Thermosensitive Polymers and Thermo-Responsive Liposomal Drug Delivery Systems
Temperature excursions within a biological milieu can be effectively used to induce drug release from thermosensitive drug-encapsulating nanoparticles. Oncological hyperthermia is of particular interest, as it is proven to synergistically act to arrest tumor growth when combined with optimally-desig...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , |
| التنسيق: | article |
| منشور في: |
2022
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/11073/21642 |
| الوسوم: |
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| _version_ | 1864513432325193728 |
|---|---|
| author | Abuwatfa, Waad Hussein |
| author2 | Awad, Nahid S. Pitt, William G. Husseini, Ghaleb |
| author2_role | author author author |
| author_facet | Abuwatfa, Waad Hussein Awad, Nahid S. Pitt, William G. Husseini, Ghaleb |
| author_role | author |
| dc.creator.none.fl_str_mv | Abuwatfa, Waad Hussein Awad, Nahid S. Pitt, William G. Husseini, Ghaleb |
| dc.date.none.fl_str_mv | 2022-02-28T07:03:32Z 2022-02-28T07:03:32Z 2022 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Abuwatfa, W.H.; Awad, N.S.; Pitt, W.G.; Husseini, G.A. Thermosensitive Polymers and Thermo-Responsive Liposomal Drug Delivery Systems. Polymers 2022, 14, 925. https://doi.org/10.3390/polym14050925 2073-4360 http://hdl.handle.net/11073/21642 10.3390/polym14050925 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | MDPI |
| dc.relation.none.fl_str_mv | https://doi.org/10.3390/polym14050925 |
| dc.subject.none.fl_str_mv | Hyperthermia Thermosensitivity Liposomes Critical solution temperature Lysolipids Polymers |
| dc.title.none.fl_str_mv | Thermosensitive Polymers and Thermo-Responsive Liposomal Drug Delivery Systems |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Temperature excursions within a biological milieu can be effectively used to induce drug release from thermosensitive drug-encapsulating nanoparticles. Oncological hyperthermia is of particular interest, as it is proven to synergistically act to arrest tumor growth when combined with optimally-designed smart drug delivery systems (DDSs). Thermoresponsive DDSs aid in making the drugs more bioavailable, enhance the therapeutic index and pharmacokinetic trends, and provide the spatial placement and temporal delivery of the drug into localized anatomical sites. This paper reviews the fundamentals of thermosensitive polymers, with a particular focus on thermoresponsive liposomal-based drug delivery systems. |
| format | article |
| id | aus_da09d1691ff980dcc134ffdc64b7b8fc |
| identifier_str_mv | Abuwatfa, W.H.; Awad, N.S.; Pitt, W.G.; Husseini, G.A. Thermosensitive Polymers and Thermo-Responsive Liposomal Drug Delivery Systems. Polymers 2022, 14, 925. https://doi.org/10.3390/polym14050925 2073-4360 10.3390/polym14050925 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/21642 |
| publishDate | 2022 |
| publisher.none.fl_str_mv | MDPI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Thermosensitive Polymers and Thermo-Responsive Liposomal Drug Delivery SystemsAbuwatfa, Waad HusseinAwad, Nahid S.Pitt, William G.Husseini, GhalebHyperthermiaThermosensitivityLiposomesCritical solution temperatureLysolipidsPolymersTemperature excursions within a biological milieu can be effectively used to induce drug release from thermosensitive drug-encapsulating nanoparticles. Oncological hyperthermia is of particular interest, as it is proven to synergistically act to arrest tumor growth when combined with optimally-designed smart drug delivery systems (DDSs). Thermoresponsive DDSs aid in making the drugs more bioavailable, enhance the therapeutic index and pharmacokinetic trends, and provide the spatial placement and temporal delivery of the drug into localized anatomical sites. This paper reviews the fundamentals of thermosensitive polymers, with a particular focus on thermoresponsive liposomal-based drug delivery systems.Dana Gas Endowed Chair for Chemical EngineeringAmerican University of SharjahSheikh Hamdan Award for Medical SciencesFriends of Cancer PatientMDPI2022-02-28T07:03:32Z2022-02-28T07:03:32Z2022Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfAbuwatfa, W.H.; Awad, N.S.; Pitt, W.G.; Husseini, G.A. Thermosensitive Polymers and Thermo-Responsive Liposomal Drug Delivery Systems. Polymers 2022, 14, 925. https://doi.org/10.3390/polym140509252073-4360http://hdl.handle.net/11073/2164210.3390/polym14050925en_UShttps://doi.org/10.3390/polym14050925oai:repository.aus.edu:11073/216422024-08-22T12:04:06Z |
| spellingShingle | Thermosensitive Polymers and Thermo-Responsive Liposomal Drug Delivery Systems Abuwatfa, Waad Hussein Hyperthermia Thermosensitivity Liposomes Critical solution temperature Lysolipids Polymers |
| status_str | publishedVersion |
| title | Thermosensitive Polymers and Thermo-Responsive Liposomal Drug Delivery Systems |
| title_full | Thermosensitive Polymers and Thermo-Responsive Liposomal Drug Delivery Systems |
| title_fullStr | Thermosensitive Polymers and Thermo-Responsive Liposomal Drug Delivery Systems |
| title_full_unstemmed | Thermosensitive Polymers and Thermo-Responsive Liposomal Drug Delivery Systems |
| title_short | Thermosensitive Polymers and Thermo-Responsive Liposomal Drug Delivery Systems |
| title_sort | Thermosensitive Polymers and Thermo-Responsive Liposomal Drug Delivery Systems |
| topic | Hyperthermia Thermosensitivity Liposomes Critical solution temperature Lysolipids Polymers |
| url | http://hdl.handle.net/11073/21642 |