Nahid S. Paul, Vinod Al-Sayah, Mohammad Husseini, Ghaleb |
| author_role | author |
| dc.creator.none.fl_str_mv | Awad, Nahid S. Paul, Vinod Al-Sayah, Mohammad Husseini, Ghaleb |
| dc.date.none.fl_str_mv | 2019 2020-02-03T08:00:03Z 2020-02-03T08:00:03Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Nahid S. Awad, Vinod Paul, Mohammad H. Al-Sayah & Ghaleb A. Husseini (2019) Ultrasonically controlled albumin-conjugated liposomes for breast cancer therapy, Artificial Cells, Nanomedicine, and Biotechnology, 47:1, 705-714, DOI:10.1080/21691401.2019.1573175 2169-1401 http://hdl.handle.net/11073/16588 10.1080/21691401.2019.1573175 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | Taylor and Francis Online |
| dc.relation.none.fl_str_mv | https://doi.org/10.1080/21691401.2019.1573175 |
| dc.subject.none.fl_str_mv | Human serum albumin Liposomes Calcein Breast cancer Ultrasound |
| dc.title.none.fl_str_mv | Ultrasonically Controlled Albumin-conjugated Liposomes for Breast Cancer Therapy |
| dc.type.none.fl_str_mv | Peer-Reviewed Postprint info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Targeted liposomes have high potentials in the specific and effective delivery of their loaded therapeutic agents to the tumor site. Once at the tumor site, it is important that these liposomes are triggered to release their load in a controlled and effective manner. In this study, pegylated (stealth) liposomes conjugated to human serum albumin (HSA) were investigated for the delivery of a model drug (calcein) to breast cancer cells. The fluorescent results showed that calcein uptake by the two breast cancer cell lines (MDA-MB-231 and MCF-7) was significantly higher with the HSA-PEG liposomes compared to the non-targeted control liposomes. Furthermore, the exposure to low-frequency ultrasound (LFUS) resulted in a statistically significant uptake of calcein compared to the uptake without ultrasound. The described drug delivery (DD) system, which involves combining the targeted liposomal formulation with ultrasonic triggering techniques, promises a safe, effective and site-specific breast cancer therapy. |
| format | article |
| id | aus_d9480f1faf6167e3603b3fe348452248 |
| identifier_str_mv | Nahid S. Awad, Vinod Paul, Mohammad H. Al-Sayah & Ghaleb A. Husseini (2019) Ultrasonically controlled albumin-conjugated liposomes for breast cancer therapy, Artificial Cells, Nanomedicine, and Biotechnology, 47:1, 705-714, DOI:10.1080/21691401.2019.1573175 2169-1401 10.1080/21691401.2019.1573175 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/16588 |
| publishDate | 2019 |
| publisher.none.fl_str_mv | Taylor and Francis Online |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Ultrasonically Controlled Albumin-conjugated Liposomes for Breast Cancer TherapyAwad, Nahid S.Paul, VinodAl-Sayah, MohammadHusseini, GhalebHuman serum albuminLiposomesCalceinBreast cancerUltrasoundTargeted liposomes have high potentials in the specific and effective delivery of their loaded therapeutic agents to the tumor site. Once at the tumor site, it is important that these liposomes are triggered to release their load in a controlled and effective manner. In this study, pegylated (stealth) liposomes conjugated to human serum albumin (HSA) were investigated for the delivery of a model drug (calcein) to breast cancer cells. The fluorescent results showed that calcein uptake by the two breast cancer cell lines (MDA-MB-231 and MCF-7) was significantly higher with the HSA-PEG liposomes compared to the non-targeted control liposomes. Furthermore, the exposure to low-frequency ultrasound (LFUS) resulted in a statistically significant uptake of calcein compared to the uptake without ultrasound. The described drug delivery (DD) system, which involves combining the targeted liposomal formulation with ultrasonic triggering techniques, promises a safe, effective and site-specific breast cancer therapy.Taylor and Francis Online2020-02-03T08:00:03Z2020-02-03T08:00:03Z2019Peer-ReviewedPostprintinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfNahid S. Awad, Vinod Paul, Mohammad H. Al-Sayah & Ghaleb A. Husseini (2019) Ultrasonically controlled albumin-conjugated liposomes for breast cancer therapy, Artificial Cells, Nanomedicine, and Biotechnology, 47:1, 705-714, DOI:10.1080/21691401.2019.15731752169-1401http://hdl.handle.net/11073/1658810.1080/21691401.2019.1573175en_UShttps://doi.org/10.1080/21691401.2019.1573175oai:repository.aus.edu:11073/165882024-08-22T12:04:24Z |
| spellingShingle | Ultrasonically Controlled Albumin-conjugated Liposomes for Breast Cancer Therapy Awad, Nahid S. Human serum albumin Liposomes Calcein Breast cancer Ultrasound |
| status_str | publishedVersion |
| title | Ultrasonically Controlled Albumin-conjugated Liposomes for Breast Cancer Therapy |
| title_full | Ultrasonically Controlled Albumin-conjugated Liposomes for Breast Cancer Therapy |
| title_fullStr | Ultrasonically Controlled Albumin-conjugated Liposomes for Breast Cancer Therapy |
| title_full_unstemmed | Ultrasonically Controlled Albumin-conjugated Liposomes for Breast Cancer Therapy |
| title_short | Ultrasonically Controlled Albumin-conjugated Liposomes for Breast Cancer Therapy |
| title_sort | Ultrasonically Controlled Albumin-conjugated Liposomes for Breast Cancer Therapy |
| topic | Human serum albumin Liposomes Calcein Breast cancer Ultrasound |
| url | http://hdl.handle.net/11073/16588 |